Frequency of Different Ligament Tears in Knee Injury On Magnetic Resonance Imaging

Background: MRI had been useful in the diagnosis of ligament injuries and the tears were detected by non-invasive procedure. Objective: To determine the frequency of different ligament tears in knee injury on Magnetic Resonance Imaging. Methods: A descriptive cross-sectional was conducted with the sample size of 206 patients of both genders by selecting the convenient sampling from Ghurki Trust Teaching Hospital, Lahore. Out of 206 patients, 157 were males while 49 were females. Data was analyzed with the help of SPSS version 24. The results were derived by mean, frequency and standard deviation. Results: Findings shows that among 206 patients, with in age limit of 12 years to 70 years. 157(76.2%) were males and 49(23.7%) were female while 96(46.6%) were presented with ACL tear, 19(9.2%) were presented with PCL tears, 51(25.7%) were presented with MCL tears, 33(16.0%) patients were presented with LCL tears and all of these 206 patients were suffering from pain. Conclusion: We concluded that males are more prevalent than females and in this population the incidence of ACL tears is more than other ligament tears. Hence, ACL is proved to be the most injured ligament. Keywords: Anterior cruciate ligament, Posterior cruciate ligament, Medial collateral ligament, Lateral collateral ligament and Magnetic resonance imaging. DOI: 10.7176/JHMN/71-06 Publication date: February 29th 202

Design, and synthesis of selectively anticancer 4-cyanophenyl substituted thiazol-2-ylhydrazones

Cyclization of substituted thiosemicarbazones with α-bromo-4-cyanoacetophenone allows rapid single-step sustainable syntheses of 4-cyanophenyl-2-hydrazinylthiazoles libraries (30 examples, 66–79%). All show anticancer efficacy against HCT-116 and MCF-7 carcinoma cell lines with the majority being more active than cisplatin positive controls. The compounds 2-(2-(2-hydroxy-3-methylbenzylidene) hydrazinyl)-4-(4-cyanophenyl)thiazole (3f) and 2-(2-((pentafluorophenyl)methylene)-hydrazinyl)-4-(4-cyanophenyl) thiazole (3a′) show optimal GI50 values (1.0 ± 0.1 μM and 1.7 ± 0.3 μM) against MCF-7 breast cancer cells. Against colorectal carcinoma HCT-116 cells, (2-(2-(3-bromothiophen-2yl)methylene)hydrazinyl)-4-(4-cyanophenyl)thiazole (3b′), 2-(2-(2-hydroxy-3-methylbenzylidene) hydrazinyl)-4-(4-cyanophenyl)thiazole (3f), 2-(2-(2,6-dichlorobenzylidene)hydrazinyl)-4-(4-cyanophenyl)thiazole (3f) and 2-(2-(1-(4-fluorophenyl)ethylidene)hydrazinyl)-4-(4-cyanophenyl) thiazole (3w) are the most active (GI50 values: 1.6 ± 0.2, 1.6 ± 0.1, 1.1 ± 0.5 and 1.5 ± 0.8 μM respectively). Control studies with MRC-5 cells indicate appreciable selectivity towards the cancer cells targeted. Significant (p < 0.005) growth inhibition and cytotoxicity effects for the thiazoles 3 were corroborated by cell count and clonogenic assays using the same cancer cell lines at 5 and 10 μM agent concentrations. Cell cycle, caspase activation and Western blot assays demonstrated that compounds 3b′ and 3f induce cancer cell death via caspase-dependent apoptosis. The combination of straight forward synthesis and high activity makes the thiazoles 3 an interesting lead for further development

Impact of different levels of zinc and nitrogen on growth, productivity, and quality of aromatic rice cultivated under various irrigation regimes in two districts of Pakistan

