The Roots, Practices and Consequences of Terrorism: A Literature Review of Research in the Arts & Humanities

This report contains a literature review of Arts and Humanities research on the roots, practices and consequences of terrorism with an annotated bibliography. The literature review was carried out for the Home Office by a team at the University of Leeds between March and October 2006

Eliminating ambiguities for quantum corrections to strings moving in AdS4×CP3AdS_4\times \mathbb{CP}^3

We apply a physical principle, previously used to eliminate ambiguities in quantum corrections to the 2 dimensional kink, to the case of spinning strings moving in $AdS_4\times \mathbb{CP}^3$, thought of as another kind of two dimensional soliton. We find that this eliminates the ambiguities and selects the result compatible with AdS/CFT, providing a solid foundation for one of the previous calculations, which found agreement. The method can be applied to other classical string "solitons".Comment: 18 pages, latex; references added, comments added at end of section 4, a few words changed; footnote added on page 1

Cancelled operations: a 7-day cohort study of planned adult inpatient surgery in 245 UK National Health Service hospitals.

BACKGROUND: Cancellation of planned surgery impacts substantially on patients and health systems. This study describes the incidence and reasons for cancellation of inpatient surgery in the UK NHS. METHODS: We conducted a prospective observational cohort study over 7 consecutive days in March 2017 in 245 NHS hospitals. Occurrences and reasons for previous surgical cancellations were recorded. Using multilevel logistic regression, we identified patient- and hospital-level factors associated with cancellation due to inadequate bed capacity. RESULTS: We analysed data from 14 936 patients undergoing planned surgery. A total of 1499 patients (10.0%) reported previous cancellation for the same procedure; contemporaneous hospital census data indicated that 13.9% patients attending inpatient operations were cancelled on the day of surgery. Non-clinical reasons, predominantly inadequate bed capacity, accounted for a large proportion of previous cancellations. Independent risk factors for cancellation due to inadequate bed capacity included requirement for postoperative critical care [odds ratio (OR)=2.92; 95% confidence interval (CI), 2.12-4.02; P CONCLUSIONS: A significant proportion of patients presenting for surgery have experienced a previous cancellation for the same procedure. Cancer surgery is relatively protected, but bed capacity, including postoperative critical care requirements, are significant risk factors for previous cancellations

A critique of narrative reviews of the evidence-base for ECT in depression

© The Author(s), 2022. Published by Cambridge University Press. This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/)There has been recent debate regarding the efficacy of electroconvulsive therapy in the treatment of depression. This has been based on narrative reviews that contradict existing systematic reviews and meta-analyses. In this special article, we highlight the mistakes that occur when interpreting evidence using narrative reviews, as opposed to conventional systematic reviews and meta-analyses.Peer reviewedFinal Published versio

Light-cone gauge Hamiltonian for AdS_4 x CP^3 superstring

It is developed the phase-space formulation for the Type IIA superstring on the AdS_4 x CP^3 background in the kappa-symmetry light-cone gauge for which the light-like directions are taken from the D=3 Minkowski boundary of AdS_4. After fixing bosonic light-cone gauge the superstring Hamiltonian is expressed as a function of the transverse physical variables and in the quadratic approximation corresponds to the light-cone gauge-fixed IIA superstring in flat space.Comment: 12 pages, LaTeX; v2 minor improvements of the text, misprints corrected, reference added; v3: missing terms in Eqs.(8),(53) and (56) adde

The impact of providing blood to the scene of an accident on transfusion laboratory practice.

BACKGROUND: Haemorrhage is the leading cause of mortality during trauma. In 2012, London's Air Ambulance introduced Blood on Board (BOB), transfusing group O red cells (RBC) to trauma patients at the scene. OBJECTIVES: This study assessed the impact of BOB on the number of mixed field samples received by the laboratory, the number of group O RBC transfused to non-group O patients and the ratio of RBC to fresh frozen plasma (FFP) transfused in the initial 24 h. METHODS: Three major trauma centres collected data on patients for whom the major haemorrhage protocol was activated between August 2008 and February 2012 pre-BOB and March 2012 and December 2013 post-BOB. RESULTS: A total of 233 trauma patients were identified pre-BOB and 119 post-BOB. There was no significant difference in the percentage of group O units transfused to non-group O patients (75 vs 82%, P = 0·21) or the RBC : FFP ratio (pre-BOB mean 1·6 [interquartile range (IQR) 1·0-2·0]; post-BOB mean 1·7 [IQR 1·1-2·2], P = 0·24). There was no significant difference in the percentage of mixed field samples received (23% vs 27%, P = 0·3). CONCLUSION: The introduction of BOB did not change the proportion of group O RBC transfused or the RBC : FFP ratio; however, the proportion of acceptable samples decreased. This is largely due to an increase in blood samples not received from the post-BOB cohort, which we believe is probably due to patients who died at the scene. We have introduced robust systems to indicate reasons for not obtaining samples

