27 research outputs found
Absorption and quasinormal modes of classical fields propagating on 3D and 4D de Sitter spacetime
We extensively study the exact solutions of the massless Dirac equation in 3D
de Sitter spacetime that we published recently. Using the Newman-Penrose
formalism, we find exact solutions of the equations of motion for the massless
classical fields of spin s=1/2,1,2 and to the massive Dirac equation in 4D de
Sitter metric. Employing these solutions, we analyze the absorption by the
cosmological horizon and de Sitter quasinormal modes. We also comment on the
results given by other authors.Comment: 31 page
Avaliação dos parâmetros cardiorrespiratórios, hemogasométricos e da concentração plasmática de cortisol em bovinos submetidos à imobilização eletromagnética
Transport kinetics of four- and six-coordinate platinum compounds in the multicell layer tumour model
Four-coordinate (Pt(II)) platinum-based anticancer drugs are widely used in primary or palliative chemotherapy and produce considerable efficacy in certain clinical applications, for example testicular cancer. However, in many cancers the Pt(II) drugs are beset by poor efficacy mainly due to suboptimal pharmacokinetic properties. Consequently, the six-coordinate (Pt(IV)) class of Pt drugs were developed to improve platinum efficacy by (i) increasing stability, (ii) reducing reactivity, (iii) increasing lipophilicity, and (iv) nuclear targeting. However, comparatively little information is available on the pharmacokinetic properties of these compounds within solid tumour tissue. In the present study, the distribution and fluxes of [14C]-labelled [PtCl2(en)] (where en stands for ethane-1,2-diamine) and cis,trans-[PtCl2(OH)2(en)] drugs were determined in the multicell layer (MCL) tumour model comprising colon cancer cells. Flux data were analysed by mathematical modelling of drug diffusion and cellular uptake in the transport system. The flux of the Pt(IV) compound through the MCL was not significantly different to that of the Pt(II) drug nor were the diffusion coefficient or tissue uptake; the latter confirmed with elemental imaging analysis by synchrotron radiation induced X-ray emission. However, the flux of the Pt(IV) through the MCL was increased by hydrostatic pressure, thereby demonstrating the potential to target cancer cells further away from the vessels with six-coordinate platinum drugs.<br/