RF safety assessment in ultra-high field MRI: New approaches to reduce local SAR estimation errors

The radiofrequency (RF) safety constraints remain a major factor limiting the quality and speed of ultra-high field magnetic resonance imaging (UHF-MRI) and the use of parallel transmission (pTx) technology. Since the local Specific Absorption Rate (SAR) cannot be measured during an MRI examination, it is usually evaluated by off-line electromagnetic simulations using generic body models. To avoid potential local SAR underestimation due to deviations between actual and simulated MR examination scenario (such as differences in patient anatomy and in positioning, loading and coupling of the RF transmit array elements), the current most common practices are to include a safety factor around 2 and/or consider the worst-case peak local SAR value. Thus, the MRI exam can take more than double the actually required time for the same image quality. Software tools to perform on-line simulations using patient-specific body models are being developed but they still require a rather long on-line preparation time (to build the model, perform the simulations, and process the results). In this thesis, several important contributions and new concepts aimed at improving the performance of UHF-MRI systems are presented, with the most relevant being: the trigonometric maximization method to determine the actual worst-case local SAR without any overestimation in a few milliseconds (Chapter 2); the introduction of the 99.9% safe peak local SAR assessment concept to be used as an alternative to the worst-case local SAR (emerged from the extensive inter-subject local SAR variability analysis in Chapter 3 and underlying the conditional safety margin presented in Chapter 5); the first Artificial Intelligence (AI) approach for local SAR assessment (Chapter 4); and a Bayesian framework to more effectively address the inevitable residual error in the local SAR estimate and to identify potentially dangerous situations (Chapter 6). The use of these approaches reduced the mean local SAR overestimation error from over 100% to approximately 40%

Neues zum Pariser Albertismus des frühen 15. Jahrhunderts: der magister Lambertus de Monte und die Handschrift Brussel, Koniklijke Bibliotheek, Ms 760

Past and recent historiography on the fifteenth-century Wegestreit described early Parisian Albertism as an intellectual trend internal to the Arts Faculty and almost exclusively identified with the figure of Johannes de Nova Domo. Although historical documents hinted at the existence of a more established school, no further evidence could be provided. In this contribution we focus on the manuscript Brussel, Koninklijke Bibliotheek van België, ms. 760, which contains a commentary to the Sentences given at Paris by Lambertus de Monte, albertista magnus, around 1423. This previously unnoticed source turns out to be the first important witness of the presence of Albertism in the Faculty of Theology at Paris, and testifies to a significant reception and development of the ideas of Johannes de Nova Domo. Moreover, the manuscript evinces an interesting constellation of marginalia, some of which bear traces of unknown works of the Albertist Heymericus de Campo. The article aims to present the source from a textual and material perspective, insofar as it investigates also some peculiar aspects of the history of the manuscript. The codex came from the Augustinian Canons’ Convent of Korsendonk, where it was partially copied, as we discovered, by the erudite Johannes de Meehrout