Metal aminocarboxylate coordination polymers with chain and layered structures

The synthesis and structures of metal aminocarboxylates prepared in acidic, neutral, or alkaline media have been explored with the purpose of isolating coordination polymers with linear chain and two-dimensional layered structures. Metal glycinates of the formulae [CoCl2(H2O)2(CO2CH2NH3)] (I), [MnCl2(CO2CH2NH3)2] (II), and [Cd3Cl6(CO2CH2NH3)4] (III) with one-dimensional chain structures have been obtained by the reaction of the metal salts with glycine in an acidic medium under hydro/solvothermal conditions. These chain compounds contain glycine in the zwitterionic form. 4-Aminobutyric acid transforms to a cyclic amide under such reaction conditions, and the amide forms a chain compound of the formula [CdBr2(C4H7NO)2] (IV). Glycine in the zwitterionic form also forms a two-dimensional layered compound of the formula [Mn(H2O)2(CO2CH2NH3)2]Br2 (V). 6-Aminocaproic acid under alkaline conditions forms layered compounds with metals at room temperature, the metal being coordinated both by the amino nitrogen and the carboxyl oxygen atoms. Of the two layered compounds [Cd{CO2(CH2)5NH2}2]·2H2O (VI) and [Cu{CO2(CH2)5NH2}2]·2H2O (VII), the latter has voids in which water molecules reside

LPG Gas Leakage Detection and Prevention System

Gas leakage has been a major concern in recent times. Though its usage has been extended in various industries, a small unattended leakage can lead to catastrophic damage. The objective of this project is to present the design of a cost effective automatic alarming system, which can detect and prevent liquefied petroleum gas leakage in various premises. This system alerts the user by sending him an SMS and alerting the neighbors by buzzer alarm after the gas leaks above setpoint1.The stepper motor is used to close the gas pipe valves. To reduce risks to human life, main power supply is cut off, if the gas leakage goes above setpoint2. This device ensures safety and prevents suffocation and explosion due to gas leakage. This project is implemented using ARM 7 processor and simulated using keil software

NON-HEPATIC HYPERAMMONEMIC COMA: A CASE REPORT

ABSTRACTWhile the most common cause of hyperammonemic (HA) coma is hepatic disorder, other rare etiologies to be considered include congenital causes,drug induced states, portosystemic shunts, and urinary tract infections with urea-splitting organisms. HA usually results from one of the followingthree mechanisms: A relative excessive nitrogen load on a normal functioning liver via the portal circulation (e.g., parenteral nutrition in a patientwith urea cycle defect); ammonia bypassing liver (e.g., congenital vascular malformations, portal hypertension in cirrhotic patients); or from impairedammonia metabolism. Herein, we describe a case of HA coma secondary to an interplay of multiple psychiatric drugs mainly sodium valproate andprobably an added effect by the lithium-induced hypothyroidism/myxedema.Keywords: Drug-induced, Hyperammonemia, Lithium, Myxedema, Valproic acid

Newly Diagnosed Papillary Craniopharyngioma With BRAF V600E Mutation Treated With Single-Agent Selective BRAF Inhibitor Dabrafenib: A Case Report

We report a case of a patient with newly diagnosed, locally extensive and cystic, suprasellar papillary craniopharyngioma successfully treated with single-agent Dabrafenib. The patient was symptomatic with gait imbalance with falls, lethargic episodes, fatigue and incontinence. Diagnostic imaging demonstrated a cystic suprasellar tumor extending into the third ventricle causing obstructive hydrocephalus. The tumor was partially debulked, and bilateral shunts were placed. NGS sequencing demonstrated BRAF V600E mutation, and the patient was prescribed dual agent Dabrafenib and Trametinib. However, due to insurance denial for Trametinib, he only received single-agent Dabrafenib (150mg BID). The treatment resulted in a major response (over two years), including reduction of the tumor cyst, and improvement of the clinical symptoms. No adverse events have been reported. The patient continues on Dabrafenib (150 mg BID) with a steady reduction in tumor size, and improvement in cognitive function leading to independent living

