Study on Social Network for College Students\u27 Job Hunting

SNSs recruitment has caused the change of the traditional recruitment mode due to its advantages such as broad audience, quick information transmission, low recruitment cost and good interpersonal interaction. Through questionnaire survey, the paper implements on a study on the situation that the college students use social networks to find jobs. It is found that social network platforms are popular with college students, but it is not widely used in social job hunting platforms. What is more, the job hunting effect is not obvious. Meanwhile, the user information is prone to leakage, and the job hunting information provided is in poor quality. The paper proposes that the social network job hunting platforms should take measures to perfect the service content, strengthen the technical level and improve the information security for the college students. Additionally, the college students should also make reasonable choices and correctly utilize the social recruitment platform to protect the personal information security and improve the job hunting efficiency

Immunoproteomic analysis of outer membrane proteins and extracellular proteins of Actinobacillus pleuropneumoniae JL03 serotype 3

<p>Abstract</p> <p>Background</p> <p><it>Actinobacillus pleuropneumoniae </it>is the causative agent of porcine contagious pleuropneumonia, a highly contagious respiratory infection in pigs, and all the 15 serotypes are able to cause disease. Current vaccines including subunit vaccines could not provide satisfactory protection against <it>A. pleuropneumoniae</it>. In this study, the immunoproteomic approach was applied to the analysis of extracellular and outer membrane proteins of <it>A. pleuropneumoniae </it>JL03 serotype 3 for the identification of novel immunogenic proteins for <it>A. pleuropneumoniae</it>.</p> <p>Results</p> <p>A total of 30 immunogenic proteins were identified from outer membrane and extracellular proteins of JL03 serotype 3, of which 6 were known antigens and 24 were novel immunogenic proteins for <it>A. pleuropneumoniae</it>.</p> <p>Conclusion</p> <p>These data provide information about novel immunogenic proteins for <it>A. pleuropneumoniae </it>serotype 3, and are expected to aid in development of novel vaccines against <it>A. pleuropneumoniae</it>.</p

Effect of Water Distribution during Pre-drying on the Microstructure and Texture Properties of Peach Crisps Produced by Hot Air-Vacuum Freeze Drying

In this study, experiments were conducted to investigate the effect of moisture distribution during pre-drying on the microstructure and textural quality of hot air-vacuum freeze dried peach slices. The moisture distribution during the hot air pre-drying process at different temperatures (40, 60 and 80 ℃) and the product temperature during heating were monitored. Three levels of dry-basis moisture content (7, 6 and 5 g/g) were selected as moisture conversion points for each temperature. The color, shrinkage rate, microstructure, pore distribution, textural properties and hygroscopicity of peach crisps were measured. The results showed that drying temperature had a great impact on the moisture distribution during the pre-drying process, but the overall trends of moisture mobility were consistent among the different drying temperatures. The lower the moisture content of the pre-dried sample, the closer the color of the final dried sample to that of the fresh sample. The color of the sample dried at 40 ℃ with a moisture conversion point of 5 g/g was the closest to that of the fresh sample. Drying time had a greater effect on the shrinkage rate than temperature. It took longer to dry peach slices to the same moisture conversion point at 40 ℃ than 60 and 80 ℃. The sample shrank distinctly during both pre-drying and combined drying. There was a significant difference in the pore structure between the freeze-dried and combined dried samples. The sample with a moisture conversion point of 5 g/g had the most heterogeneous pore structure. The average hardness value of the hot air-vacuum freeze dried sample increased by 52.11% compared with that of the freeze-dried sample. The lower the moisture content of the pre-dried sample, the higher the hardness value of the hot air-vacuum freeze dried sample. This study showed that hot air pre-drying can effectively control the crunchiness and hardness of peach crisps. The decrease in the hygroscopicity of the hot air-vacuum freeze dried sample compared with the vacuum freeze dried one may be related to the structure changes during the pre-drying process. In summary, hot air-vacuum freeze drying is conducive to improving the texture quality and storage stability of peach crisps than vacuum freeze drying

The Special Neuraminidase Stalk-Motif Responsible for Increased Virulence and Pathogenesis of H5N1 Influenza A Virus

The variation of highly pathogenic avian influenza H5N1 virus results in gradually increased virulence in poultry, and human cases continue to accumulate. The neuraminidase (NA) stalk region of influenza virus varies considerably and may associate with its virulence. The NA stalk region of all N1 subtype influenza A viruses can be divided into six different stalk-motifs, H5N1/2004-like (NA-wt), WSN-like, H5N1/97-like, PR/8-like, H7N1/99-like and H5N1/96-like. The NA-wt is a special NA stalk-motif which was first observed in H5N1 influenza virus in 2000, with a 20-amino acid deletion in the 49th to 68th positions of the stalk region. Here we show that there is a gradual increase of the special NA stalk-motif in H5N1 isolates from 2000 to 2007, and notably, the special stalk-motif is observed in all 173 H5N1 human isolates from 2004 to 2007. The recombinant H5N1 virus with the special stalk-motif possesses the highest virulence and pathogenicity in chicken and mice, while the recombinant viruses with the other stalk-motifs display attenuated phenotype. This indicates that the special stalk-motif has contributed to the high virulence and pathogenicity of H5N1 isolates since 2000. The gradually increasing emergence of the special NA stalk-motif in H5N1 isolates, especially in human isolates, deserves attention by all

Unlocking high-performance organic cathodes: tailoring active group densities in covalent frameworks for aqueous zinc ion batteries

