Thermal Magnetic Hysteresis in a Copper–Gadolinium–Radical Chain Compound

Magnetic bistability spanning over a temperature domain of 40 K can result from a small structural deformation of the gadolinium aminoxyl coordination. This is illustrated for a nitronyl nitroxide 3d–4f chain, [Ln­(hfac)₃Cu­(hfac)₂(NIT-Pyrim)₂] (Ln^III = Gd, Dy), which is the first example of a bistable lanthanide-based complex

Structure and Bioassay of Triterpenoids and Steroids Isolated from <i>Sinocalamus affinis</i>

Five triterpenoids with a new 25-norfern carbon skeleton (<b>1</b>–<b>5</b>), a lupane triterpenoid (<b>6</b>), and four 20<b>-</b>hydroxyprogesterone acyl esters (<b>7</b>–<b>10</b>), together with 23 known compounds, were isolated from the stem (with skin removed) of <i>Sinocalamus affinis</i>. The absolute configuration of compound <b>1</b> was confirmed by single-crystal X-ray crystallographic analysis using anomalous scattering of Cu Kα radiation. Compounds <b>1</b>–<b>5</b> exhibited inhibitory activity against protein tyrosine phosphatase 1B

Structure and Bioassay of Triterpenoids and Steroids Isolated from <i>Sinocalamus affinis</i>

Five triterpenoids with a new 25-norfern carbon skeleton (<b>1</b>–<b>5</b>), a lupane triterpenoid (<b>6</b>), and four 20<b>-</b>hydroxyprogesterone acyl esters (<b>7</b>–<b>10</b>), together with 23 known compounds, were isolated from the stem (with skin removed) of <i>Sinocalamus affinis</i>. The absolute configuration of compound <b>1</b> was confirmed by single-crystal X-ray crystallographic analysis using anomalous scattering of Cu Kα radiation. Compounds <b>1</b>–<b>5</b> exhibited inhibitory activity against protein tyrosine phosphatase 1B

Single Cell Gene Profiling Revealed Heterogeneity of Paracrine Effects of Bone Marrow Cells in Mouse Infarcted Hearts

<div><p>It is now recognized that transplantation of bone marrow cells (BMCs) into infarcted hearts has the capacity to improve the cardiac function through paracrine effects. However, detailed expression levels of paracrine factors in BMCs in infarcted hearts are poorly described. By use of laser capture microdissection combined with real-time PCR, we depicted the expression profiles of paracrine factors in infarcted hearts versus normal hearts. Consistent with the <i>in vivo</i> observation, a similar expression pattern was evidenced in cultured BMCs. Furthermore, BMCs displayed heterogeneity of paracrine effects in infarcted hearts as analyzed at the single cell level using single cell PCR. Interestingly, the CD45⁺ subpopulation showed higher expression levels of angiogenic factors compared to other subpopulations. Finally, most angiogenic factors were induced under the microenvironment of infarction. Our study demonstrated the heterogeneity of paracrine effects in BMCs at single cell level in infarcted hearts, highlighting preferential expression of angiogenic factors in the CD45⁺ subpopulation. These findings broaden our understanding of paracrine effects of BMCs <i>in vivo</i>, and offer new insights into BMCs therapy in myocardial infarction (MI).</p></div

The expression levels of paracrine factors of bone marrow derived CD45⁺ cells in infarcted hearts versus normal hearts.

<p>(A) Considerable amount of paracrine factors of CD45⁺ cells were upregulated in infarcted hearts. (B) Factors without significant changes. (C) 4 factors were downregulated in response to myocardial infarction. (n = 8 per each group).</p

Visible-Light-Mediated Radical Aryldifluoroacetylation of Alkynes with Ethyl Bromodifluoroacetate for the Synthesis of 3‑Difluoroacetylated Coumarins

A mild and efficient method for the synthesis of 3-difluoroacetylated coumarins through visible-light-promoted aryldifluoroacetylation of alkynes with ethyl bromodifluoroacetate has been developed. The reaction allows the direct formation of C_sp²–CF₂COOEt and C–C bonds via a proposed tandem radical cyclization process

Unprecedented Nitronyl Nitroxide Bridged 3d–4f Complexes: Structure and Magnetic Properties

Two novel 2p–3d–4f compounds, {Ln­(hfac)₃[Cu­(hfac)₂]₃(NITPhPyrim)₂} [Ln = Gd (<b>1</b>), Dy (<b>2</b>)], have been obtained by reacting phenyl pyrimidyl nitronyl nitroxide with Cu­(hfac)₂ and Ln­(hfac)₃. These two compounds are the first examples of two-dimensional 3d–4f complexes bridged by nitronyl nitroxide radicals. Overall ferromagnetic behaviors were observed in both compounds

Heart Function Was Improved by BMCs Injection.

<p>(A) Representative images of M-mode echocardiogram of infarcted hearts with PBS or BMCs injection at pre-surgery, day 1, 4 or 10. (B) Quantification of fractional shortening (%) at different time points in both groups. *P<0.05 versus PBS injection group, n = 8. (C) Representative images of HE staining 5 days after surgery from both groups. Magnification is 100×. (D) Quantification on histological sections from PBS or BMCs injected hearts. Values are means±SEM. n = 8 per group. *P<0.05 versus PBS.</p

BMCs displayed heterogeneity regarding paracrine effects in infarcted hearts.

<p>(A) A heat map showing that gene expression levels of different paracrine factors from 300 individual BMCs collected from infarcted hearts. (B–J) Population distribution plots (horizontal axis represents expression level; vertical axis represents percentage of total cell population) uncovered that single BMCs collected from infarcted hearts possessed considerable heterogeneity with respect to synthesis of paracrine factors.</p

Unprecedented Nitronyl Nitroxide Bridged 3d–4f Complexes: Structure and Magnetic Properties

Two novel 2p–3d–4f compounds, {Ln­(hfac)₃[Cu­(hfac)₂]₃(NITPhPyrim)₂} [Ln = Gd (<b>1</b>), Dy (<b>2</b>)], have been obtained by reacting phenyl pyrimidyl nitronyl nitroxide with Cu­(hfac)₂ and Ln­(hfac)₃. These two compounds are the first examples of two-dimensional 3d–4f complexes bridged by nitronyl nitroxide radicals. Overall ferromagnetic behaviors were observed in both compounds