Performance of the INGV National Seismic Network from 1997 to 2007

Seismic monitoring in Italy has strongly improved since the 1997 Umbria-Marche earthquake sequence. This has made the National Seismic Network (RSN) a powerful tool both to rapidly locate and quantify thousands of earthquakes occurring in Italy every year, and to study the seismic activity in detail, accumulating an impressive high quality data set that will be exploited in the coming years to understand earthquake processes and to investigate the deep structure. This paper summarizes and compares the basic features of the seismicity recorded in 2000 and 2006, before and after the implementation of the new RSN, showing that the number of well located earthquakes has more than doubled and that the completeness magnitude has dropped from ~2.3 to ~1.7. In addition, we concentrate on the evaluation of the current automatic location and magnitudes versus the revised ones, published routinely in the INGV bulletins. We show that the rapid estimates of locations and magnitudes are robust and reliable for most regions in Italy: more than 75% of the earthquakes are located in real time within 10km from the «true» locations, whereas the rapid magnitudes ML are within ±0.4 from the revised values in 90% of cases. The comparison between real-time and revised locations shows that there are a few regions in Italy where a further network improvement is still desirable. These include all the off-shore regions, Calabria, western Sicily, the Alpine and Po Plain region, and some small areas along the peninsula

PREAMI: Perindopril and remodelling in elderly with acute myocardial infarction: Study rationale and design

Angiotensin-converting enzyme (ACE) inhibitors reduce mortality, the development of remodeling, left ventricular (LV) dysfunction, and ischemic events, both when administered alone as long-term treatment in patients with impaired LV function and/or heart failure (HF) and as short-term treatment, early after acute myocardial infarction (AMI) and/or HF. The few data available on the use of ACE inhibitors in the elderly after AMI are conflicting. Nothing is known about the effects of ACE inhibitors in elderly postinfarction patients with preserved LV function: these patients have a remarkable medium- to long-term mortality and HF incidence after infarction. The aim of this study is to evaluate, in patients with AMI aged ≥65 years, the effects of Perindopril on the combined outcome of death, hospitalization for HF, and heart remodeling, considered to be a ≥8% increase in LV end-diastolic volume (LVEDV). Secondary objectives include the same factors listed in the primary end points hut considered separately. In addition, safety of the drug, ventricular remodeling, and adaptation are being evaluated. A total of 1100 patients with AMI (first episode or reinfarction), aged ≥65 years, and preserved or only moderately depressed LV (LV ejection fraction ≥40%), are to he enrolled and randomly assigned to treatment (8 mg for 12 months of Perindopril or placebo, in double-blind conditions). Clinical assessment is performed at fixed times, and periodic evaluations of (1) ventricular shape, dimensions, and function by quantitative 2-D echocardiography, and (2) heart rate variability and arrhythmias by ambulatory electrocardiographic monitoring are anticipated. The results and conclusions will be available by 2002 year