13 research outputs found
United States Business Immigration Manual
Get PDF[Excerpt] This Manual provides a general overview of: (i) the types of U.S. visas most commonly used by employers; (ii) methods for obtaining permanent residence through employer sponsorship; and (iii) important employer responsibilities under U.S. immigration law. This Manual is not intended to be exhaustive, as U.S. immigration laws and policies are constantly changing. As we go to press, the content of this publication is accurate
Under International Law, what Conventions or customary international law best address modern acts of piracy?
Get PDFProvide a comparative analysis of the proposed United Nations Extraterritorial Piracy Court and the Lockerbie Tribunal
Get PDFHow can a program similar to Rewards for Justice be established that offers rewards for information related to the financiers or key leaders of pirate organizations?
Get PDFCan States exercise universal jurisdiction over non-national pirates captured on the high seas?
Get PDFUnder international standards of justice, can audio or video recordings of distress calls and footage from vessels allegedly subjected to piratical attacks be admitted into evidence? How would authenticity be proved? Does this deny the opportunity to cross-examine?
Get PDFWhat domestic and international legal efforts can best ensure the freezing of assets and money acquired through acts of piracy?
Get PDFCan piracy be considered a crime against humanity for purposes of the jurisdiction of the International Criminal Court?
Get PDFIf piracy suspects are seriously mistreated by the capturing authorities before being handed over to a third State or an international tribunal for trial, would international standards of justice require that the case be dismissed?
Get PDFBioactivation of Trimethoprim to Protein-Reactive Metabolites in Human Liver Microsomes
Get PDFABSTRACT The formation of drug-protein adducts via metabolic activation and covalent binding may stimulate an immune response or may result in direct cell toxicity. Protein covalent binding is a potentially pivotal step in the development of idiosyncratic adverse drug reactions (IADRs). Trimethoprim (TMP)-sulfamethoxazole (SMX) is a combination antibiotic that commonly causes IADRs. Recent data suggest that the contribution of the TMP component of TMP-SMX to IADRs may be underappreciated. We previously demonstrated that TMP is bioactivated to chemically reactive intermediates that can be trapped in vitro by N-acetyl cysteine (NAC), and we have detected TMP-NAC adducts (i.e., mercapturic acids) in the urine of patients taking TMP-SMX. However, the occurrence and extent of TMP covalent binding to proteins was unknown
