12 research outputs found
Crystalline Silicate Feature of the Vega-like star HD145263
We have observed the 8-13 m spectrum (R250) of the Vega-like star
candidate HD145263 using Subaru/COMICS. The spectrum of HD145263 shows the
broad trapezoidal silicate feature with the shoulders at 9.3 m and 11.44
m, indicating the presence of crystalline silicate grains. This detection
implies that crystalline silicate may also be commonly present around Vega-like
stars. The 11.44 m feature is slightly shifted to a longer wavelength
compared to the usual 11.2-3 m crystalline forsterite feature detected
toward Herbig Ae/Be stars and T Tauri stars. Although the peak shift due to the
effects of the grain size can not be ruled out, we suggest that Fe-bearing
crystalline olivine explains the observed peak wavelength fairly well.
Fe-bearing silicates are commonly found in meteorites and most interplanetary
dust particles, which originate from planetesimal-like asteroids. According to
studies of meteorites, Fe-bearing silicate must have been formed in asteroidal
planetesimals, supporting the scenario that dust grains around Vega-like stars
are of planetesimal origin, if the observed 11.44 m peak is due to
Fe-bearing silicates.Comment: accepted for Publication in ApJ
Employment-related difficulties and distressed living condition in patients with hepatitis B virus: A qualitative and quantitative study
SDSS J133401.39+331534.3: A New Subarcsecond Gravitationally Lensed Quasar
The quasar SDSS J133401.39+331534.3 at z = 2.426 is found to be a two-image
gravitationally lensed quasar with the image separation of 0.833. The object is
first identified as a lensed quasar candidate in the Sloan Digital Sky Survey
Quasar Lens Search, and then confirmed as a lensed system from follow-up
observations at the Subaru and University of Hawaii 2.2-meter telescopes. We
estimate the redshift of the lensing galaxy to be 0.557 based on absorption
lines in the quasar spectra as well as the color of the galaxy. In particular,
we observe the system with the Subaru Telescope AO188 adaptive optics with
laser guide star, in order to derive accurate astrometry, which well
demonstrates the usefulness of the laser guide star adaptive optics imaging for
studying strong lens systems. Our mass modeling with improved astrometry
implies that a nearby bright galaxy apart from the lensing galaxy is
likely to affect the lens potential.Comment: 24 pages, 6 figures. ApJ, in pres
Comparative studies to determine the selective inhibitors for P-glycoprotein and cytochrome P 4503A4
It has been suggested that cytochrome P450 3A4 (CYP3A4) and MDR1 P-glycoprotein (P-gp) act synergistically to limit the bioavailability of orally administered agents. In order to determine the relative role of these proteins, it is essential to identify a selective inhibitor for either P-gp or CYP3A4. In the present investigation, comparative studies were performed to examine the effect of inhibitors on the function of these proteins. The IC50 of P-gp function, determined by examining the inhibition of the transcellular transport of vinblastine across Caco-2 monolayers, was in the order PSC833 ≪ ketoconazole, verapamil ≪ N-(2(R)-hydroxy-1(S)-indanyl)-5-(2(S)-(1,1-dimethylethylaminocarbonyl)-4-(furo(2,3-b)pyridin-5-yl) methyl)piperazin-1-yl)-4(S)-hydroxy-2(R)-phenylmethylpentanamide (L-754,394). In contrast, the IC50 of CYP3A4 function, determined by examining the inhibition of the metabolism of midazolam by intestinal and liver microsomes, was in the order L-754,384 ≪ketoconazole≪ PSC 833 and verapamil. The ratio of IC50 for P-gp to that for CYP3A4 was more than 200 for L-754,394,60 ∼ 150 for ketoconazole, 1.5 for verapamil, and 0.05 for PSC 833. Collectively, it was demonstrated that PSC 833 and L-754,394 can be used as selective inhibitors of P-gp and CYP3A4, respectively
若年性関節リウマチに対する人工股関節再置換術の経験
著者版若年性関節リウマチ(JRA)に対する人工股関節再置換術(revision) について検討した.対象は,revisionを施行した3例5関節(全例男性,手術時平均年齢30歳)で,平均経過観察期間は6.0年,revision施行理由は機械的なTHAおよび人工骨頭の弛みが4関節,ポリエチレンライナーの脱転が1関節であった.1)臨床評価は日整会スコアが術前平均38点から70点に改善し,股関節可動域は屈曲が術前平均65°から95°へ,外転は術前平均15°から25°へ改善した.2)X線評価ではlooseningは認めず,clear zoneはsocket側では全例で認めず,stem側ではセメント使用の2関節の正面像でzone 1とzone 7に若干のclear lineを認めた.3)RAのclass分類では術前class IIIであった2例がclass IIへ改善していた.以上,JRAに対するrevisionでは骨量温存に努め,人工骨頭の耐久性を最も重視すべきだと考えられた