235 research outputs found
Synchronous and Asynchronous Mott Transitions in Topological Insulator Ribbons
We address how the nature of linearly dispersing edge states of two
dimensional (2D) topological insulators evolves with increasing
electron-electron correlation engendered by a Hubbard like on-site repulsion
in finite ribbons of two models of topological band insulators. Using an
inhomogeneous cluster slave rotor mean-field method developed here, we show
that electronic correlations drive the topologically nontrivial phase into a
Mott insulating phase via two different routes. In a synchronous transition,
the entire ribbon attains a Mott insulating state at one critical that
depends weakly on the width of the ribbon. In the second, asynchronous route,
Mott localization first occurs on the edge layers at a smaller critical value
of electronic interaction which then propagates into the bulk as is further
increased until all layers of the ribbon become Mott localized. We show that
the kind of Mott transition that takes place is determined by certain
properties of the linearly dispersing edge states which characterize the
topological resilience to Mott localization.Comment: 4+ pages, 5 figure
Expressed in the yeast Saccharomyces cerevisiae, human ERK5 is a client of the Hsp90 chaperone that complements loss of the Slt2p (Mpk1p) cell integrity stress-activated protein kinase
ERK5 is a mitogen-activated protein (MAP) kinase regulated in human cells by diverse mitogens and stresses but also suspected of mediating the effects of a number of oncogenes. Its expression in the slt2Delta Saccharomyces cerevisiae mutant rescued several of the phenotypes caused by the lack of Slt2p (Mpk1p) cell integrity MAP kinase. ERK5 is able to provide this cell integrity MAP kinase function in yeast, as it is activated by the cell integrity signaling cascade that normally activates Slt2p and, in its active form, able to stimulate at least one key Slt2p target (Rlm1p, the major transcriptional regulator of cell wall genes). In vitro ERK5 kinase activity was abolished by Hsp90 inhibition. ERK5 activity in vivo was also lost in a strain that expresses a mutant Hsp90 chaperone. Therefore, human ERK5 expressed in yeast is an Hsp90 client, despite the widely held belief that the protein kinases of the MAP kinase class are non-Hsp90-dependent activities. Two-hybrid and protein binding studies revealed that strong association of Hsp90 with ERK5 requires the dual phosphorylation of the TEY motif in the MAP kinase activation loop. These phosphorylations, at positions adjacent to the Hsp90-binding surface recently identified for a number of protein kinases, may cause a localized rearrangement of this MAP kinase region that leads to creation of the Hsp90-binding surface. Complementation of the slt2Delta yeast defect by ERK5 expression establishes a new tool with which to screen for novel agonists and antagonists of ERK5 signaling as well as for isolating mutant forms of ERK5
Helical edge states in multiple topological mass domains
The two-dimensional topological insulating phase has been experimentally
discovered in HgTe quantum wells (QWs). The low-energy physics of
two-dimensional topological insulators (TIs) is described by the
Bernevig-Hughes-Zhang (BHZ) model, where the realization of a topological or a
normal insulating phase depends on the Dirac mass being negative or positive,
respectively. We solve the BHZ model for a mass domain configuration, analyzing
the effects on the edge modes of a finite Dirac mass in the normal insulating
region (soft-wall boundary condition). We show that at a boundary between a TI
and a normal insulator (NI), the Dirac point of the edge states appearing at
the interface strongly depends on the ratio between the Dirac masses in the two
regions. We also consider the case of multiple boundaries such as NI/TI/NI,
TI/NI/TI and NI/TI/NI/TI.Comment: 11 pages, 15 figure
Helical edge states in multiple topological mass domains
The two-dimensional topological insulating phase has been experimentally
discovered in HgTe quantum wells (QWs). The low-energy physics of
two-dimensional topological insulators (TIs) is described by the
Bernevig-Hughes-Zhang (BHZ) model, where the realization of a topological or a
normal insulating phase depends on the Dirac mass being negative or positive,
respectively. We solve the BHZ model for a mass domain configuration, analyzing
the effects on the edge modes of a finite Dirac mass in the normal insulating
region (soft-wall boundary condition). We show that at a boundary between a TI
and a normal insulator (NI), the Dirac point of the edge states appearing at
the interface strongly depends on the ratio between the Dirac masses in the two
regions. We also consider the case of multiple boundaries such as NI/TI/NI,
TI/NI/TI and NI/TI/NI/TI.Comment: 11 pages, 15 figure
Stem cell secretome-rich nanoclay hydrogel: a dual action therapy for cardiovascular regeneration†
A nanocomposite hydrogel with photocrosslinkable micro-porous networks and a nanoclay component was successfully prepared to control the release of growth factor-rich stem cell secretome. The proven pro-angiogenic and cardioprotective potential of this new bioactive system provides a valuable therapeutic platform for cardiac tissue repair and regeneration
Search for universality in one-dimensional ballistic annihilation kinetics
We study the kinetics of ballistic annihilation for a one-dimensional ideal
gas with continuous velocity distribution. A dynamical scaling theory for the
long time behavior of the system is derived. Its validity is supported by
extensive numerical simulations for several velocity distributions. This leads
us to the conjecture that all the continuous velocity distributions \phi(v)
which are symmetric, regular and such that \phi(0) does not vanish, are
attracted in the long time regime towards the same Gaussian distribution and
thus belong to the same universality class. Moreover, it is found that the
particle density decays as n(t)~t^{-\alpha}, with \alpha=0.785 +/- 0.005.Comment: 8 pages, needs multicol, epsf and revtex. 8 postscript figures
included. Submitted to Phys. Rev. E. Also avaiable at
http://mykonos.unige.ch/~rey/publi.html#Secon
The Harmonic Measure for critical Potts clusters
We present a technique, which we call "etching," which we use to study the
harmonic measure of Fortuin-Kasteleyn clusters in the Q-state Potts model for
Q=1-4. The harmonic measure is the probability distribution of random walkers
diffusing onto the perimeter of a cluster. We use etching to study regions of
clusters which are extremely unlikely to be hit by random walkers, having
hitting probabilities down to 10^(-4600). We find good agreement between the
theoretical predictions of Duplantier and our numerical results for the
generalized dimension D(q), including regions of small and negative q.Comment: 20 pages, 10 figure
Size estimation of injecting drug users (IDU) using multiplier method in five Districts of India
The HIV epidemic in Manipur, the highest HIV prevalence state of India, is primarily driven by injecting drug use. Reliable estimate of population size of injecting drug users (IDU) is critical for aiding HIV prevention program in the state to combat drug driven HIV epidemic. The study described multiplier method, an indirect technique of estimation of IDU size in five districts of Manipur, India making use of existing records of rapid intervention and care (RIAC) programs. Number of IDUs who accessed RIAC services during the past 12 months was taken as the benchmark data for the size estimation. The benchmark data were then multiplied by the inverse of the proportion of the IDUs who reported having accessed RIAC services during the same period to derive the sizes of IDU population in each study districts. The estimated sizes of IDU population in five districts were: 7353 (95% CI: 6759-8123) in Imphal West, 5806 (95% CI: 5635-6054) in Imphal East, 3816 (95% CI: 3571-4139) in Thoubal, 2615 (95% CI: 2528-2731) in Churachandpur and 2137 (95% CI: 1979-2343) in Bishenpur district. Multiplier method seems to be a feasible indirect technique which can be applied to estimate of IDU population using existing data from intervention programs in settings like Manipur where reliable size estimation of IDU population is lacking
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