Rank Corpuscles : Soil and Identity in Eighteenth-Century Representations

In this dissertation, I analyze scenes of encounter between human beings and human dust in eighteenth-century texts. Ploughmen exhume bones and armor in the arable, consumers taste other people’s excrement in their vegetables, and improvers lime the earth to break down ancient corpses. In process, I find that eighteenth-century British authors recognized the soil as an agent of continuity, with the capacity to preserve, mobilize, and disseminate the material constituents of identity from one body into another. At times, the soil’s powerful co-operative agency is threatening to the integrity of the human self, but I argue that authors negotiate between the threat posed by dirt’s unknowing agency, and the opportunities that such a mediator affords for bridging the aporia wrought by death, partition, and forgetfulness. Exploring agricultural treatises, sermons and natural philosophy as well as georgic poetry, Restoration drama, novels and travelogues, this dissertation engages with new-materialist perspectives on literary history, arguing that eighteenth-century authors saw in soil not just a symbol for regeneration or fragmentation, but a material agent in the production of identity. At the same time, it offers historically focused readings of each text, showing how authors rely on the agency of soil to resolve particular challenges to continuity

The Effects of a Nesprin-2-Giant Mutant on Nuclear Positioning and the Pathogenesis of Emery-Dreifuss Muscular Dystrophy

Faculty advisor: G. W. Grant LuxtonThis research was supported by the Undergraduate Research Opportunities Program (UROP)

Structure-Function Analysis of Lamina-Associated Polypeptide 1 and its Role in the Activation of the AAA+ ATPase, TorsinA

This research was supported by the Undergraduate Research Opportunities Program (UROP).McQuown, Alexander. (2015). Structure-Function Analysis of Lamina-Associated Polypeptide 1 and its Role in the Activation of the AAA+ ATPase, TorsinA. Retrieved from the University Digital Conservancy, https://hdl.handle.net/11299/172629

Integrated human-machine interface for closed-loop stimulation using implanted and wearable devices

Recent development in implantable devices for electrical brain stimulation includes sensing and embedded computing capabilities that enable adaptive stimulation strategies. Applications include stimulation triggered by pathologic brain activity and endogenous rhythms, such as circadian rhythms. We developed and tested a system that integrates an electrical brain stimulation & sensing implantable device with embedded computing and uses a distributed system with commercial electronics, smartphone and smartwatch for patient annotations, extensive behavioral testing, and adaptive stimulation in subjects in their natural environments. The system enables precise time synchronization of the external components with the brain stimulating device and is coupled with automated analysis of continuous streaming electrophysiology synchronized with patient reports. The system leverages a real-time bi-directional interface between devices and patients with epilepsy living in their natural environment

Phosphodiesterase 1b (PDE1B) Regulates Spatial and Contextual Memory in Hippocampus

Augmentation of cyclic nucleotide signaling through inhibition of phosphodiesterase (PDE) activity has long been understood to enhance memory. Efforts in this domain have focused predominantly on PDE4, a cAMP-specific phosphodiesterase implicated in consolidation. But less is known about the function of other PDEs expressed in neuroanatomical regions critical to memory. The PDE1 isoforms are the only PDEs to regulate neuronal cAMP and cGMP levels in a Ca2+/Calmodulin (CaM) dependent manner. Here, we show that knock-down of PDE1B in hippocampus of adult mice enhances contextual and spatial memory without effect on non-cognitive behaviors. Pharmacological augmentation of memory in rats was observed with a selective inhibitor of PDE1 dosed before and immediately after training, but not with drug dosed either 1 h after training or before recall. Our data clearly demonstrate a role for the PDE1B isoforms as negative regulators of memory, and they implicate PDE1 in an early phase of consolidation, but not retrieval. Inhibition of PDE1B is a promising therapeutic mechanism for treating memory impairment

Creation and Implementation of a Large-Scale Geriatric Interprofessional Education Experience

The care of the older adult requires an interprofessional approach to solve complex medical and social problems, but this approach is difficult to teach in our educational silos. We developed an interprofessional educational session in response to national requests for innovative practice models that use collaborative interprofessional teams. We chose geriatric fall prevention as our area of focus as our development of the educational session coincided with the development of an interprofessional Fall Risk Reduction Clinic. Our aim of this study was to evaluate the number and type of students who attended a pilot and 10 subsequent educational sessions. We also documented the changes that occurred due to a Plan-Do-Study-Act (PDSA) rapid-cycle improvement model to modify our educational session. The educational session evolved into an online presession self-study didactic and in-person educational session with a poster/skill section, an interprofessional team simulation, and simulated patient experience. The simulated patient experience included an interprofessional fall evaluation, team meeting, and presentation to an expert panel. The pilot session had 83 students from the three sponsoring institutions (hospital system, university, and medical university). Students were from undergraduate nursing, nurse practitioner graduate program, pharmacy, medicine, social work, physical therapy, nutrition, and pastoral care. Since the pilot, 719 students have participated in various manifestations of the online didactic plus in-person training sessions. Ten separate educational sessions have been given at three different institutions. Survey data with demographic information were available on 524 participants. Students came from ten different schools and represented thirteen different health care disciplines. A large-scale interprofessional educational session is possible with rapid-cycle improvement, inclusion of educators from a variety of learning institutions, and flexibility with curriculum to accommodate learners in various stages of training