SIPS - Screening-Instrument für prämenstruelle Symptome*: Die deutsche Version des Premenstrual Symptoms Screening Tool zur Erfassung klinisch relevanter Beschwerden

Zusammenfassung: Hintergrund: Prämenstruelle dysphorische Störungen (PMDS) und schwere prämenstruelle Syndrome (PMS) treten häufig auf, bleiben jedoch oft unerkannt und unbehandelt. Begünstigt wird dies durch das Fehlen eines entsprechenden deutschsprachigen Screening-Instruments. Ziel dieser Studie war es, das englischsprachige Premenstrual Symptoms Screening Tool (PSST) ins Deutsche zu übertragen und seine Anwendung zu prüfen. Material und Methoden: Die deutschsprachige Version des PSST wurde als "Screening-Instrument für prämenstruelle Symptome" (SIPS) erstellt und ihre Güte an 47 Frauen mit und ohne PMDS/schwerem PMS internetbasiert mittels täglichen Symptomeinschätzungen bestimmt. Ergebnisse: Die Retest-Reliabilität des SIPS betrug r=0,69, das Cronbachsα 0,924. Als Validitätsmaß des SIPS zeigten sich signifikante Unterschiede zwischen Frauen mit und ohne PMDS/schwerem PMS, bestimmt durch das SIPS, bezüglich prospektiv erfasster prämenstrueller Symptomatik (F[2,44]=4,52, p<0,001) und Symptomveränderung (F[2,44]=25,23, p<0,001). Schlussfolgerung: Das SIPS ist reliabel und valide und kann helfen, Frauen mit behandlungsbedürftigen prämenstruellen Beschwerden zu identifiziere

SIPS - Screening-Instrument für prämenstruelle Symptome : Die deutsche Version des Premenstrual Symptoms Screening Tool zur Erfassung klinisch relevanter Beschwerden

Premenstrual Dysphoric Disorder (PMDD) and severe Premenstrual Syndrome (PMS) are common, yet often remain unrecognized and not adequately treated. One reason for this is the lack of a valid German screening instrument. The aim of the present study was to create a German version of the English "premenstrual symptoms screening tool (PSST)" and to verify its applicability. The German version of the PSST was created as "Screening- Instrument für Prämenstruelle Symptome (SIPS)" and its reliability and validity estimated based on data from 47 women with and without PMDD/severe PMS, using internet-based daily symptom-ratings. The retest-reliability of the SIPS was r=0.69, Cronbach`s Alpha was 0.924. As indicator of the convergent validity of the SIPS, there were significant differences between women with and without PMDD/severe PMS as identified by the SIPS, with regard to prospectively assessed premenstrual symptomatology (F(2,44)=4.52, p>0.001) and symptom change (F(2,44)=25.23, p>0.001). The SIPS is reliable and valid and may help improving the identification of women who require treatment for their premenstrual symptoms

Association of different restriction levels with COVID-19-related distress and mental health in somatic inpatients: a secondary analysis of swiss general hospital data

