Feeding Patterns of Barren-ground Grizzly Bears in the Central Canadian Arctic

We collected 169 grizzly bear scats between 1994 and 1997 to determine the dietary habits of barren-ground grizzly bears (Ursus arctos) inhabiting Canada's central Arctic. From personal observations and fecal analysis, we concluded that barren-ground grizzly bears lead a predominantly carnivorous lifestyle and are effective predators of caribou (Rangifer tarandus). Caribou was a predominant diet item during spring, mid-summer, and fall. During early summer, grizzly bears foraged primarily on green vegetation. Berries increased in dietary importance in late summer. Declines in the caribou population of our study area or long-term absences of caribou may threaten the local grizzly bear population.On a prélevé 169 excréments de grizzli entre 1994 et 1997 afin de déterminer les habitudes alimentaires du grizzli de Richardson (Ursus arctos) qui vit dans le centre de l'Arctique canadien. En s'appuyant sur des observations personnelles et un examen coproscopique, on conclut que le grizzli de Richardson est un animal largement carnassier et qu'il est un prédateur efficace du caribou (Rangifer tarandus). Ce dernier constituait un aliment prédominant au printemps, au milieu de l'été et en automne. Au début de l'été, le grizzli se nourrissait surtout de végétation verte. À la fin de l'été, les baies prenaient plus d'importance dans son alimentation. Le déclin de la population du caribou dans la zone d'étude ou son absence prolongée peut constituer une menace pour la population locale de grizzlis

Mark-Recapture and Stochastic Population Models for Polar Bears of the High Arctic

We used mark-recapture data and population viability analysis (PVA) to estimate demographic parameters, abundance, and harvest risks for two adjacent populations of polar bears (Ursus maritimus) inhabiting Lancaster Sound and Norwegian Bay, Canada. Analyses were based on data from 1871 bears that were uniquely marked during the period 1972–97. Our best-fitting mark-recapture model specified sex and age effects on probabilities of survival and an effect of prior recapture (dependence) on capture probability. The most parsimonious solution in our analysis of survival was to assume the same rate for the Lancaster Sound and Norwegian Bay populations. Total (harvested) annual survival rates (mean ± 1 SE) for females included: 0.749 ± 0.105 (cubs), 0.879 ± 0.050 (ages 1–4), 0.936 ± 0.019 (ages 5– 20), and 0.758 ± 0.054 (ages 21+). Mean litter size was 1.69 ± 0.01 cubs for females of Lancaster Sound and 1.71 ± 0.08 cubs for females of Norwegian Bay. By age six, on average 0.31 ± 0.21 females of Lancaster Sound were producing litters (first age of reproduction was five years); however, females of Norwegian Bay did not reproduce until age seven or more. Total abundance (1995–97) averaged 2541 ± 391 bears in Lancaster Sound and 203 ± 44 bears in Norwegian Bay. The finite rate of increase (lambda) during the study period was estimated to be 1.001 ± 0.013 for bears of Lancaster Sound and 0.981 ± 0.027 for bears of Norwegian Bay. We incorporated demographic parameters into a harvest-explicit PVA to model short-term (15 yr) probabilities of overharvesting (i.e., 1997–2012). Our harvest simulations suggest that current levels of kill are approaching and perhaps exceeding the sustainable yield in both populations.Nous avons recouru aux données obtenues par marquage et recapture ainsi qu’aux analyses de viabilité de population pour estimer les paramètres démographiques, l’abondance et les risques liés à la récolte de deux populations adjacentes d’ours polaires (Ursus maritimus) évoluant dans le détroit de Lancaster et la baie Norwegian, au Canada. Les analyses reposaient sur les données relatives à 1 871 ours marqués de manière unique pendant la période allant de 1972 à 1997. Notre modèle de marquage et recapture le mieux ajusté tenait compte des effets du sexe et de l’âge sur les probabilités de survie, ainsi que de l’effet d’une recapture antérieure (dépendance) sur la probabilité de capture. La solution la plus parcimonieuse de notre analyse de survie consistait à assumer le même taux pour les populations du détroit de Lancaster et de la baie Norwegian. Les taux totaux de survie annuels (récoltés) (moyenne ± 1 SE) chez les femelles s’établissaient comme suit : 0,749 ± 0,105 (oursons), 0,879 ± 0,050 (âges 1-4), 0,936 ± 0,019 (âges 5-20), et 0,758 ± 0,054 (âges 21+). La grosseur moyenne des portées était de 1,69 ± 0,01 ourson dans le cas des femelles du détroit de Lancaster, et de 1,71 ± 0,08 ourson dans le cas des femelles de la baie Norwegian. Avant l’âge de six ans, en moyenne 0,31 ± 0,21 femelle du détroit de Lancaster produisait des portées (l’âge de reproduction le plus jeune était de cinq ans); cependant, les femelles de la baie Norwegian ne se reproduisaient pas avant l’âge de sept ans ou plus. L’abondance totale (1995-1997) atteignait en moyenne 2 541 ± 391 ours au détroit de Lancaster, et 203 ± 44 ours dans la baie Norwegian. Le taux fini d’augmentation (lambda) pendant la période d’étude était estimé à 1,001 ± 0,013 dans le cas des ours du détroit de Lancaster, et de 0,981 ± 0,027 dans le cas des ours de la baie Norwegian. Nous avons intégré les paramètres démographiques à une analyse de viabilité de population de récolte explicite pour modéliser les probabilités à court terme (15 ans) de surrécolte (i.e. 1997-2012). Nos simulations de récolte laissent croire que les taux d’ours tués approchent et peuvent même dépasser le rendement admissible des deux populations

