Observations from the EEFIT-TDMRC mission to Banda Aceh, Indonesia to investigate the recovery from the 2004 Indian Ocean Tsunami

On 26th December 2004 a subduction zone earthquake of magnitude Mw 9.3 struck off the coast of Sumatra in Indonesia. A large area of the Indian Ocean seabed was vertically displaced, and as a result a tsunami wave was generated that went on to affect many countries around the world. One of the worst hit places was the Aceh province of Sumatra where the capital city, Banda Aceh, experienced serious ground shaking and significant sea water inundation. In Indonesia at least 126,732 people were killed, a further 93,652 people were confirmed missing and 533,770 people were displaced. In 2022, nearly 20 years on from the disaster, engineers and scientists from the UK Earthquake Engineering Field Investigation Team (EEFIT) and from the Indonesian Tsunami and Disaster Mitigation Research Centre (TDMRC) conducted a joint longterm recovery mission. This paper reflects on how a society rebuilds after such a devastating loss and what lessons can be learnt as a community for future disaster risk reduction. The scope of the paper includes the rapid assessment of post-disaster housing, community infrastructure and preparedness measures

Fellow travellers: a concordance of colonization patterns between mice and men in the North Atlantic region

<p>Abstract</p> <p>Background</p> <p>House mice (<it>Mus musculus</it>) are commensals of humans and therefore their phylogeography can reflect human colonization and settlement patterns. Previous studies have linked the distribution of house mouse mitochondrial (mt) DNA clades to areas formerly occupied by the Norwegian Vikings in Norway and the British Isles. Norwegian Viking activity also extended further westwards in the North Atlantic with the settlement of Iceland, short-lived colonies in Greenland and a fleeting colony in Newfoundland in 1000 AD. Here we investigate whether house mouse mtDNA sequences reflect human history in these other regions as well.</p> <p>Results</p> <p>House mice samples from Iceland, whether from archaeological Viking Age material or from modern-day specimens, had an identical mtDNA haplotype to the clade previously linked with Norwegian Vikings. From mtDNA and microsatellite data, the modern-day Icelandic mice also share the low genetic diversity shown by their human hosts on Iceland. Viking Age mice from Greenland had an mtDNA haplotype deriving from the Icelandic haplotype, but the modern-day Greenlandic mice belong to an entirely different mtDNA clade. We found no genetic association between modern Newfoundland mice and the Icelandic/ancient Greenlandic mice (no ancient Newfoundland mice were available). The modern day Icelandic and Newfoundland mice belong to the subspecies <it>M. m. domesticus</it>, the Greenlandic mice to <it>M. m. musculus</it>.</p> <p>Conclusions</p> <p>In the North Atlantic region, human settlement history over a thousand years is reflected remarkably by the mtDNA phylogeny of house mice. In Iceland, the mtDNA data show the arrival and continuity of the house mouse population to the present day, while in Greenland the data suggest the arrival, subsequent extinction and recolonization of house mice - in both places mirroring the history of the European human host populations. If house mice arrived in Newfoundland with the Viking settlers at all, then, like the humans, their presence was also fleeting and left no genetic trace. The continuity of mtDNA haplotype in Iceland over 1000 years illustrates that mtDNA can retain the signature of the ancestral house mouse founders. We also show that, in terms of genetic variability, house mouse populations may also track their host human populations.</p

The combination of vemurafenib and cobimetinib in advanced melanoma

Introduction: Advanced melanoma with a BRAF V600 mutation responds to treatment with BRAF inhibitors such as vemurafenib, with great improvement in tumour response and patient survival. Despite early and often dramatic responses, resistance to vemurafenib develops. Concurrent inhibition of a downstream protein, MEK, also involved in the MAPK oncogenic signalling pathway, defers development of resistance. The MEK inhibitor cobimetinib has been successfully and safely combined with vemurafenib, further improving response rate and survival when compared to vemurafenib monotherapy.Areas covered: This article covers the mechanism of action of both vemurafenib and cobimetinib, in addition to describing results from the key Phase I and Phase III studies which led to registration of the combination in the US and Europe as a therapeutic option for advanced BRAF mutant melanoma. The safety profile of these agents is also discussed in detail, including similarities with and differences from the competitor compounds dabrafenib and trametinib.Expert opinion: Vemurafenib in combination with cobimetinib provides an alternative BRAF/MEK blockade. The combination is tolerable, safe and effective and results in fewer skin toxicities than vemurafenib monotherapy

Multi-Agent System (MAS) Applications in Ambient Intelligence (AmI) Environments

Proceedings of: 8th Conference on Practical Applications of Agents and Multi-Agent Systems (PAAMS`10). Salamanca (Spain), 28-30 April 2010Research in context-aware systems has been moving towards reusable and adaptable architectures for managing more advanced human-computer interfaces. Ambient. Intelligence (AmI) investigates computer-based services, which are ubiquitous and based on a variety of objects and devices. Their intelligent and intuitive interfaces act as mediators through which people can interact with the ambient environment. In this paper we present an agent-based architecture which supports the execution of agents in AmI environments. Two case studies are also presented, an airport information system and a railway information system, which uses spoken conversational agents to respond to the user's requests using the contextual information that includes the location information of the user.This work has been partially supported by CICYT TIN2008-06742-C02-02/TSI, CICYT TEC2008-06732-C02-02/TEC, SINPROB, CAM MADRINET S-0505/TIC/0255 and DPS2008-07029-C02-02Publicad

Composite nucleons in scalar and vector mean-fields

We emphasize that the composite structure of the nucleon may play quite an important role in nuclear physics. It is shown that the momentum-dependent repulsive force of second order in the scalar field, which plays an important role in Dirac phenomenology, can be found in the quark-meson coupling (QMC) model, and that the properties of nuclear matter are well described through the quark-scalar density in a nucleon and a self-consistency condition for the scalar field. The difference between theories of point-like nucleons and composite ones may be seen in the change of the $\omega$-meson mass in nuclear matter if the composite nature of the nucleon suppresses contributions from nucleon-antinucleon pair creation.Comment: 10 page

Cathelicidin suppresses lipid accumulation and hepatic steatosis by inhibition of the CD36 receptor.