Background: The coronavirus disease 2019 (COVID-19) pandemic and related countermeasures hinder health care access and affect mental wellbeing of non-COVID-19 patients. There is lack of evidence on distress and mental health of patients hospitalized due to other reasons than COVID-19-a vulnerable population group in two ways: First, given their risk for physical diseases, they are at increased risk for severe courses and death related to COVID-19. Second, they may struggle particularly with COVID-19 restrictions due to their dependence on social support. Therefore, we investigated the association of intensity of COVID-19 restrictions with levels of COVID-19-related distress, mental health (depression, anxiety, somatic symptom disorder, and mental quality of life), and perceived social support among Swiss general hospital non-COVID-19 inpatients. Methods: We analyzed distress of 873 hospital inpatients not admitted for COVID-19, recruited from internal medicine, gynecology, rheumatology, rehabilitation, acute geriatrics, and geriatric rehabilitation wards of three hospitals. We assessed distress due to the COVID-19 pandemic, and four indicators of mental health: depressive and anxiety symptom severity, psychological distress associated with somatic symptoms, and the mental component of health-related quality of life; additionally, we assessed social support. The data collection period was divided into modest (June 9 to October 18, 2020) and strong (October 19, 2020, to April 17, 2021) COVID-19 restrictions, based on the Oxford Stringency Index for Switzerland. Results: An additional 13% (95%-Confidence Interval 4-21%) and 9% (1-16%) of hospital inpatients reported distress related to leisure time and loneliness, respectively, during strong COVID-19 restrictions compared to times of modest restrictions. There was no evidence for changes in mental health or social support. Conclusions: Focusing on the vulnerable population of general hospital inpatients not admitted for COVID-19, our results suggest that tightening of COVID-19 restrictions in October 2020 was associated with increased COVID-19-related distress regarding leisure time and loneliness, with no evidence for a related decrease in mental health. If this association was causal, safe measures to increase social interaction (e.g., virtual encounters and outdoor activities) are highly warranted. Trial registration: www.ClinicalTrials.gov, identifier: NCT04269005

Remote surface damage detection on rotor blades of operating wind turbines by means of infrared thermography

Wind turbines are constantly exposed to wind gusts, dirt particles and precipitation. Depending on the site, surface defects on rotor blades emerge from the first day of operation on. While erosion increases quickly with time, even small surface defects can affect the performance of the wind turbine. Consequently, there is demand for an easily applicable remote monitoring method for rotor blades that is capable of detecting surface defects at an early stage. In this work it is investigated if infrared thermography (IRT) can meet these requirements by visualizing differences in the thermal transport and the corresponding surface temperature of the wall-bounded flow.Firstly, a validation of the IRT method compared to stereoscopic particle image velocimetry measurements is performed comparing both types of experimental results for the boundary layer of a flat plate. Then, the main characteristics of the flow in the wake of generic surface defects on different types of lifting surfaces are studied both experimentally and numerically: temperature gradients behind protruding surface defects on a flat plate and a DU 91-W2-250 profile are studied by means of IRT. The same is done with the wall shear stress from Reynolds-averaged Navier–Stokes simulations of a wind turbine blade. It is consistently observed, both in the experiments and the simulations, that turbulent wedges are formed on the flow downstream of generic surface defects. These wedges provide valuable information about the kind of defects that generate them. At last, experimental and numerical performance measures are taken into account for evaluating the aerodynamic impact of surface defects on rotor blades. We conclude that the IRT method is a suitable remote monitoring technique for detecting surface defects on wind turbines at an early stage.</p

COVID-19-related consultation-liaison (CL) mental health services in general hospitals: A perspective from Europe and beyond

Objective: The COVID-19 pandemic posed new challenges for integrated health care worldwide. Our study aimed to describe newly implemented structures and procedures of psychosocial consultation and liaison (CL) services in Europe and beyond, and to highlight emerging needs for co-operation. Methods: Cross-sectional online survey from June to October 2021, using a self-developed 25-item questionnaire in four language versions (English, French, Italian, German). Dissemination was via national professional societies, working groups, and heads of CL services. Results: Of the participating 259 CL services from Europe, Iran, and parts of Canada, 222 reported COVID-19 related psychosocial care (COVID-psyCare) in their hospital. Among these, 86.5% indicated that specific COVID-psyCare co-operation structures had been established. 50.8% provided specific COVID-psyCare for patients, 38.2% for relatives, and 77.0% for staff. Over half of the time resources were invested for patients. About a quarter of the time was used for staff, and these interventions, typically associated with the liaison function of CL services, were reported as most useful. Concerning emerging needs, 58.1% of the CL services providing COVID-psyCare expressed wishes for mutual information exchange and support, and 64.0% suggested specific changes or improvements that they considered essential for the future. Conclusion: Over 80% of participating CL services established specific structures to provide COVID-psyCare for patients, their relatives, or staff. Mostly, resources were committed to patient care and specific interventions were largely implemented for staff support. Future development of COVID-psyCare warrants intensified intra- and inter-institutional exchange and co-operation

