Multiple Associations of Clinicopathological Characteristics and Risk Factors of Colorectal Cancer in the Iranian Population

Background: Previous studies have demonstrated that clinicopathological features of colorectal cancer (CRC) could be diverse in different CRC patients groups. The present study aimed to analyze the association between clinicopathological characteristics and the risk factors in different CRC patients groups, which is categorized by sex, family history, age, and also primary tumor site in the Iranian CRC patients. Method: In this cross-sectional study, we included 304 patients with CRC. The data of clinicopathological features were collected from documented pathology reports. Subsequently, we carried out multiple analyses to discover the association among these elements. Results: Our analysis demonstrated that there was a significant difference between men and women regarding the mean age at diagnosis, tumor locations, mean size of tumors, positive family history, smoking status, and physical activity (P <0.05). Out of all the patients, 22.4% had a positive family history of cancer. The patients with a positive family history just have lower mean age, body mass index (BMI), and higher physical activity compared with patients without family history of cancer (P <0.001). 31.9% of the patients were in the age group of below 55 and 68.1% were in the age group of 55. The majority of our patients in 0.05). Conclusion: Gaining information about the association between clinicopathological characteristics and the risk factors in CRC could provide a better understanding of disease pathogenesis and consequently, improve the management of diseases

Enhanced anticancer potency of hydroxytyrosol and curcumin by PLGA-PAA nano-encapsulation on PANC-1 pancreatic cancer cell line

Baradaran, Behzad/0000-0002-8642-6795; Goleij, Pouya/0000-0002-2213-497XWOS:000612051700001PubMed: 33496383Many chemotherapeutic regimens have been investigated for advanced unresectable and metastatic pancreatic cancer (PC), but with only minimal improvement in survival and prognosis. Here, we investigated anti-cancer function of free and nano-encapsulated hydroxytyrosol (Hyd) and curcumin (Cur), and its combinations (Hyd-Cur) on PANC-1 cell line. The poly lactide-co-glycolide-co-polyacrylic acid (PLGA-co-PAA) nano-encapsulated Hyd and Cur were synthesized, and MTT assay was performed to evaluate cytotoxic effects of free and nano-encapsulated Hyd, Cur, and Hyd-Cur. Effects of free and nano-encapsulated Hyd, Cur, and Hyd-Cur were evaluated on viability, migration, morphological alterations, colony formation, and apoptosis on PANC-1 cells. We observed that free and nano-encapsulated Hyd, Cur, and Hyd-Cur significantly increased apoptosis rates as well as significantly decreased viability, migration, and colony formation in PANC-1 cells. According to our results, Hyd-Cur combination and nano-encapsulation therapy exerts more profound apoptotic and anti-proliferative effects on PANC-1 cells than free Hyd or Hyd monotherapy