Movements of Subadult Male Grizzly Bears, Ursus arctos, in the Central Canadian Arctic

Between May 1995 and June 1999, we equipped eight subadult male (3-5 yrs old) Grizzly Bears (Ursus arctos) with satellite radio-collars within a study area of 235,000 km2, centred 400 km northeast of Yellowknife, Northwest Territories, Canada. Subadult male annual home ranges were extraordinarily large (average = 11,407 km2, SE = 3849) due, in part, to their movement's occasional linear directionality. We believe their long-range linear movements may reflect some individuals tracking the migration of Caribou (Rangifer tarandus). Seasonal daily movement patterns were similar to adult males that were previously reported. The areas used by these bears are the largest ranges reported for any Grizzly Bears and the scale of their movements may put individual bears in contact with humans even when developments are hundreds of kilometres from the central home range of an animal

Population Viability of Barren-ground Grizzly Bears in Nunavut and the Northwest Territories

We modelled probabilities of population decline as a function of annual kill for a population of barren-ground grizzly bears (Ursus arctos) inhabiting Nunavut and the Northwest Territories, Canada. Our results suggest that the population is at risk of decline, especially if annual removal rates increase from the 42-year mean of 13.4 bears per year. Adding six bears to the mean annual kill results in a greater than 40% chance of a decrease by one-quarter in population size over the next 50 years, compared to a 10% chance with the current level of human-caused mortality. Additional mortalities may result from increased problem behaviour by bears at mine sites or hunt and exploration camps, given recent increases in human activity in the region, and may already be present as unreported mortality. We believe any increase in current harvest quotas would considerably lessen conservation prospects for the population.On a simulé les probabilités de baisse de la population en fonction du prélèvement annuel dans le cadre de la chasse pour une population de grizzlis de la toundra (Ursus arctos) habitant le Nunavut et les Territoires du Nord-Ouest, au Canada. Nos résultats suggèrent que la population risque de décliner, surtout si les taux de prélèvement augmentent par rapport à la moyenne établie sur 42 ans qui est de 13,4 ours par an. Le fait d'ajouter 6 ours au prélèvement de chasse annuel augmente à plus de 40 % le risque que la population décline d'un quart au cours des prochains 50 ans, par rapport à 10 % dans le cas du niveau actuel de mortalité provoquée par les humains. Vu l'augmentation récente de l'activité anthropique dans la région, d'autres individus pourraient être abattus à cause du nombre croissant de comportements problématiques des ours résidant à des sites miniers et à des campements d'exploration, et il est possible que ce phénomène existe déjà mais que les morts ne soient pas rapportées. Notre opinion est que toute augmentation des quotas actuels de prélèvement réduirait considérablement les perspectives de conservation pour la population

