Self-Compassion and Suicide Risk in Veterans: Serial Effects of Shame, Guilt, and PTSD

Suicide is a significant public health concern and ranks as the 10th leading cause of death in the U.S. Veterans are at a disproportionately higher risk for suicide, due to risk factors such as exposure to trauma and its negative cognitive-emotional sequalae, such as PTSD, shame, and guilt. However, not all veterans exposed to traumatic events, or who experience shame and guilt, die by suicide, perhaps as a result of the presence of individual-level protective factors such as self-compassion. Conceptualized as self-kindness, mindfulness and common humanity, self-compassion is beneficially associated with mental and physical health, including reduced suicide risk. We examined the potential serial mediating effects of shame/guilt, separated into two models, and PTSD in the relation between self-compassion and suicide risk in a sample of U.S. veterans (N = 317). Participants in our IRB-approved study provided informed consent and completed the Self-Compassion Scale - Short Form, Differential Emotions Scale-IV, PTSD Checklist-Military Version (PCL-M) for DSM-IV, and Suicidal Behaviors Questionnaire - Revised (SBQ-R). Supporting hypotheses, shame/guilt and PTSD, and PTSD alone, mediated the relation between self-compassion and suicide risk, but shame/guilt alone did not. Our results remained significant when covarying depressive symptoms. Therapeutic interventions such as Mindful Self-Compassion and Compassion-Focused Therapy may increase self-compassion and ameliorate negative cognitive-emotional sequelae, including suicide risk, in veterans

A Normal-Mixture Model with Random-Effects for RR-Interval Data

In many applications of random-effects models to longitudinal data, such as heart rate variability (HRV) data, a normal-mixture distribution seems to be more appropriate than the normal distribution assumption. While the random-effects methodology is well developed for several distributions in the exponential family, the case of the normal-mixture has not been dealt with adequately in the literature. The models and the estimation methods that have been proposed in the past assume the conditional model (fixing the random-effects) to be normal and allow a mixture distribution for the random effects (Xu and Hedeker, 2001, Xu, 1995). The methods proposed in this dissertation assume the conditional model to be a normal-mixture while the random-effects are assumed to be normal. This is primarily to fit the HRV data, which seems to follow a normal-mixture within subjects. Another advantage of this model is that the estimation becomes much simpler through the use of an EM-algorithm. Existing methods and software such as the PROC MIXED in SAS are exploited to facilitate the estimation procedure.A simulation study is performed to examine the properties of the random-effects model with normal-mixture distribution and the estimation of the parameters using the EM-algorithm. The study shows that the estimates have similar properties to the usual normal random-effects models. The between subject variance parameter seems to require larger numbers of subjects to achieve reasonable accuracy, which is typical in all random-effects models.The HRV data is used to illustrate the random-effects normal-mixture method. These data consist of 9 subjects who completed a series of five speech tasks (Cacioppo et al., 2002). For each of the tasks, a series of RR-intervals was collected during baseline, preparation, and delivery periods. Information about their age and gender were also available. The random-effects mixture model presented in this dissertation treats the subjects as random and models age, gender, task, type, and task × type as fixed-effects. The analysis leads to the conclusion that all the fixed effects are statistically significant. The model further indicates a two-component normal-mixture with the same mixture proportion across individuals fit the data adequately

Odor sensitivity and the presence of p-cresol

Olfactory function declines throughout the different stages of kidney disease. End-stage renal disease (ESRD) patients have experienced improved olfactory function after dialysis, leading some researchers to suspect uremic toxins as the cause of olfactory decline (Raff et al., 2008; Bomback & Raff, 2011). It is thought that p-cresol is the specific uremic toxin to cause a decline in olfactory function because it is not easily filtered out of the blood during dialysis (Meijers et al., 2010). The study sought to set up a control group for future studies by demonstrating p-cresol is not in the blood of healthy participants and to collect normative values for an olfactory threshold test. Results supported the hypothesis that p-cresol is not present in the blood of healthy participants, which strengthens the idea that p-cresol may be the cause of olfactory dysfunction in ESRD patients

