EFFECT OF VARMAM THERAPY IN SANTHU VATHAM (OSTEO ARTHRITIS–KNEE JOINT)-A SINGLE CASE STUDY

Santhu vatham is a vatha disease mentioned in the Siddha text book Yugi vaidhya chindhamani. The clinical features can be equated to osteo arthritis of knee joint. Varmam therapy is one of the external therapies mentioned in Siddha literature. A 68 y old male from chennai reported to the varmam, narambiyal matrum enbumurivu OPD of Siddha Central Research Institute (SCRI) on 2.5.2015 with chief complaints of pain and swelling in both knee joints since 5 y. He was given varmam therapy. Varma points are points where the pranan, ie, vital energy of our body is concentrated (residing). The treatment is given for 45 d for once in 2 d for 15 min. The pain was assessed using visual analogue score before and after treatment. The pain was markedly reduced after treatment. The range of movements of the knee joint was also improved

The role of halide ions in the anisotropic growth of gold nanoparticles: a microscopic, atomistic perspective

We provide a microscopic view of the role of halides in controlling the anisotropic growth of gold nanorods through a combined computational and experimental study. Atomistic molecular dynamics simulations unveil that Br(–) adsorption is not only responsible for surface passivation, but also acts as the driving force for CTAB micelle adsorption and stabilization on the gold surface in a facet-dependent way. The partial replacement of Br(–) by Cl(–) decreases the difference between facets and the surfactant density. Finally, in the CTAC solution, no halides or micellar structures protect the gold surface and further gold reduction should be uniformly possible. Experimentally observed nanoparticle's growth in different CTAB/CTAC mixtures is more uniform and faster as the amount of Cl(–) increases, confirming the picture from the simulations. In addition, the surfactant layer thickness measured on nanorods exposed to CTAB and CTAC quantitatively agrees with the simulation results

Engineered Exosomes for the Multimodal Imaging Directed Photo-Immunotherapy of Colorectal Cancer

Background: Rio Grande Valley experience severe cancer health disparity. A novel therapeutic modality may serve as better therapeutic option. Nanohybrids endowed with multifunctionality, longer circulation time, large surface area have emerged as an active preference for cancer research. However, rising concern of nanomaterials toxicity and scalability issues has slowed their translation to clinics. Exosomes (Exo) are endogenous endocytic origin 40-100 nm vesicles found in various body fluids, which in comparison to synthetic nanoparticles, are biodegradable, highly biocompatible as well as immunocompatible in nature. Although bulk isolation of exosomes from human body fluids is still a problem and engineering of exosomes to harness its potential is still in infancy. Methods: The Exo were isolated from dairy milk using EDTA precipitation method, and superparamagnetic iron oxide nanoparticles (MNPs) were synthesized by ammonium hydroxide co-precipitation method. The Exo were sonicated (60 sec) with MNPs and near-infrared (NIR) light-absorbing dye indocyanine green (ICG) and then incubated overnight at 37 oC. The characterization of ICG@Exo-MNPs was done using several techniques. The targeting nature of ICG@Exo-MNPs was determined on colorectal cancer cells SW480 and SW680. The phototransduction and in-vitro photothermal therapy were performed using 1W, 808 nm NIR laser. Results: The ICG@Exo-MNPs nanohybrid found to have size around 100 nm with good dispersity. The coating of exosomes and magnetic field actuation increased the targeting efficacy of ICG@Exo-MNPs in colorectal cancer cells by 10% in SW40 and 30% in SW680. ICG@Exo-MNPs killed the SW480 cells to more than 80% within 2 min. of NIR light irradiation. Conclusions: This study shows enhanced photothermal therapeutic behavior of ICG@Exo-MNPs for near-infrared fluorescence imaging directing killing of colorectal cancer cells

Response of bio-regulators to yield and quality of Indian mustard (Brassica juncea L. Czernj. and Cosson) under different irrigation environments

A field study was conducted during rabi seasons of 2008 and 2009 to evaluated of productivity of Indian mustard (Brassica juncea L.) by foliar spray of bio-regulators under different irrigation environments. Amongst treatments, the application of sufficient irrigation water (four irrigations) recorded the highest number siliqua per plant, higher number of seeds per siliqua, 1000 seed weight and yields as compared to all other irrigation treatments. Results show that an increased in seed yield of 92.40 and 39.37 % under sufficient irrigation and limitedwater condition in 2008 and 93.34% and 40.31% in 2009, respectively over deficient irrigation conditions, foliar sprays of 100 ppm thioglycollic acid at initiation of branching were recorded highest yield attributes and yields. Similarly, 500 ppm of thiourea at initiation of branching and flowering stages also gave second best highest yield attributes and yields as compared to all other bio-regulators spray stages. However, bio-regulators sprays were not recorded any significant effect on oil and protein content. The results were concluded that economic feasibility to improve productivity of Indian mustard with four irrigations levels and sprays of 100 ppm thioglycollic acid and 500 ppm of thiourea at initiation of branching and flowering stages under hyper arid environment

Comparative study of titanium elastic nailing versus hip spica in treatment of femoral shaft fractures in children