Demography and Viability of a Hunted Population of Polar Bears

We estimated demographic parameters and harvest risks for a population of polar bears (Ursus maritimus) inhabiting Baffin Bay, Canada and Greenland, from 1974 to 1997. Our demographic analysis included a detailed assessment of age- and sex-specific survival and recruitment from 1221 marked polar bears, which used information contained within the standing age distribution of captures and mark-recapture analysis performed with Program MARK. Unharvested (natural) survival rates for females (± 1 SE) from mark-recapture analysis were 0.620 ± 0.095 (cubs), 0.938 ± 0.042 (ages 1–4), 0.953 ± 0.020 (ages 5–20), and 0.919 ± 0.046 (ages 21+). Total (harvested) survival rates for females were reduced to 0.600 ± 0.096 (cubs), 0.901 ± 0.045 (ages 1–4), 0.940 ± 0.021 (ages 5–20), and 0.913 ± 0.047 (ages 21+). Mean litter size was 1.59 ± 0.07 cubs, with a mean reproductive interval of 2.5 ± 0.01 years. By age 5, on average 0.88 ± 0.40 of females were producing litters. We estimated the geometric means (± bootstrapped SDs) for population growth rates at stable age distribution as 1.055 ± 0.011 (unharvested) and 1.019 ± 0.015 (harvested). The model-averaged, mark-recapture estimate of mean abundance (± 1 SE) for years 1994–97 was 2074 ± 266 bears, which included 1017 ± 192 females and 1057 ± 124 males. We incorporated demographic parameters and their error terms into a harvest risk analysis designed to consider demographic, process, and sampling uncertainty in generating likelihoods of persistence (i.e., a stochastic, harvest-explicit population viability analysis). Using our estimated harvest of polar bears in Baffin Bay (88 bears/yr), the probability that the population would decline no more than could be recovered in five years was 0.95, suggesting that the current hunt is sustainable.De 1974 à 1997, on a évalué les paramètres démographiques d’une population d’ours polaires (Ursus maritimus) habitant la baie de Baffin (Canada et Groenland), ainsi que les risques associés à leur prélèvement. Notre analyse démographique comprenait un bilan détaillé de la survie et du recrutement par âge et par sexe, bilan mené sur 1221 ours polaires étiquetés et qui faisait appel à l’information contenue dans les limites de la structure d’âge des captures à un moment précis, ainsi que des analyses de marquage-recapture réalisées avec le logiciel MARK. Les taux de survie sans prélèvements (c’est-à-dire naturels) des femelles (± 1 erreur-type) tirés de l’analyse de marquage-recapture étaient les suivants: 0,620 ± 0,095 (oursons), 0,938 ± 0,042 (1–4 ans), 0,953 ± 0,020 (5–20 ans) et 0,919 ± 0,046 (21 ans et plus). Les taux de survie globaux (avec prélèvements) des femelles diminuaient à: 0,600 ± 0,096 (oursons), 0,901 ± 0,045 (1–4 ans), 0,940 ± 0,021 (5–20 ans) et 0,913 ± 0,047 (21 ans et plus). La taille moyenne des portées était de 1,59 ± 0,07 ourson avec des intervalles moyens de reproduction de 2,5 ± 0,01 ans. Arrivées à l’âge de cinq ans, en moyenne 0,88 ± 0,40 des femelles avaient eu des petits. On a évalué que les moyennes géométriques (± écart-type bootstrappé) pour les taux de croissance de la population à la structure d’âge stable étaient de 1,055 ± 0,011 (sans prélèvements) et de 1,019 ± 0,015 (avec prélèvements). La valeur estimée à partir du marquage-recapture, moyennée par le modèle, de l’abondance moyenne (± 1 erreur-type), pour les années allant de 1994 à 1997 était de 2074 ± 266 ours, dont 1017 Å} 192 femelles et 1057 ± 124 mâles. On a intégré les paramètres démographiques et leurs termes d’erreur dans une analyse des risques de prélèvements conçue pour tenir compte des incertitudes démographiques, de processus et d’échantillonnage lors du calcul des probabilités de persistance (c.-à-d. une analyse stochastique de la viabilité de la population qui tient compte des prélèvements). En se basant sur nos prélèvements estimés de l’ours polaire dans la baie de Baffin (88 ours/an), la probabilité que la population ne décline pas plus que ce qu’elle pourrait récupérer en 5 ans était de 0,95, ce qui suggère que la chasse actuelle est durable

Inhibition of major integrin αVβ3 reduces Staphylococcus aureus attachment to sheared human endothelial cells.

BACKGROUND: Vascular endothelial dysfunction with associated oedema and organ failure is one of the hallmarks of sepsis. While a large number of microorganisms can cause sepsis, Staphylococcus aureus is one of the primary etiological agents. Currently there are no approved specific treatments for sepsis and therefore the initial management bundle focuses on cardiorespiratory resuscitation and mitigation against the immediate threat of uncontrolled infection. The continuous emergence of antibiotic resistant strains of bacteria urges the development of new therapeutic approaches for this disease. OBJECTIVE: The objective of this study was to identify the molecular mechanisms leading to endothelial dysfunction as a result of Staphylococcus aureus binding. METHODS: Stahpylococcus aureus Newman and clumping factor A-deficient binding to endothelium were measured in vitro and in the mesenteric circulation of C57Bl/6 mice. The effect of the αVβ3 blocker, cilengitide, on bacterial binding, endothelial VE-cadherin expression, apoptosis, proliferation and permeability were assessed. RESULTS: Here we show that the major Staphylococcus aureus cell wall protein clumping factor A binds to endothelial cell integrin αVβ3 in the presence of fibrinogen. This interaction results in disturbances in barrier function mediated by VE-cadherin in endothelial cell monolayers and ultimately cell death by apoptosis. Using a low concentration of cilengitide, ClfA binding to αVβ3 was significantly inhibited both in vitro and in vivo. Moreover, preventing Staphylococcus aureus from attaching to αVβ3 resulted in a significant reduction in endothelial dysfunction following infection. CONCLUSION: Inhibition of Staphylococcus aureus ClfA binding to endothelial cell αVβ3 using cilengitide prevents endothelial dysfunction. This article is protected by copyright. All rights reserved

