Project Exodus

A design for a manned Mars mission, PROJECT EXODUS is presented. PROJECT EXODUS incorporates the design of a hypersonic waverider, cargo ship and NIMF (nuclear rocket using indigenous Martian fuel) shuttle lander to safely carry out a three to five month mission on the surface of Mars. The cargo ship transports return fuel, return engine, surface life support, NIMF shuttle, and the Mars base to low Mars orbit (LMO). The cargo ship is powered by a nuclear electric propulsion (NEP) system which allows the cargo ship to execute a spiral trajectory to Mars. The waverider transports ten astronauts to Mars and back. It is launched from the Space Station with propulsion provided by a chemical engine and a delta velocity of 9 km/sec. The waverider performs an aero-gravity assist maneuver through the atmosphere of Venus to obtain a deflection angle and increase in delta velocity. Once the waverider and cargo ship have docked the astronauts will detach the landing cargo capsules and nuclear electric power plant and remotely pilot them to the surface. They will then descend to the surface aboard the NIMF shuttle. A dome base will be quickly constructed on the surface and the astronauts will conduct an exploratory mission for three to five months. They will return to Earth and dock with the Space Station using the waverider

On Multiple Semantics for Declarative Database Repairs

We study the problem of database repairs through a rule-based framework that we refer to as Delta Rules. Delta Rules are highly expressive and allow specifying complex, cross-relations repair logic associated with Denial Constraints, Causal Rules, and allowing to capture Database Triggers of interest. We show that there are no one-size-fits-all semantics for repairs in this inclusive setting, and we consequently introduce multiple alternative semantics, presenting the case for using each of them. We then study the relationships between the semantics in terms of their output and the complexity of computation. Our results formally establish the tradeoff between the permissiveness of the semantics and its computational complexity. We demonstrate the usefulness of the framework in capturing multiple data repair scenarios for an Academic Search database and the TPC-H databases, showing how using different semantics affects the repair in terms of size and runtime, and examining the relationships between the repairs. We also compare our approach with SQL triggers and a state-of-the-art data repair system

The Lantern Vol. 62, No. 2, Summer 1995

• In the Season of Grief • Subtleties • Crazehaze • Blacksmith • I Feel Your Weight • L\u27Amour Manque • Sense of You • Greed • Gender (Rolled) • Soliloquy of a Punter • Nightmares • God is a Frisbee • Cleansing • Flat • Chemistry of Mind • Louderback • Ritual • Rebuilding Mother • Scott Lomba • The Acting Bug • Untitled • The Seek • Gluttony • Great South Bay • Archangel • Suburban Zeus • Vespers • At Change of A-Dress • The Hierarchy of Coolness • The Apology • I Know it is Evening There • Pridehttps://digitalcommons.ursinus.edu/lantern/1146/thumbnail.jp

Deletion of Genes Implicated in Protecting the Integrity of Male Germ Cells Has Differential Effects on the Incidence of DNA Breaks and Germ Cell Loss

Infertility affects approximately 20% of couples in Europe and in 50% of cases the problem lies with the male partner. The impact of damaged DNA originating in the male germ line on infertility is poorly understood but may increase miscarriage. Mouse models allow us to investigate how deficiencies in DNA repair/damage response pathways impact on formation and function of male germ cells. We have investigated mice with deletions of ERCC1 (excision repair cross-complementing gene 1), MSH2 (MutS homolog 2, involved in mismatch repair pathway), and p53 (tumour suppressor gene implicated in elimination of germ cells with DNA damage).We demonstrate for the first time that depletion of ERCC1 or p53 from germ cells results in an increased incidence of unrepaired DNA breaks in pachytene spermatocytes and increased numbers of caspase-3 positive (apoptotic) germ cells. Sertoli cell-only tubules were detected in testes from mice lacking expression of ERCC1 or MSH2 but not p53. The number of sperm recovered from epididymes was significantly reduced in mice lacking testicular ERCC1 and 40% of sperm contained DNA breaks whereas the numbers of sperm were not different to controls in adult Msh2 -/- or p53 -/- mice nor did they have significantly compromised DNA.These data have demonstrated that deletion of Ercc1, Msh2 and p53 can have differential but overlapping affects on germ cell function and sperm production. These findings increase our understanding of the ways in which gene mutations can have an impact on male fertility