Lemur tyrosine kinase-2 signalling regulates kinesin-1 light chain-2 phosphorylation and binding of Smad2 cargo

A recent genome wide association study identified the gene encoding lemur tyrosine kinase-2 (LMTK2) as a susceptibility gene for prostate cancer. The identified genetic alteration is within intron 9 but the mechanisms by which LMTK2 may impact upon prostate cancer are not clear because the functions of LMTK2 are poorly understood. Here, we show that LMTK2 regulates a known pathway that controls phosphorylation of kinesin-1 light chain-2 (KLC2) by glycogen synthase kinase-3β (GSK3β). KLC2 phosphorylation by GSK3β induces release of cargo from KLC2. LMTK2 signals via protein phosphatase-1C (PP1C) to increase inhibitory phosphorylation of GSK3β on serine-9 that reduces KLC2 phosphorylation and promotes binding of the known KLC2 cargo Smad2. Smad2 signals to the nucleus in response to transforming growth factor-β (TGFβ) receptor stimulation and transport of Smad2 by kinesin-1 is required for this signalling. We show that siRNA loss of LMTK2 not only reduces binding of Smad2 to KLC2 but also inhibits TGFβ-induced Smad2 signalling. Thus, LMTK2 may regulate the activity of kinesin-1 motor function and Smad2 signalling

Interactions of Cosmic Superstrings

We develop methods by which cosmic superstring interactions can be studied in detail. These include the reconnection probability and emission of radiation such as gravitons or small string loops. Loop corrections to these are discussed, as well as relationships to $(p,q)$-strings. These tools should allow a phenomenological study of string models in anticipation of upcoming experiments sensitive to cosmic string radiation.Comment: 22 pages, 6 figures; v2: updated reference

Optogalvanic Spectroscopy of Metastable States in Yb^{+}

The metastable ^{2}F_{7/2} and ^{2}D_{3/2} states of Yb^{+} are of interest for applications in metrology and quantum information and also act as dark states in laser cooling. These metastable states are commonly repumped to the ground state via the 638.6 nm ^{2}F_{7/2} -- ^{1}D[5/2]_{5/2} and 935.2 nm ^{2}D_{3/2} -- ^{3}D[3/2]_{1/2} transitions. We have performed optogalvanic spectroscopy of these transitions in Yb^{+} ions generated in a discharge. We measure the pressure broadening coefficient for the 638.6 nm transition to be 70 \pm 10 MHz mbar^{-1}. We place an upper bound of 375 MHz/nucleon on the 638.6 nm isotope splitting and show that our observations are consistent with theory for the hyperfine splitting. Our measurements of the 935.2 nm transition extend those made by Sugiyama et al, showing well-resolved isotope and hyperfine splitting. We obtain high signal to noise, sufficient for laser stabilisation applications.Comment: 8 pages, 5 figure

Two-loop Integrability of Planar N=6 Superconformal Chern-Simons Theory

Bethe ansatz equations have been proposed for the asymptotic spectral problem of AdS_4/CFT_3. This proposal assumes integrability, but the previous verification of weak-coupling integrability covered only the su(4) sector of the ABJM gauge theory. Here we derive the complete planar two-loop dilatation generator of N=6 superconformal Chern-Simons theory from osp(6|4) superconformal symmetry. For the osp(4|2) sector, we prove integrability through a Yangian construction. We argue that integrability extends to the full planar two-loop dilatation generator, confirming the applicability of the Bethe equations at weak coupling. Further confirmation follows from an analytic computation of the two-loop twist-one spectrum.Comment: 45 pages, v2: typos in (D.9) fixed, reference added, many small change