The nuclear spectrum of the radio galaxy NGC 5128 (Centaurus A)

We present near-infrared spectra of the nuclear disk in the nearby radio galaxy NGC 5128 (Centaurus A). On the basis of the observed strengths of the [S III] 0.9532um and [Fe II] 1.2567um lines, we classify NGC 5128 as a LINER. Modeling of the strengths of these and additional lines suggests that the nuclear region is powered by shocks rather than photoionization.Comment: 12 pages including 2 figures, accepted by ApJ Letter

Stellar Populations at the Center of IC 1613

We have observed the center of the Local Group dwarf irregular galaxy IC 1613 with WFPC2 aboard the Hubble Space Telescope in the F439W, F555W, and F814W filters. We find a dominant old stellar population (aged ~7 Gyr), identifiable by the strong red giant branch (RGB) and red clump populations. From the (V-I) color of the RGB, we estimate a mean metallicity of the intermediate-age stellar population [Fe/H] = -1.38 +/- 0.31. We confirm a distance of 715 +/- 40 kpc using the I-magnitude of the RGB tip. The main-sequence luminosity function down to I ~25 provides evidence for a roughly constant SFR of approximately 0.00035 solar masses per year across the WFPC2 field of view (0.22 square kpc) during the past 250-350 Myr. Structure in the blue loop luminosity function implies that the SFR was ~50% higher 400-900 Myr ago than today. The mean heavy element abundance of these young stars is 1/10th solar. The best explanation for a red spur on the main-sequence at I = 24.7 is the blue horizontal branch component of a very old stellar population at the center of IC 1613. We have also imaged a broader area of IC 1613 using the 3.5-meter WIYN telescope under excellent seeing conditions. The AGB-star luminosity function is consistent with a period of continuous star formation over at least the age range 2-10 Gyr. We present an approximate age-metallicity relation for IC 1613, which appears similar to that of the Small Magellanic Cloud. We compare the Hess diagram of IC 1613 to similar data for three other Local Group dwarf galaxies, and find that it most closely resembles the nearby, transition-type dwarf galaxy Pegasus (DDO 216).Comment: To appear in the September 1999 Astronomical Journal. LaTeX, uses AASTeX v4.0, emulateapj style file, 19 pages, 12 postscript figures, 2 tables. 5 of the figures available separately via the WW

A meta‐analysis of toxicities related to hydroxycarbamide dosing strategies

Abstract Due to fear of short‐term toxicities, there is nonconsensus of hydroxycarbamide dosing strategy (escalated vs fixed‐dosing methods), which contributes to its suboptimal use. We performed a meta‐analysis to summarize the incidence rates of toxicities associated with both dosing methods. Summarized incidence rates could not be statistically compared between dosing methods due to sparse data. Summarized neutropenia and thrombocytopenia incidence rates were slightly higher when using escalated dosing than with fixed. Summarized reticulocytopenia was comparable. Summarized hepatic and renal toxicities’ incidence rates were slightly higher when using fixed doses than with escalated. We recommend diligent and transparent reporting of toxicities

Far-Ultraviolet Imaging of Jupiter's Aurora and the Io “Footprint”

Far-ultraviolet images of Jupiter from the Hubble Space Telescope Wide Field Planetary Camera 2 reveal polar auroral emissions at 300 kilometer resolution and three times higher sensitivity than previously achieved. Persistent features include a main oval containing most of the emission and magnetically connected to the middle magnetosphere, diffuse and variable emissions poleward of the main oval, and discrete emission from Io's magnetic footprint equatorward of the oval. The auroral emissions are variable, exhibit magnetic conjugacy, and are visible above the planet limb. All emissions approximately co-rotate with Jupiter except the Io “footprint,” which is fixed along Io's magnetic flux tube

Time-Resolved Observations of Jupiter's Far-Ultraviolet Aurora

Simultaneous imaging and spectroscopic observations of Jupiter's far-ultraviolet aurora covering half a jovian rotation were made on 31 May 1994. The Hubble Space Telescope Wide Field Planetary Camera 2 images revealed dramatic and rapidly changing auroral features, including discrete longitudinal structures along the auroral ovals, with variable contrast; a poleward offset in a north oval sector, showing equatorward motion near dusk; emissions polewards of the ovals, apparently co-rotating; and a bright event developing near the dawn limb. Viewing geometry effects explain the rotational intensity modulation observed by the International Ultraviolet Explorer, without intrinsic longitudinal asymmetries

