Hypothalamus–Muscle Parallel Induction of Metabolic Pathways Following Physical Exercise

The modern lifestyle requires less physical activity and skills during our daily routine, leading to multiple pathologies related to physical disabilities and energy accessibility. Thus, exploring the mechanisms underlying the metabolic regulation of exercise is crucial. Here, we characterized the effect of forced and voluntary endurance exercises on three key metabolic signaling pathways, sirtuins, AMPK, and mTOR, across several metabolic tissues in mice: brain, muscles, and liver. Both voluntary and forced exercises induced AMPK with higher intensity in the first. The comparison between those metabolic tissues revealed that the hypothalamus and the hippocampus, two brain parts, showed different metabolic signaling activities. Strikingly, despite the major differences in the physiology of muscles and hypothalamic tissues, the hypothalamus replicates the metabolic response of the muscle in response to physical exercise. Specifically, muscles and hypothalamic tissues showed an increase and a decrease in AMPK and mTOR signaling, respectively. Overall, this study reveals new insight into the relation between the hypothalamus and muscles, which enhances the coordination within the muscle–brain axis and potentially improves the systemic response to physical activity performance and delaying health inactivity disorders

Situated learning: The feasibility of an experimental learning of information technology for academic nursing students

As part of the Bachelor’s degree of nursing education, nursing students are exposed to the increasingly complex world of Information Technology. Aim: To evaluate the feasibility of a situated learning approach for Information Technology course by assessing students’ perceptions at the end of the course. Methods: Course participants completed a pre and post-course survey describing their knowledge and perceptions of the course. Results and discussion: Results demonstrated increased knowledge and satisfaction with this new learning strategy, which was also apparent in their good final course grades. Students had considerably more knowledge after the course (comparing to pre course survey), with a positive correlation between students’ perception of the usefulness of the course and their knowledge after completion of the course. Therefore, enhancing learning using a simulated learning curriculum may allow students to be more aware of the challenges that nurses face in actual practice, and may provide a more contextualized understanding of the issues relating to Information Technology