Determinants of workload-related clinician stress levels in general hospital consultation liaison psychiatry services during the COVID-19 pandemic in England and Ireland. Short report

OBJECTIVE: To explore workload-related stress levels experienced by consultation liaison psychiatry (CLP) staff in England and Ireland, and factors relevant to such a burden, during the COVID-19 pandemic. METHODS: Data were obtained for England and Ireland from a European survey among CLP services in general hospitals spread via CLP networks (11th June - 3rd October 2021). The heads of respective CLP services in general hospitals responded on behalf of each service, on 100 CLP hospital staff in total. DEPENDENT VARIABLE: workload-related stress levels in CLP services due to COVID-19 (0-10 point scale). INDEPENDENT VARIABLES: hospital size, CLP service size, degree of hospital involvement in COVID-19-related care, and the number of support options available to hospital staff. Spearman's rho correlation analyses were performed. RESULTS: There was a significant association between the hospital's involvement in COVID-19-related care and workload-related stress levels as reported by CLP staff: r(22) = 0.41, p = 0.045, R2 = 0.17. There were no significant associations between workload-related stress levels and other variables including staff support (p = 0.74). CONCLUSION: Our findings suggest that perceived workload-related stress levels of CLP staff during the COVID-19 pandemic can be an indicator of COVID-19 involvement of the hospitals. Staff support seemed not to alleviate work stress in the context of the pandemic. Healthcare policies should improve working conditions for CLP hospital staff that play an essential role from a population health perspective. Rigorous measures may be needed to ensure mental healthcare provision remains tenable and sustainable in the long term

Decreased startle modulation during anticipation in the postpartum period in comparison to late pregnancy

Knowledge about healthy women’s psychophysiological adaptations during the large neuroendocrine changes of pregnancy and childbirth is essential in order to understand why these events have the potential to disrupt mental health in vulnerable individuals. This study aimed to compare startle response modulation, an objective psychophysiological measure demonstrated to be influenced by anxiety and depression, longitudinally across late pregnancy and the postpartum period. The acoustic startle response modulation was assessed during anticipation of affective images and during image viewing in 31 healthy women during gestational weeks 36–39 and again at 4 to 6 weeks postpartum. No startle modulation by affective images was observed at either time point. Significant modulation during anticipation stimuli was found at pregnancy assessment but was reduced in the postpartum period. The women rated the unpleasant images more negative and more arousing and the pleasant images more positive at the postpartum assessment. Self-reported anxiety and depressive symptoms did not change between assessments. The observed postpartum decrease in modulation of startle by anticipation suggests a relatively deactivated defense system in the postpartum period

The Oxytocin Receptor (OXTR) Contributes to Prosocial Fund Allocations in the Dictator Game and the Social Value Orientations Task

Background: Economic games observe social decision making in the laboratory that involves real money payoffs. Previously we have shown that allocation of funds in the Dictator Game (DG), a paradigm that illustrates costly altruistic behavior, is partially determined by promoter-region repeat region variants in the arginine vasopressin 1a receptor gene (AVPR1a). In the current investigation, the gene encoding the related oxytocin receptor (OXTR) was tested for association with the DG and a related paradigm, the Social Values Orientation (SVO) task. Methodology/Principal Findings: Association (101 male and 102 female students) using a robust-family based test between 15 single tagging SNPs (htSNPs) across the OXTR was demonstrated with both the DG and SVO. Three htSNPs across the gene region showed significant association with both of the two games. The most significant association was observed with rs1042778 (p = 0.001). Haplotype analysis also showed significant associations for both DG and SVO. Following permutation test adjustment, significance was observed for 2–5 locus haplotypes (p,0.05). A second sample of 98 female subjects was subsequently and independently recruited to play the dictator game and was genotyped for the three significant SNPs found in the first sample. The rs1042778 SNP was shown to be significant for the second sample as well (p = 0.004, Fisher’s exact test). Conclusions: The demonstration that genetic polymorphisms for the OXTR are associated with human prosocial decisio