46XX pure gonadal dysgenesis with dysgerminoma along with leydig cells: a unique presentation

Authors report a unique case of 46XX gonadal dysgenesis, with dysgerminoma in one ovary and other streak ovary with hilar nests of leydig cells. It is exceptionally rare to find dysgerminoma in a dysgenetic gonad with no Y chromosome and so is the presence of leydig cells in the contralateral streak ovary in a patient with 46XX pure gonadal dysgenesis

The Antioxidant Enzyme Prdx1 Controls Neuronal Differentiation by Thiol-Redox-Dependent Activation of GDE2

SummaryThe six-transmembrane protein GDE2 controls the onset and progression of spinal motor neuron differentiation through extracellular glycerophosphodiester phosphodiesterase metabolism. Although this process is likely to be tightly regulated, the relevant mechanisms that modulate its activity are unknown. Here we show that the antioxidant scavenger peroxiredoxin1 (Prdx1) interacts with GDE2, and that loss of Prdx1 causes motor neuron deficits analogous to GDE2 ablation. Prdx1 cooperates with GDE2 to drive motor neuron differentiation, and this synergy requires Prdx1 thiol-dependent catalysis. Prdx1 activates GDE2 through reduction of an intramolecular disulfide bond that bridges its intracellular N- and C-terminal domains. GDE2 variants incapable of disulfide bond formation acquire independence from Prdx1 and are potent inducers of motor neuron differentiation. These findings define Prdx1 as a pivotal regulator of GDE2 activity and suggest roles for coupled thiol-redox-dependent cascades in controlling neuronal differentiation in the spinal cord

Organically templated rare earth sulfates with three-dimensional and layered structures

Amine-templated rare earth sulfates of the compositions: [Ln2(H2O)2(SO4)5][C2N2H10]2, I, with Ln=La, Pr or Nd, [Nd2(SO4)4(H2O)2][C4N2H12], II, [Ln2(SO4)4][C2N2H10], III, with Ln=La or Nd, [La2(SO4)4][C3N2H12], IV and [Ln2(SO4)4(H2O)4][C6N2H14]2[C2N2H8][SO4][H2O]3, with V, Ln=La, Pr or Nd, have been synthesized under hydrothermal conditions. Both I and II have three-dimensional architectures with I possessing eight-membered apertures surrounding 16-membered apertures, and II having 12 membered apertures. Both III and V have interesting layered structures with LnO3 layers possessing (6, 3) net topology and the amine located in between the layers. V has a layered structure wherein the SO4 tetrahedra and the LnO9 polyhedra join together to form (4, 4) net sheets, with two different amines as well as the sulfate ions residing in the interlamellar space

A simple single-source precursor route to the nanostructures of AlN, GaN and InN

In an effort to find a simple and common single-source precursor route for the group 13 metal nitride semiconductor nanostructures, the complexes formed by the trichlorides of Al, Ga and In with urea have been investigated. The complexes, characterized by X-ray crystallography and other techniques, yield the nitrides on thermal decomposition. Single crystalline nanowires of AlN, GaN and InN have been deposited on Si substrates covered with Au islands by using the complexes as precursors. The urea complexes yield single crystalline nanocrystals under solvothermal conditions. The successful synthesis of the nanowires and nanocrystals of these three important nitrides by a simple single-precursor route is noteworthy and the method may indeed be useful in practice

Serous effusions in Burkitt lymphomas: a report of two paediatric cases with review of literature

The serosal cavity can be involved in many diseases, both benign and malignant. Such involvement is secondary to occurrence of disease at other sites. Lymphoma, although not a very common cause for serous effusion, is one of the most important one. The reason for serosal involvement in lymphomas has not been fully elucidated. These two cases highlight the importance of pleural and peritoneal fluid examination in the diagnosis of lymphoma. There is correlation between fluid examination and subsequent cytological and histopathological studies, with immunohistochemical confirmation. A comprehensive understanding of the mechanism of serosal involvement in lymphomas may lead to early diagnosis, better patient management and also development of newer treatment modalities for the same