Segmentation errors in scans of lower image quality and corresponding corrected segmentation after applying the semi-automated approach.

<p>(A) The algorithm mistakenly identified the OPL/ONL interface. (B) Corrected segmentation corresponding (A) after applying the semi-automated approach. (C) The algorithm mistakenly identified the RNFL/GCL boundary. (D) Corrected segmentation corresponding (C) after applying the semi-automated approach.</p

Comparison of the thickness measurements for eight intra-retinal layers and total retina between UHR-OCT and RTVue100 devices.

<p>P value: tested by paired-t test.</p

Tumor-Associated Neutrophils as a New Prognostic Factor in Cancer: A Systematic Review and Meta-Analysis

<div><p>Purpose</p><p>Tumor-associated neutrophils (TAN) have been reported in a variety of malignancies. We conducted an up-to-date meta-analysis to evaluate the prognostic role of TAN in cancer.</p><p>Method</p><p>Pubmed, Embase and web of science databases were searched for studies published up to April 2013. Pooled hazard ratios (HRs) and their corresponding 95% confidence intervals (CIs) were calculated. The impact of neutrophils localization and primary antibody were also assessed.</p><p>Results</p><p>A total of 3946 patients with various solid tumors from 20 studies were included. High density of intratumoral neutrophils were independently associated with unfavorable survival; the pooled HRs were 1.68 (95%CI: 1.36–2.07, I² = 55.8%, <i>p</i><0.001) for recurrence-free survival (RFS)/disease-free survival (DFS), 3.36 (95%CI: 2.08–5.42, I² = 0%, <i>p</i><0.001) for cancer-specific survival (CSS) and 1.66 (95%CI: 1.37–2.01, I² = 70.5%, <i>p</i><0.001) for overall survival (OS). Peritumoral and stromal neutrophils were not statistically significantly associated with survival. When grouped by primary antibody, the pooled HRs were 1.80 (95%CI: 1.47–2.22, I² = 67.7%, <i>p</i><0.001) for CD66b, and 1.44 (95%CI: 0.90–2.30, I² = 45.9%, <i>p</i> = 0.125) for CD15, suggesting that CD66b positive TAN might have a better prognostic value than CD15.</p><p>Conclusion</p><p>High levels of intratumoral neutrophils are associated with unfavorable recurrence-free, cancer-specific and overall survival.</p></div

Follow diagram of the meta-analysis.

<p>Follow diagram of the meta-analysis.</p

profiles of eight intra-retinal layers determined from the UHR-OCT and RTVue100 images in the horizontal meridian.

<p>Thickness profiles of eight intra-retinal layers along the horizontal meridian were averaged for 20 normal healthy eyes. Error bars represent standard deviation.</p

Characteristics of included studies.

<p>Abbreviations: Gastric: gastric carcinoma; RCC: renal cell carcinoma; HNC: head and neck carcinoma; HCC: hepatocellular carcinoma; ICC: intrahepatic cholangiocarcinoma; NSCLC: non-small-cell lung cancer; CRC: colorectal carcinomas; CC: cervical cancer; PDC: pancreatic ductal carcinoma; HE: hematoxylin-eosin staining; OS: overall survival; CSS: cancer-specific survival; RFS: recurrence-free survival; DFS: disease-free survival; NM: not mentioned; a: OS; b: CSS; c: RFS; d: DFS; m: months; y: years; DE: data extrapolated; SR: systematic review <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0098259#pone.0098259-Donskov3" target="_blank">[36]</a>.</p

Repeatability and reproducibility of thickness measurements for eight intra-retinal layers measured by the RTVue100.

<p>T1: mean thickness for the first measurement by examiner 1; T2: mean thickness for the second measurement by examiner 1; T3: mean thickness for the first measurement by examiner 2; ICCa: intraclass correlation coefficients of repeatability; ICCb: intraclass correlation coefficients of reproducibility; CORa: coefficients of repeatability; CORb: coefficients of reproducibility; n = 20 eyes.</p

Bland-Altman plots of thickness measurements determined with the automated segmentation algorithm on UHR-OCT and RTVue100 images.

<p>Only the images along the horizontal meridian were analyzed. The horizontal full lines represent the mean of thickness differences, and the horizontal dashed lines represent the mean differences ±1.96 standard deviation.</p

Sensitivity analysis of subgroups.

<p>(A) Sensitivity analysis of studies evaluated intratumoral neutrophils expression on OS. (B) Sensitivity analysis of studies evaluated intratumoral neutrophils expression on RFS/DFS.</p

Configuration of the two OCT instruments.

<p>Configuration of the two OCT instruments.</p