Background and objectivesObesity is a global epidemic which increases the risk of the metabolic syndrome. Cathelicidin (LL-37 and mCRAMP) is an antimicrobial peptide with an unknown role in obesity. We hypothesize that cathelicidin expression correlates with obesity and modulates fat mass and hepatic steatosis.Materials and methodsMale C57BL/6 J mice were fed a high-fat diet. Streptozotocin was injected into mice to induce diabetes. Experimental groups were injected with cathelicidin and CD36 overexpressing lentiviruses. Human mesenteric fat adipocytes, mouse 3T3-L1 differentiated adipocytes and human HepG2 hepatocytes were used in the in vitro experiments. Cathelicidin levels in non-diabetic, prediabetic and type II diabetic patients were measured by enzyme-linked immunosorbent assay.ResultsLentiviral cathelicidin overexpression reduced hepatic steatosis and decreased the fat mass of high-fat diet-treated diabetic mice. Cathelicidin overexpression reduced mesenteric fat and hepatic fatty acid translocase (CD36) expression that was reversed by lentiviral CD36 overexpression. Exposure of adipocytes and hepatocytes to cathelicidin significantly inhibited CD36 expression and reduced lipid accumulation. Serum cathelicidin protein levels were significantly increased in non-diabetic and prediabetic patients with obesity, compared with non-diabetic patients with normal body mass index (BMI) values. Prediabetic patients had lower serum cathelicidin protein levels than non-diabetic subjects.ConclusionsCathelicidin inhibits the CD36 fat receptor and lipid accumulation in adipocytes and hepatocytes, leading to a reduction of fat mass and hepatic steatosis in vivo. Circulating cathelicidin levels are associated with increased BMI. Our results demonstrate that cathelicidin modulates the development of obesity

Bioarchaeological and Climatological Evidence for the Fate of Norse Farmers in Medieval Greenland

Greenland, far north land of the Atlantic, has often been beyond the limit of European farming settlement. One of its Norse settlements, colonized just before AD 1000, is — astonishingly — not even at the southern tip, but a way up the west coast, the \u27Western Settlement\u27. Environmental studies show why its occupation came to an end within five centuries, leaving Greenland once more a place of Arctic-adapted hunters

Hybrid stars with the color dielectric and the MIT bag models

We study the hadron-quark phase transition in the interior of neutron stars (NS). For the hadronic sector, we use a microscopic equation of state (EOS) involving nucleons and hyperons derived within the Brueckner-Bethe-Goldstone many-body theory, with realistic two-body and three-body forces. For the description of quark matter, we employ both the MIT bag model with a density dependent bag constant, and the color dielectric model. We calculate the structure of NS interiors with the EOS comprising both phases, and we find that the NS maximum masses are never larger than 1.7 solar masses, no matter the model chosen for describing the pure quark phase.Comment: 11 pages, 5 figures, submitted to Phys. Rev.

Mean difference in live-weight per incremental difference in body condition score estimated in multiple sheep breeds and crossbreds

peer-reviewedBody condition score (BCS) is a subjective assessment of the proportion of body fat an animal possesses and is independent of frame size. There is a growing awareness of the importance of mature animal live-weight given its contribution to the overall costs of production of a sector. Because of the known relationship between BCS and live-weight, strategies to reduce live-weight could contribute to the favouring of animals with lesser body condition. The objective of the present study was to estimate the average difference in live-weight per incremental change in BCS, measured subjectively on a scale of 1 to 5. The data used consisted of 19 033 BCS and live-weight observations recorded on the same day from 7556 ewes on commercial and research flocks; the breeds represented included purebred Belclare (540 ewes), Charollais (1484 ewes), Suffolk (885 ewes), Texel (1695 ewes), Vendeen (140 ewes), as well as, crossbreds (2812 ewes). All associations were quantified using linear mixed models with the dependent variable of live-weight; ewe parity was included as a random effect. The independent variables were BCS, breed (n=6), stage of the inter-lambing interval (n=6; pregnancy, lambing, pre-weaning, at weaning, post-weaning and mating) and parity (1, 2, 3, 4 and 5+). In addition, two-way interactions were used to investigate whether the association between BCS and live-weight differed by parity, a period of the inter-lambing interval or breed. The association between BCS and live-weight differed by parity, by a period of the inter-lambing interval and by breed. Across all data, a one-unit difference in BCS was associated with 4.82 (SE=0.08) kg live-weight, but this differed by parity from 4.23 kg in parity 1 ewes to 5.82 kg in parity 5+ ewes. The correlation between BCS and live-weight across all data was 0.48 (0.47 when adjusted for nuisance factors in the statistical model), but this varied from 0.48 to 0.53 by parity, from 0.36 to 0.63 by stage of the inter-lambing interval and from 0.41 to 0.62 by breed. Results demonstrate that consideration should be taken of differences in BCS when comparing ewes on live-weight as differences in BCS contribute quite substantially to differences in live-weight; moreover, adjustments for differences in BCS should consider the population stratum, especially breed