Impact of GRM: New evidence from the Soviet Union

Gravity information released by the Soviet Union allows the quantitative assessment of how the geopotential research mission (GRM) mission might effect the ability to use global gravity data for continental tectonic interpretation. The information is of an isostatic response spectra for eight individual tectonic units in the USSR. The regions examined include the Caroathians, Caucasus, Urals, Pamirs, Tien-Shan, Altal, Chersky Ridge, and East Siberian Platform. The 1 deg x 1 deg gravity data are used to calculate the admittances are used in two different sorts of tectonic studies of mountain belts in the USSR: (1) interpretation of isostatic responses in terms of plate models of compensation for mountainous terrain. Using geologic information concerning time of the orogeny, lithospheric plates involved, and polarity of subduction in collision zones, they convert the best-fitting flexural rigidity to an elastic plate thickness for the lithospheric plate inferred to underlie the mountains; the isostatic admittance functions is an attempt to directly model gravity and topography data for a few select regions in the Soviet Union. By knowing the value of the expected correlation between topography and gravity from the admittances, the Artemjev's map in mountainous areas can be calibrated, and the maps are converted back to Bouguer gravity. This procedure is applied to the Caucasus and southern Urals

Do Androids Dream of Bad TV?: Un/originality in Neil Burger’s Voyagers

Critics did not take kindly to Neil Burger’s Voyager (2021). On Rotten Tomatoes, the film scored a dismal 25%, and the consensus is that it’s a trip best not taken: “It has a game cast and a premise ripe with potential, but Voyagers drifts in familiar orbit rather than fully exploring its intriguing themes.” This article seeks neither to reclaim the film as an unjustly neglected cinematic masterpiece nor to assert its importance in the canon of dystopian works. Rather, it treats Voyagers as a test case for exploring our own critical investment in the genre. Our aims are twofold. First, we argue that the film speaks to the dystopian genre’s fundamental distrust of future generations to make the best decisions. It effectively exposes the central irony that we presume to know best though we had signally failed to do right by our planet in the first place. Secondly, we reveal how unoriginal work can still point to new ways forward. By the end of the film, the Humanitas mission is back on course, following Zac’s (Fionn Whitehead) demise. Sela (Lily-Rose Depp) is surely right to wonder, to Christopher (Tye Sheridan), how they should ensure that mutiny doesn’t recur. The short answer? They can’t—and they probably shouldn’t. The capacity for events, like those we witness in Voyagers, to recur—and many times over too—is at least partially responsible for the dystopian genre’s appeal and it contributes to the genre’s persistent ethical ruminations. This essay advances scholarship by suggesting that even the most derivative of cinema can offer profound insights into our world, in this case, how democracies work

Structural Insights into Rational Design of Single-Domain Antibody-Based Antitoxins against Botulinum Neurotoxins.

Botulinum neurotoxin (BoNT) is one of the most acutely lethal toxins known to humans, and effective treatment for BoNT intoxication is urgently needed. Single-domain antibodies (VHH) have been examined as a countermeasure for BoNT because of their high stability and ease of production. Here, we investigate the structures and the neutralization mechanisms for six unique VHHs targeting BoNT/A1 or BoNT/B1. These studies reveal diverse neutralizing mechanisms by which VHHs prevent host receptor binding or block transmembrane delivery of the BoNT protease domain. Guided by this knowledge, we design heterodimeric VHHs by connecting two neutralizing VHHs via a flexible spacer so they can bind simultaneously to the toxin. These bifunctional VHHs display much greater potency in a mouse co-intoxication model than similar heterodimers unable to bind simultaneously. Taken together, our studies offer insight into antibody neutralization of BoNTs and advance our ability to design multivalent anti-pathogen VHHs with improved therapeutic properties

Suite of simple metrics reveals common movement syndromes across vertebrate taxa

ecause empirical studies of animal movement are most-often site- and species-specific, we lack understanding of the level of consistency in movement patterns across diverse taxa, as well as a framework for quantitatively classifying movement patterns. We aim to address this gap by determining the extent to which statistical signatures of animal movement patterns recur across ecological systems. We assessed a suite of movement metrics derived from GPS trajectories of thirteen marine and terrestrial vertebrate species spanning three taxonomic classes, orders of magnitude in body size, and modes of movement (swimming, flying, walking). Using these metrics, we performed a principal components analysis and cluster analysis to determine if individuals organized into statistically distinct clusters. Finally, to identify and interpret commonalities within clusters, we compared them to computer-simulated idealized movement syndromes representing suites of correlated movement traits observed across taxa (migration, nomadism, territoriality, and central place foraging)

How Do Data Analysts Respond to AI Assistance? A Wizard-of-Oz Study

Data analysis is challenging as analysts must navigate nuanced decisions that may yield divergent conclusions. AI assistants have the potential to support analysts in planning their analyses, enabling more robust decision making. Though AI-based assistants that target code execution (e.g., Github Copilot) have received significant attention, limited research addresses assistance for both analysis execution and planning. In this work, we characterize helpful planning suggestions and their impacts on analysts' workflows. We first review the analysis planning literature and crowd-sourced analysis studies to categorize suggestion content. We then conduct a Wizard-of-Oz study (n=13) to observe analysts' preferences and reactions to planning assistance in a realistic scenario. Our findings highlight subtleties in contextual factors that impact suggestion helpfulness, emphasizing design implications for supporting different abstractions of assistance, forms of initiative, increased engagement, and alignment of goals between analysts and assistants.Comment: Accepted to CHI 202

Damage Analysis Modified TRAC Computer Program (DAMTRAC)

A computer program tailored for EMP damage analysis of solid-state circuitry has been developed by modifying the existing TRAC network analysis program. Modification of the TRAC diode and transistor models to include breakdown parameters and the addition of a semiconductor device parameter library have greatly simplified the analyst\u27s task. An added feature is a subroutine that automatically calculates the amplitude and duration of transient power dissipated in electronic circuit components