Rice is a staple food for more than 50% of the global population and it is one of the most valuable cereal crops. To fulfill the dietary requirement of the ever-growing world population, an increase in per-unit production of rice is direly required. In Pakistan, it stands as the 2nd in consumption after wheat, which is a staple food. A huge gap is observed between yield potential and actual yield of the aromatic rice cultivars at a farmer-field level. The significant limitations responsible for this gap are shortage of irrigation water, inappropriate application of fertilizers, less plant population, deficiency of micronutrients, and improper and poor plant protection measures. A field study was planned to assess the yield response and quality attributes of aromatic rice to three levels of zinc (Zn) and nitrogen (N) under three irrigation regimes (8-, 12-, and 16-acre inches) in the Sheikhupura and Sargodha districts of Pakistan. Irrigation treatments significantly influenced the growth, yield, and quality attributes; however, maximum improvement was observed by the application of irrigation at 12-acre inches. Among the Zn treatments, application of Zn at 10 kg ha–1 was observed to be more responsive to improving the growth and quality parameters of aromatic rice crops. In the case of N treatments, application of N at 140 kg ha–1 produced the maximum total tillers, as well as productive tillers per hill, spikelets per panicle, leaf area index, leaf area duration, crop growth rate, total dry matter, harvest index, kernel length, kernel width, and 1,000-kernel weight. Application of N at 140 kg ha–1 not only improved the growth attributes but also increased the net assimilation rate, photosynthetically active radiation, and radiation use efficiency, with respect to total dry matter and kernel yield. The maximum percentage of normal kernels and minimum percentage of opaque, abortive, and chalky kernels were also recorded by application of N at 140 kg ha–1. The outcomes of current experiments depicted that application of irrigational water, zinc, and nitrogen at 12-acre inches, 10, and 140 kg ha–1, respectively, are responsible to achieve maximum resource utilization efficiency, along with increased yield and quality of rice

The Effect of Cultural Heritage Tourism on Tourist Word of Mouth: The Case of Lok Versa Festival, Pakistan

Festivals are the most viable source of tourism promotion and provide recognition to different cultures and communities. This paper proposed and examined a holistic model of festival word of mouth (WOM), which is influenced by authenticity, promotion, loyalty, quality, and satisfaction. Accordingly, the current paper investigated the effect of the proposed model with reference to Lok Virsa handicrafts, the most famous festival of the Islamabad region in Pakistan. The findings revealed that the festival quality has direct impact on WOM and promotion. Promotion has a positive influence on loyalty, satisfaction, and WOM. Festival authenticity strongly influences promotion, quality, satisfaction, and WOM. Festival satisfaction is positively related to WOM and loyalty. Whereas, festival loyalty and WOM are significantly associated. The results suggest that festival organizers should deliver the claims and promises in the festival that they have made with tourists. This technique will harvest positive WOM and increase tourist re-visitation to upcoming festivals

SPORTAL: Searching for Public SPARQL Endpoints

There are hundreds of SPARQL endpoints on the Web, but finding an endpoint relevant to a client s needs is difficult: each endpoint acts like a black box, often without a description of its content. Herein we briefly describe Sportal: a system that collects meta-data about the content of endpoints and collects them into a central catalogue over which clients can search. Sportal sends queries to individual endpoints offline to learn about their content, generating a best-effort VoID description for each endpoint. These descriptions can then be searched and queried over by clients in the Sportal user interface, for example, to find endpoints that contain instances of a given class, or triples with a given predicate, or more complex requests such as endpoints with at least 1,000 images of people. Herein we give a brief overview of Sportal, its design and functionality, and the features that shall be demoed at the conference

سیرت رسول ﷺ کی روشنی میں دعوت دین کا طریقہ ،ایک تحقیقی مطالعہ: A RESEARCH REVIEW OF METHODOLOGY OF DAWAH IN THE LIGHT OF SEERAT E RASOOL