Absence of long-range ordered reconstruction on the GaAs(311)A surface

We have investigated the decapped GaAs(311)A surface using both scanning tunneling microscopy and synchrotron-radiation photoemission. While our data are in broad agreement with the structural model of GaAs(311)A proposed in a recent study [Wassermeier et al., Phys. Rev. B 51, 14 721 (1995)], we find considerable differences in the surface order. In particular, the As dimer rows are unbroken over much shorter length scales and are highly kinked. We observe a correspondingly lower degree of anisotropy in the surface roughness than that previously reported. An (8×1) reconstruction was not observed. An analysis of As 3d and Ga 3d core-level photoemission spectra suggests that surface As atoms are in only one bonding configuration while surface Ga adopts two different bonding states. We discuss possible origins for the core-level spectra surface components

Commonalities in EEG Spectral Power Abnormalities Between Women With ADHD and Women With Bipolar Disorder During Rest and Cognitive Performance

While attention-deficit/hyperactivity disorder (ADHD) and bipolar disorder (BD) denote distinct psy- chiatric conditions, diagnostic delineation is impeded by considerable symptomatic overlap. Direct comparisons across ADHD and BD on neurophysiological measures are limited. They could inform us on impairments that are specific to or shared between the disorders and, therefore, potential biomarkers that may aid in the identification of the diagnostic boundaries. Our aim was to test whether quantitative EEG (QEEG) identifies differences or imilarities between women with ADHD and women with BD during resting-state and task conditions. QEEG activity was directly compared between 20 ADHD, 20 BD and 20 control women during an eyes-open resting-state condition (EO) and a cued continuous performance task (CPT-OX). Both ADHD (t38 = 2.50, p = 0.017) and BD (t38 = 2.54, p = 0.018) participants showed higher absolute theta power during EO than controls. No significant differences emerged between the two clinical groups. While control participants showed a task-related increase in absolute theta power from EO to CPT-OX (t19 = -3.77, p = 0.001), no such change in absolute theta power was observed in the ADHD (t19 = -0.605, p = 0.553) or BD (t19 = 1.82, p = 0.084) groups. Our results provide evi- dence for commonalities in brain dysfunction between ADHD and BD. Absolute theta power may play a role as a marker of neurobiological processes in both disorders

Increasing density leads to generalization in both coarse-grained habitat selection and fine-grained resource selection in a large mammal

Summary 1. Density is a fundamental driver of many ecological processes including habitat selection. Theory on density-dependent habitat selection predicts that animals should be distributed relative to profitability of habitat, resulting in reduced specialization in selection (i.e. generalization) as density increases and competition intensifies. 2. Despite mounting empirical support for density-dependent habitat selection using isodars to describe coarse-grained (interhabitat) animal movements, we know little of how density affects fine-grained resource selection of animals within habitats [e.g. using resource selection functions (RSFs)]. 3. Using isodars and RSFs, we tested whether density simultaneously modified habitat selection and within-habitat resource selection in a rapidly growing population of feral horses (Equus ferus caballus Linnaeus; Sable Island, Nova Scotia, Canada; 42% increase in population size from 2008 to 2012). 4. Among three heterogeneous habitat zones on Sable Island describing population clusters distributed along a west-east resource gradient (west-central-east), isodars revealed that horses used available habitat in a density-dependent manner. Intercepts and slopes of isodars demonstrated a pattern of habitat selection that first favoured the west, which generalized to include central and east habitats with increasing population size consistent with our understanding of habitat quality on Sable Island. 5. Resource selection functions revealed that horses selected for vegetation associations similarly at two scales of extent (total island and within-habitat zone). When densities were locally low, horses were able to select for sites of the most productive forage (grasslands) relative to those of poorer quality. However, as local carrying capacity was approached, selection for the best of available forage types weakened while selection for lower-quality vegetation increased (and eventually exceeded that of grasslands). 6. Isodars can effectively describe coarse-grained habitat selection in large mammals. Our study also shows that the main predictions of density-dependent habitat selection are highly relevant to our interpretation of RSFs in space and time. At low but not necessarily high population size, density will be a leading indicator of habitat quality. Fitness maximization from specialist vs. generalist strategies of habitat and resource selection may well be apparent at multiple spatial extents and grains of resolution