2,098 research outputs found

    Meta‐analysis of oral antibiotics, in combination with preoperative intravenous antibiotics and mechanical bowel preparation the day before surgery, compared with intravenous antibiotics and mechanical bowel preparation alone to reduce surgical‐site infections in elective colorectal surgery

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    Background: Surgical‐site infection (SSI) is a potentially serious complication following colorectal surgery. The present systematic review and meta‐analysis aimed to investigate the effect of preoperative oral antibiotics and mechanical bowel preparation (MBP) on SSI rates. Methods: A systematic review of PubMed, Cochrane Database of Systematic Reviews and Cochrane Central Register of Controlled Trials was performed using appropriate keywords. Included were RCTs and observational studies reporting rates of SSI following elective colorectal surgery, in patients given preoperative oral antibiotic prophylaxis, in combination with intravenous (i.v.) antibiotic prophylaxis and MBP, compared with patients given only i.v. antibiotic prophylaxis with MBP. A meta‐analysis was undertaken. Results: Twenty‐two studies (57 207 patients) were included, of which 14 were RCTs and eight observational studies. Preoperative oral antibiotics, in combination with i.v. antibiotics and MBP, were associated with significantly lower rates of SSI than combined i.v. antibiotics and MBP in RCTs (odds ratio (OR) 0·45, 95 per cent c.i. 0·34 to 0·59; P < 0·001) and cohort studies (OR 0·47, 0·44 to 0·50; P < 0·001). There was a similarly significant effect on SSI with use of a combination of preoperative oral aminoglycoside and erythromycin (OR 0·40, 0·25 to 0·64; P < 0·001), or preoperative oral aminoglycoside and metronidazole (OR 0·51, 0·39 to 0·68; P < 0·001). Preoperative oral antibiotics were significantly associated with reduced postoperative rates of anastomotic leak, ileus, reoperation, readmission and mortality in the cohort studies. Conclusion: Oral antibiotic prophylaxis, in combination with MBP and i.v. antibiotics, is superior to MBP and i.v. antibiotic prophylaxis alone in reducing SSI in elective colorectal surgery

    Providing parents with support on fractions through use of a Podcast

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    Research has shown that positive effect parental engagement has with children’s academic achievement. The main aim of this study was to create a resource (Appendices 1 and 2) which would enable parents to help their children with mathematics. It is based on the teaching of fractions at KS3, a topic which literature has shown to be very problematic for both children and adults. The research questions considered in this project were to measure the effectiveness of a podcast for teaching fractions to parents and to explore if parents would use this resource to help their children. The podcast lasting approximately 8-10 minutes guides busy parents through a step to step guide of fraction equivalence whilst incorporating some activities so that parent can test their knowledge. The feedback received from parents was very positive with all parents agreeing that the use of podcasts was an enjoyable, interactive method of learning which would provide them with more confidence when helping their children with Mathematics

    On an Additive Characterization of a Skew Hadamard (n, n−1/ 2 , n−3 4 )-Difference Set in an Abelian Group

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    We give a combinatorial proof of an additive characterization of a skew Hadamard (n, n−1 2 , n−3 4 )-difference set in an abelian group G. This research was motivated by the p = 4k + 3 case of Theorem 2.2 of Monico and Elia [4] concerning an additive characterization of quadratic residues in Z p. We then use the known classification of skew (n, n−1 2 , n−3 4 )-difference sets in Z n to give a result for integers n = 4k +3 that strengthens and provides an alternative proof of the p = 4k + 3 case of Theorem 2.2 of [4]

    Nutsedge protects root-knot nematodes from soil fumigation

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    Helminths in the hygiene hypothesis:Sooner or later?

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    There is increasing recognition that exposures to infectious agents evoke fundamental effects on the development and behaviour of the immune system. Moreover, where infections (especially parasitic infections) have declined, immune responses appear to be increasingly prone to hyperactivity. For example, epidemiological studies of parasite-endemic areas indicate that prenatal or early-life experience of infections can imprint an individual's immunological reactivity. However, the ability of helminths to dampen pathology in established inflammatory diseases implies that they can have therapeutic effects even if the immune system has developed in a low-infection setting. With recent investigations of how parasites are able to modulate host immune pathology at the level of individual parasite molecules and host cell populations, we are now able to dissect the nature of the host–parasite interaction at both the initiation and recall phases of the immune response. Thus the question remains – is the influence of parasites on immunity one that acts primarily in early life, and at initiation of the immune response, or in adulthood and when recall responses occur? In short, parasite immunosuppression – sooner or later
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