In fact,the word,"Dawah" is an Arabic word which means،"issuing a summon "but in general terms it means inviting and calling people/society towards the right path,the path of blessings in dunnia and aakhirah and letting them recognize ab the indefinite truth! This work can be done individually as well as collectively depending on the circumstances. Spreading the message in the light of Sira-e-Taiba in modern Muslim society as far as non-Muslim society is a matter of time. Its method and strategy how to invite if viewed in the light of Sira-e-Taiba, can be explained with great clarity and without any ambiguity. By implementing it, not only the Muslim society can be reformed but the non-Muslim society can also be adorned. By focusing on Sira-e-Taiba carefully, we may get the best guidance through which we can easily convey our religious thoughts, ideas and teachings to others. A careful study of Islamic history and teachings of the Prophet (may peace and blessings of Allah be upon him) reveals the best example of Dawah. No sample can be presented and no instruction can be given beyond Sira-e-Taiba. Time demands that during Dawah, all the rules and regulations that we find in the light of Sira-e-Taiba must be kept in mind.And in their light the work of Dawah must be extended not only towards the Muslim community but also towards the non-Muslim community. The methodology of Dawah in the light of Sira-e-Taiba is so beautiful and enduring that it cannot be compared. This article not only explains how a Muslim society can be decorated in the light of Sira-e-Taiba but In fact, the needs of the non-Muslim society, in the present era, have also been clearly articulated in the light of Sira-e-Taiba. My article will reveal the standard preaching/Dawah of Sira-e-Taiba in the light of Qur'an and Sunnah and will be so lasting, strong and full of arguments that the importance of this subject will be revealed to everyon

فتنہ کا قرآنی تصور: THE CONCEPT OF PUGNACITY IN QURAN

The Holy Quran is the last divine book of Allah Almighty. It is sent for guidance of Human beings.On one hand,The Holy Quran has designated the way of Guidance for human and other hand it also has provided the material for the avoidance of abjection and abberance. Among these teaching of the Holy Quran providing awareness about pugnacity, Is also one of them, pugnacity means trial, violence, punishment or that disaster through which the Muslim's capability is tested.Pugnacity is a term used in the Holy Quran, which is a very vast term.The Scholars keep very much capacity in the use of it.In common simple terms pugnacity means confusion which proves dangerous for Constant and correct belief.In the present times the muslims are facing many types of difficulties, various types of rumours are circling around.In ths horrible situation the Holy Quran does not deprive the beleivers of guidance and direction.In this article it is tried to describing that in which meanings " pugnacity " is used in the Holy Quran and&nbsp; how the Holy Quran&nbsp; guide us about&nbsp; coming pugnacities in future. &nbsp

SPORTAL: Profiling the Content of Public SPARQL Endpoints

Access to hundreds of knowledge bases has been made available on the Web through public SPARQL endpoints. Unfortunately, few endpoints publish descriptions of their content (e.g., using VoID). It is thus unclear how agents can learn about the content of a given SPARQL endpoint or, relatedly, find SPARQL endpoints with content relevant to their needs. In this paper, the authors investigate the feasibility of a system that gathers information about public SPARQL endpoints by querying them directly about their own content. With the advent of SPARQL 1.1 and features such as aggregates, it is now possible to specify queries whose results would form a detailed profile of the content of the endpoint, comparable with a large subset of VoID. In theory it would thus be feasible to build a rich centralised catalogue describing the content indexed by individual endpoints by issuing them SPARQL (1.1) queries; this catalogue could then be searched and queried by agents looking for endpoints with content they are interested in. In practice, however, the coverage of the catalogue is bounded by the limitations of public endpoints themselves: some may not support SPARQL 1.1, some may return partial responses, some may throw exceptions for expensive aggregate queries, etc. The authors\u27 goal in this paper is thus twofold: (i) using VoID as a bar, to empirically investigate the extent to which public endpoints can describe their own content, and (ii) to build and analyse the capabilities of a best-effort online catalogue of current endpoints based on the (partial) results collected.This publication was supported in part by a research grant from Science Foundation Ireland (SFI) under Grant Number SFI/12/RC/2289, by the Millennium Nucleus Center for Semantic Web Research under Grant NC120004, and by Fondecyt Grant No. 1114090