A case study of mission-oriented innovation in Greater Manchester

This paper analyses the innovative approach taken by Greater Manchester Combined Authority (GMCA) to solve the challenge of carbon emissions within the city

deFuse: An Algorithm for Gene Fusion Discovery in Tumor RNA-Seq Data

Gene fusions created by somatic genomic rearrangements are known to play an important role in the onset and development of some cancers, such as lymphomas and sarcomas. RNA-Seq (whole transcriptome shotgun sequencing) is proving to be a useful tool for the discovery of novel gene fusions in cancer transcriptomes. However, algorithmic methods for the discovery of gene fusions using RNA-Seq data remain underdeveloped. We have developed deFuse, a novel computational method for fusion discovery in tumor RNA-Seq data. Unlike existing methods that use only unique best-hit alignments and consider only fusion boundaries at the ends of known exons, deFuse considers all alignments and all possible locations for fusion boundaries. As a result, deFuse is able to identify fusion sequences with demonstrably better sensitivity than previous approaches. To increase the specificity of our approach, we curated a list of 60 true positive and 61 true negative fusion sequences (as confirmed by RT-PCR), and have trained an adaboost classifier on 11 novel features of the sequence data. The resulting classifier has an estimated value of 0.91 for the area under the ROC curve. We have used deFuse to discover gene fusions in 40 ovarian tumor samples, one ovarian cancer cell line, and three sarcoma samples. We report herein the first gene fusions discovered in ovarian cancer. We conclude that gene fusions are not infrequent events in ovarian cancer and that these events have the potential to substantially alter the expression patterns of the genes involved; gene fusions should therefore be considered in efforts to comprehensively characterize the mutational profiles of ovarian cancer transcriptomes

Financing for climate action

This policy brief summarises some of the recent research produced by thought leaders and researchers at UCL’s Institute for Innovation and Public Purpose (IIPP) exploring key questions around climate-aligned finance and sustainable growth. These include the pricing and financial risks related to the loss of nature and biodiversity; the importance of heterogeneous investors; scale economies and the commercialisation of innovative renewable energy technologies; and the role of central banks and public wealth funds in enabling a more rapid transition to a green economy

Bridge House Restoration

Bridge House was severely neglected for years since its creation. Our team’s primary objective was to rejuvenate the structure and once again make it a priority destination for the public when visiting the Experimental Structures Laboratory. With this goal in mind, we replaced the plywood barricades with guard railings designed and fabricated by the team to complement those installed on the structure by the previous group. With the elimination of the plywood barricades, the Bridge House could once again be a sense of pride in the rich historical landscape of our Cal Poly community. In addition, our team hoped to gain more knowledge and experience in working in an interdisciplinary group. An important goal for us was to have an experience that mimicked a true construction project. Throughout the experience, we expected collaboration between each discipline from the pre-construction phase through the final closeout of the structure. We aimed to embrace the Cal Poly spirit of learn by doing, by designing, welding and installing the guardrails around the structure by hand. At the end of this project, we hoped the team would gain experience in the collaboration of design, scheduling, budgeting, welding and manufacturing

Segregation of Mn, Si, Al, and oxygen during the friction stir welding of DH36 steel

This work investigates the role of welding speed in elemental segregation of Mn, Si, Al, and oxygen during friction stir welding (FSW) in DH36 steel. The experimental work undertaken showed that when the speed of the FSW process exceeds 500 RPM with a traverse speed of 400 mm/min, then elemental segregation of Mn, Si, Al, and O occurred. The mechanism of this segregation is not fully understood; additionally, the presence of oxygen within these segregated elements needs investigation. This work examines the elemental segregation within DH36 steel by conducting heat treatment experiments on unwelded samples incrementally in the range of 1200–1500 °C and at cooling rates similar to that in FSW process. The results of heat treatments were compared with samples welded under two extremes of weld tool speeds, namely W1 low tool speeds (200 RPM with traverse speed of 100 mm/min) and W2 high tool speeds (550 RPM with traverse speed of 400 mm/min). The results from the heat treatment trials showed that segregation commences when the temperature exceeds 1400 °C and Mn, Si, Al, and oxygen segregation progress occurs at 1450 °C and at a cooling rate associated with acicular ferrite formation. It was also found that high rotational speeds exceeding 500 RPM caused localized melting at the advancing-trailing side of the friction stir-welded samples. The study aims to estimate peak temperature limits at which elemental segregation does not occur and hence prevent their occurrence in practice by applying the findings to the tool’s rotational and traverse speed that correspond to the defined temperature

Verification and Validation of NASA-Supported Enhancements to the Near Real Time Harmful Algal Blooms Observing System (HABSOS)

This report discusses verification and validation (V&V) assessment of Moderate Resolution Imaging Spectroradiometer (MODIS) ocean data products contributed by the Naval Research Laboratory (NRL) and Applied Coherent Technologies (ACT) Corporation to National Oceanic Atmospheric Administration s (NOAA) Near Real Time (NRT) Harmful Algal Blooms Observing System (HABSOS). HABSOS is a maturing decision support tool (DST) used by NOAA and its partners involved with coastal and public health management

UReCA, the NCHC Web journal of Undergraduate Research and Creative Activity

Our vision is an academic community without borders, a connected network of aspirational students committed to the advancement of knowledge and appreciation of the arts. UReCA fosters the exchange of intellectual and creative work between undergraduate students, providing a platform where students can engage with and contribute to the advancement of their individual fields. UReCA was first conceived by Johnny MacLean (Southern Utah University) and Brian White (Graceland University) at an annual NCHC conference in Phoenix, Arizona. MacLean and White noticed that while several academic outlets existed for honors faculty and administrators, there was an absence of student-focused publications within the NCHC community. Inspired by the experiential education model used by Partners in the Parks, Johnny and Brian saw another opportunity for honors students to engage in experiential learning. Their vision: an international undergraduate journal, peer reviewed and produced for the web by an interdisciplinary community of honors students