Aqueous zinc ion batteries (AZIBs) are a promising energy storage technology due to their cost-effectiveness and safety. Organic materials with sustainable and designable structures are of great interest as AZIBs cathodes. However, small molecules in organic cathode materials face dissolution problems and suboptimal cycle life, whereas large molecules suffer from a low theoretical capacity due to their inert carbon skeletons. Here, we designed two covalent organic framework (COF) materials (benzoquinoxaline benzoquinone-based COF (BB-COF) and triquinoxalinylene benzoquinone-based COF (TB-COF)) with the same structure and number of energy storage groups to investigate the correlation between the densities of active sites and electrochemical performance. We conclude that the electrochemical behavior of organic conjugate-based energy storage materials lacks a linear correlation with active site quantity. Adjusting active site densities is crucial for material advancement. BB-COF and TB-COF with dual active sites (C=O and C=N) exhibit distinct characteristics. TB-COF, which has dense active groups, shows a high initial capacity (222 mAh g−1). Conversely, BB-COF, which features a large conjugated ring diameter, presents superior rate performance and enduring cycle stability. It even maintains stable cycling for 2000 cycles at −40 ℃. In-situ electrochemical quartz crystal microbalance tests reveal the energy storage mechanism of BB-COF, in which H+ storage is followed by Zn2+ storage

Avian Influenza (H5N1) Virus in Waterfowl and Chickens, Central China

In 2004, 3 and 4 strains of avian influenza virus (subtype H5N1) were isolated from waterfowl and chickens, respectively, in central People’s Republic of China. Viral replication and pathogenicity were evaluated in chickens, quails, pigeons, and mice. We analyzed the sequences of the hemagglutinin and neuraminidase genes of the isolates and found broad diversity among them

Hsa-miR-196a2 Rs11614913 Polymorphism Contributes to Cancer Susceptibility: Evidence from 15 Case-Control Studies

BACKGROUND: MicroRNAs (miRNAs) are a family of endogenous, small and noncoding RNAs that negatively regulate gene expression by suppressing translation or degrading mRNAs. Recently, many studies investigated the association between hsa-miR-196a2 rs11614913 polymorphism and cancer risk, which showed inconclusive results. METHODOLOGY/PRINCIPAL FINDINGS: We conducted a meta-analysis of 15 studies that included 9,341 cancer cases and 10,569 case-free controls. We assessed the strength of the association, using odds ratios (ORs) with 95% confidence intervals (CIs). Overall, individuals with the TC/CC genotypes were associated with higher cancer risk than those with the TT genotype (OR=1.18, 95% CI=1.03-1.34, P<0.001 for heterogeneity test). In the stratified analyses, we observed that the CC genotype might modulate breast cancer risk (OR=1.11, 95%CI=1.01-1.23, Pheterogeneity=0.210) and lung cancer risk (OR=1.25, 95%CI=1.06-1.46, Pheterogeneity=0.958), comparing with the TC/TT genotype. Moreover, a significantly increased risk was found among Asian populations in a dominant model (TC/CC versus TT, OR=1.24, 95% CI=1.07-1.43, Pheterogeneity=0.006). CONCLUSIONS: These findings supported that hsa-miR-196a2 rs11614913 polymorphism may contribute to the susceptibility of cancers

The DNA Repair Gene APE1 T1349G Polymorphism and Risk of Gastric Cancer in a Chinese Population

Background: Apurinic/apyrimidinic endonuclease 1 (APE1) has a central role in the repair of apurinic apyrimidic sites through both its endonuclease and its phosphodiesterase activities. A common APE1 polymorphism, T1349G (rs3136820), was previously shown to be associated with the risk of cancers. Objective: We hypothesized that the APE1 T1349G polymorphism is also associated with risk of gastric cancer. Methods: In a hospital-based case-control study of 338 case patients with newly diagnosed gastric cancer and 362 cancerfree controls frequency-matched by age and sex, we genotyped the T1349G polymorphism and assessed its associations with risk of gastric cancer. Results: Compared with the APE1 TT genotype, individuals with the variant TG/GG genotypes had a significantly increased risk of gastric cancer (odds ratio = 1.69, 95 % confidence interval = 1.19–2.40), which was more pronounced among subgroups of aged #60 years, male, ever smokers, and ever drinkers. Further analyses revealed that the variant genotypes were associated with an increased risk for diffuse-type, low depth of tumor infiltration (T1 and T2), and lymph node metastasis gastric cancer. Conclusions: The APE1 T1349G polymorphism may be a marker for the development of gastric cancer in the Chinese population. Larger studies are required to validate these findings in diverse populations

Transcriptome Sequencing and Characterization for the Sea Cucumber Apostichopus japonicus (Selenka, 1867)

Background: Sea cucumbers are a special group of marine invertebrates. They occupy a taxonomic position that is believed to be important for understanding the origin and evolution of deuterostomes. Some of them such as Apostichopus japonicus represent commercially important aquaculture species in Asian countries. Many efforts have been devoted to increasing the number of expressed sequence tags (ESTs) for A. japonicus, but a comprehensive characterization of its transcriptome remains lacking. Here, we performed the large-scale transcriptome profiling and characterization by pyrosequencing diverse cDNA libraries from A. japonicus. Results: In total, 1,061,078 reads were obtained by 454 sequencing of eight cDNA libraries representing different developmental stages and adult tissues in A. japonicus. These reads were assembled into 29,666 isotigs, which were further clustered into 21,071 isogroups. Nearly 40 % of the isogroups showed significant matches to known proteins based on sequence similarity. Gene ontology (GO) and KEGG pathway analyses recovered diverse biological functions and processes. Candidate genes that were potentially involved in aestivation were identified. Transcriptome comparison with the sea urchin Strongylocentrotus purpuratus revealed similar patterns of GO term representation. In addition, 4,882 putative orthologous genes were identified, of which 202 were not present in the non-echinoderm organisms. More than 700 simple sequence repeats (SSRs) and 54,000 single nucleotide polymorphisms (SNPs) were detected in the A. japonicu