Asteroid Trails in Hubble Space Telescope1 WFPC2 Images: First Results

Careful examination of 28,460 selected Wide Field and Planetary Camera 2 (WFPC2) long exposures from 1994, 1995, and early 1996 has revealed trails of 96 distinct moving objects. They have been reported to the International Astronomical Union's (IAU) Minor Planet Center for their asteroid database and a few have been identified with known asteroids and used to update their orbits. Most of the objects are new, as they are too faint to show up on ground-based surveys. The trails often show a characteristic curvature due to the parallax induced by HST's orbital motion during the exposures. Using ephemerides for HST, the distance to each object can be directly determined from the parallax contribution to the trail shapes. Based on these distances, constraints on the orbits, and photometry of the trails (16 <V< 24), most of the moving objects appear to be small, main-belt asteroids a few km in diameter. A few are known objects—three are potential Mars crossers. Modern wide-field CCD surveys detect asteroids nearly as faint as these (V< 21), but the corresponding absolute magnitudes are uncertain unless their orbits have been established. The detected objects span the absolute magnitude range 13.6 <H< 19.3 (His the symbol for absolute magnitude, not H-band). Statistics of the detections imply a reservoir of (3.1 ± 0.6) × 10^5such asteroids within 25° of the ecliptic. We find that the slope of the cumulative distribution of absolute magnitudes follows a power law N ∝ H^(0.2)to N ∝ H^(0.3)over this absolute magnitude range in the three distance ranges defined by the Palomar–Leiden survey. These are significantly shallower slopes than those inferred by the Palomar–Leiden survey or extrapolated from population studies of larger asteroids

Pregnancy and neonatal outcomes of COVID -19: coreporting of common outcomes from PAN-COVID and AAP-SONPM registries

Objective Few large cohort studies have reported data on maternal, fetal, perinatal and neonatal outcomes associated with severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection in pregnancy. We report the outcome of infected pregnancies from a collaboration formed early during the pandemic between the investigators of two registries, the UK and Global Pregnancy and Neonatal outcomes in COVID‐19 (PAN‐COVID) study and the American Academy of Pediatrics (AAP) Section on Neonatal–Perinatal Medicine (SONPM) National Perinatal COVID‐19 Registry. Methods This was an analysis of data from the PAN‐COVID registry (1 January to 25 July 2020), which includes pregnancies with suspected or confirmed maternal SARS‐CoV‐2 infection at any stage in pregnancy, and the AAP‐SONPM National Perinatal COVID‐19 registry (4 April to 8 August 2020), which includes pregnancies with positive maternal testing for SARS‐CoV‐2 from 14 days before delivery to 3 days after delivery. The registries collected data on maternal, fetal, perinatal and neonatal outcomes. The PAN‐COVID results are presented overall for pregnancies with suspected or confirmed SARS‐CoV‐2 infection and separately in those with confirmed infection. Results We report on 4005 pregnant women with suspected or confirmed SARS‐CoV‐2 infection (1606 from PAN‐COVID and 2399 from AAP‐SONPM). For obstetric outcomes, in PAN‐COVID overall and in those with confirmed infection in PAN‐COVID and AAP‐SONPM, respectively, maternal death occurred in 0.5%, 0.5% and 0.2% of cases, early neonatal death in 0.2%, 0.3% and 0.3% of cases and stillbirth in 0.5%, 0.6% and 0.4% of cases. Delivery was preterm (< 37 weeks' gestation) in 12.0% of all women in PAN‐COVID, in 16.1% of those women with confirmed infection in PAN‐COVID and in 15.7% of women in AAP‐SONPM. Extreme preterm delivery (< 27 weeks' gestation) occurred in 0.5% of cases in PAN‐COVID and 0.3% in AAP‐SONPM. Neonatal SARS‐CoV‐2 infection was reported in 0.9% of all deliveries in PAN‐COVID overall, in 2.0% in those with confirmed infection in PAN‐COVID and in 1.8% in AAP‐SONPM; the proportions of neonates tested were 9.5%, 20.7% and 87.2%, respectively. The rates of a small‐for‐gestational‐age (SGA) neonate were 8.2% in PAN‐COVID overall, 9.7% in those with confirmed infection and 9.6% in AAP‐SONPM. Mean gestational‐age‐adjusted birth‐weight Z‐scores were −0.03 in PAN‐COVID and −0.18 in AAP‐SONPM. Conclusions The findings from the UK and USA registries of pregnancies with SARS‐CoV‐2 infection were remarkably concordant. Preterm delivery affected a higher proportion of women than expected based on historical and contemporaneous national data. The proportions of pregnancies affected by stillbirth, a SGA infant or early neonatal death were comparable to those in historical and contemporaneous UK and USA data. Although maternal death was uncommon, the rate was higher than expected based on UK and USA population data, which is likely explained by underascertainment of women affected by milder or asymptomatic infection in pregnancy in the PAN‐COVID study, although not in the AAP‐SONPM study. The data presented support strong guidance for enhanced precautions to prevent SARS‐CoV‐2 infection in pregnancy, particularly in the context of increased risks of preterm delivery and maternal mortality, and for priority vaccination of pregnant women and women planning pregnancy. Copyright © 2021 ISUOG. Published by John Wiley & Sons Ltd

Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms

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