384 research outputs found
Immune cells and oxidative stress in the endotoxin tolerance mouse model
Sepsis is a systemic inflammatory response that can lead to tissue damage and death. In order to increase our understanding of sepsis, experimental models are needed that produce relevant immune and inflammatory responses during a septic event. We describe a lipopolysaccharide tolerance mouse model to characterize the cellular and molecular alterations of immune cells during sepsis. The model presents a typical lipopolysaccharide tolerance pattern in which tolerance is related to decreased production and secretion of cytokines after a subsequent exposure to a lethal dose of lipopolysaccharide. The initial lipopolysaccharide exposure also altered the expression patterns of cytokines and was followed by an 8- and a 1.5-fold increase in the T helper 1 and 2 cell subpopulations. Behavioral data indicate a decrease in spontaneous activity and an increase in body temperature following exposure to lipopolysaccharide. In contrast, tolerant animals maintained production of reactive oxygen species and nitric oxide when terminally challenged by cecal ligation and puncture (CLP). Survival study after CLP showed protection in tolerant compared to naive animals. Spleen mass increased in tolerant animals followed by increases of B lymphocytes and subpopulation Th1 cells. An increase in the number of stem cells was found in spleen and bone marrow. We also showed that administration of spleen or bone marrow cells from tolerant to naive animals transfers the acquired resistance status. In conclusion, lipopolysaccharide tolerance is a natural reprogramming of the immune system that increases the number of immune cells, particularly T helper 1 cells, and does not reduce oxidative stress.FAPESPCNP
Spinorial Field and Lyra Geometry
The Dirac field is studied in a Lyra space-time background by means of the
classical Schwinger Variational Principle. We obtain the equations of motion,
establish the conservation laws, and get a scale relation relating the
energy-momentum and spin tensors. Such scale relation is an intrinsic property
for matter fields in Lyra background.Comment: 10 pages. Some misprints correcte
Distribuição de potássio, magnésio e outros metais em minerais de sedimentos do grupo barreiras no município de Aracruz, estado do Espírito Santo
Contribution of humic substances from different composts to the synthesis of humin in a tropical soil
Seleção de famílias para aparência dos tubérculos e tolerância a temperaturas elevadas em batata
Growth of seedlings of pigeon pea (Cajanus cajan (l.) millsp), wand riverhemp (Sesbania virgata (cav.) pers.), and lead tree (Leucaena leucocephala (lam.) de wit) in an arsenic-contaminated soil
Controle das parasitoses gastrintestinais em ovinos e caprinos na região semiárida do Nordeste do Brasil
Uso de técnicas estatísticas para modelar a resistência à flexão de corpos cerâmicos contendo resíduo de granito
- …