Background: There is no consensus on treatment of closed femoral-shaft fractures in children. We compared hip spica cast with titanium elastic nailing (TEN) in the treatment of femoral-shaft fractures in children.Methods: Study was conducted at SMS Medical College, Jaipur (Rajasthan). Out of 90 Patients of diaphyseal fracture femur, 45were treated conservatively by spica cast and 45 were treated with TEN. Follow up done regularly up to twelve months of injury with taking into account, various parameters.Results: All diaphyseal fractures of femur healed, whether treated conservatively by spica cast or treated operatively with TEN. The time of union and weight bearing was less in operative group as comparative to spica cast group. Ten patients (22.22%) in spica group compared to three patients (6.66%) in operative group had malunion and two patients (4.4%) in spica group compared none in operative group had delayed union.Conclusions: Results of TEN turned out to be far superior to traction and spica cast treatment in paediatric femoral fractures. Rate of complications was far low with operative than conservative Treatment

No difference in patient reported outcomes, laxity, and failure rate after revision ACL reconstruction with quadriceps tendon compared to hamstring tendon graft: a systematic review and meta-analysis

Purpose: The purpose of this study was to synthesize and quantitatively assess the outcomes of ACL Revision using a quadriceps tendon (QT) graft and to compare them with those of ACL Revisions performed with hamstring tendons (HT) graft. Methods: A comprehensive search based on the PRISMA protocol was performed across PubMed, Scopus, Embase, and Cochrane Library from inception until February 2022. Clinical studies reporting the outcomes of ACL Revision with QT autograft were included. Subjective and Objective IKDC, Tegner activity level, Lysholm knee score, KOOS score, VAS for pain, knee laxity (KT-1000/2000 arthrometer, Lachman test, and pivot-shift test), and graft failure were assessed. A systematic review and meta-analysis were performed and a quality assessment of the included studies was carried out with the MINORS score. Results: Seven studies met the selection criteria and were included in the systematic review for the qualitative synthesis of data. A pooled mean of all the variables was provided for the 7 studies, while 3 studies included a control group of ACL Revision with HT and were included in a meta-analysis. A total of 420 participants with a mean age of 28.9 ± 10.5 years and a mean postoperative follow-up of 39.3 ± 16.4 months were assessed. Of these, 277 patients underwent ACL Revision with QT and 143 patients underwent ACL Revision with HT. In the QT group, average graft failure was 9.8% compared to 17.4% in the HT group. KOOS Sport and pivot-shift test showed better postoperative outcomes in QT than HT, although it was not statistically significant (p = 0.052). Conclusion: The QT autograft was associated with an improved trend of rotatory laxity, PROMs and failure rate compared to HT autograft after revision ACL reconstruction. The QT autograft for revision ACL reconstruction is supported by the current literature. It is a viable graft that should be considered for both primary and revision ACL reconstruction. Level of evidence: Level IV

Sharp change over from compound nuclear fission to shape dependent quasi fission

Fission fragment mass distribution has been measured from the decay of $^{246}$Bk nucleus populating via two entrance channels with slight difference in mass asymmetries but belonging on either side of the Businaro Gallone mass asymmetry parameter. Both the target nuclei were deformed. Near the Coulomb barrier, at similar excitation energies the width of the fission fragment mass distribution was found to be drastically different for the $^{14}$N + $^{232}$Th reaction compared to the $^{11}$B + $^{235}$U reaction. The entrance channel mass asymmetry was found to affect the fusion process sharply.Comment: 4 pages,6 figure

Studies of structural, magnetic and dielectric properties of X-type Barium Zinc hexaferrite Ba2Zn2Fe28O46 powder prepared by combustion treatment method using ginger root extract as a green reducing agent

Various quantities of ginger (Zingiber officinale) root extract were used to prepare X-type Barium–Zinc hexaferrite with the chemical composition Ba2Zn2Fe28O46. The powders were prepared using a combustion treatment method, being pre-heated at 550 °C for 4 h with the ginger as a fuel, followed by final heating to 900 °C for 5 h and natural cooling to room temperature to obtain Ba2Zn2Fe28O46 hexagonal ferrite powder. The phase composition of heated powder samples was investigated by X-ray diffraction (XRD), indicating the formation of a mixture of X-type and hematite (α-Fe2O3). Up to 82.6%, X-ferrite was formed at 900 °C with 52.5 g of ginger root extract. Dielectric analysis of the prepared samples shows the frequency-dependent phenomena. All samples were hard magnets, with coercivity values (HC) between 262.2 and 318.3 kA m−1, and squareness ratios > 0.5. The sample prepared with 52.5 g ginger root extract possesses the highest value of saturation magnetisation (MS = 33.87 Am2 kg−1) in comparison with the other prepared samples. Therefore, ginger was shown to be a useful natural plant extract as a reducing fuel for the low-temperature synthesis of X-ferrites. The sample prepared with 35 g ginger root extract shows a broad loss tangent resonance peak between 10 kHz and 100 kHz, while other samples show loss tangent resonance peaks between 300 kHz and 2 MHz frequency range