Self-handicapping mediates between impulsiveness and self-discipline

Self-handicapping, while not a very acknowledged tendency, is very prevalent today. Especially among students of any grade level, the behavior prevents many from reaching their full potential. The purpose of this experiment was to see how Selfhandicapping mediated between Impulsiveness and Self-discipline which can later be used by teachers to help students with this phenomenon. A short survey was given to psychology undergraduate students at the University of Tennessee-Chattanooga whose age ranged from 18-44 and were predominantly Caucasian. Self-handicapping was found to mediate between Impulsiveness and Self-discipline (r = .512) compared to Impulsiveness and Self-discipline (r= .288) without using self-handicapping as a mediator. The implications that can be taken from this study include using the results in an educational setting to pinpoint selfhandicapping tendencies. Despite limitations in the study, it was conducted in an environment that was cohesive to the environment in which it would be applied

Measurement of Participation: The Role Checklist Version 3: Satisfaction and Performance

Participation in society is an area of interest to both clinicians and population researchers. Measurement of participation is therefore important, yet differences in definition, in terms of both content and scope, have made general agreement on one instrument tool elusive. What is recognized is the need for a theoretically based tool that captures both the insider and the outsider perspective. The outsider perspective, inclusive of the generally held views of a society, supports the utility for aggregating population data, whereas the insider perspective provides the internally held views of an individual needed for client-centered treatment planning. The Role Checklist Version 3 modifies one of the most commonly used assessment tools in occupational therapy practice, has good preliminary psychometric properties, and is theoretically consistent with both the ICF and the Model of Human Occupation. The Model of Human Occupation is the most widely used theoretical model in occupational therapy. This chapter provides an overview of the theoretical development, empirical testing, and implications for use of this participation measure by occupational therapists along with implications for population researchers

Correction to: A digital health program for treatment of urinary incontinence: retrospective review of real‑world user data (International Urogynecology Journal, (2023), 34, 5, (1083-1089), 10.1007/s00192-022-05321-3)

The article “A digital health program for treatment of urinary incontinence: retrospective review of real‑world user data”, written by Laura E. Keyser, Jessica L. McKinney, Samantha J. Pulliam, and Milena M. Weinstein, was originally published Online First without Open Access. After publication in volume 34, issue 5, pages 1083–1089 the author decided to opt for Open Choice and to make the article an Open Access publication. Therefore, the copyright of the article has been changed to © The Author(s) 2022 and the article is forthwith distributed under the terms of the Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article\u27s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article\u27s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit. The original article has been corrected

Dynamic fibronectin assembly and remodeling by leader neural crest cells prevents jamming in collective cell migration

Collective cell migration plays an essential role in vertebrate development, yet the extent to which dynamically changing microenvironments influence this phenomenon remains unclear. Observations of the distribution of the extracellular matrix (ECM) component fibronectin during the migration of loosely connected neural crest cells (NCCs) lead us to hypothesize that NCC remodeling of an initially punctate ECM creates a scaffold for trailing cells, enabling them to form robust and coherent stream patterns. We evaluate this idea in a theoretical setting by developing an agent-based model that incorporates reciprocal interactions between NCCs and their ECM. ECM remodeling, haptotaxis, contact guidance, and cell-cell repulsion are sufficient for cells to establish streams in silico, however additional mechanisms, such as chemotaxis, are required to consistently guide cells along the correct target corridor. Further investigations of the model imply that contact guidance and differential cell-cell repulsion between leader and follower cells are key contributors to robust collective cell migration by preventing stream breakage. Global sensitivity analysis and simulated underexpression/overexpression experiments suggest that long-distance migration without jamming is most likely to occur when leading cells specialize in creating ECM fibers, and trailing cells specialize in responding to environmental cues by upregulating mechanisms such as contact guidance.Comment: 46 pages, 7 figures (of which 2 are supplementary

Development and Pilot Test of a Multi-Component Intervention to Support Womens Recovery from Female Genital Fistula.

INTRODUCTION AND HYPOTHESIS: We evaluated a pilot multi-component reintegration intervention to improve womens physical and psychosocial quality of life after genital fistula surgery. METHODS: Twelve women undergoing fistula repair at Mulago Specialized Women and Neonatal Hospital (Kampala, Uganda) anticipated in a 2-week multi-component intervention including health education, psychosocial therapy, physiotherapy, and economic investment. We assessed feasibility through recruitment, retention, and adherence, acceptability through intervention satisfaction, and preliminary effectiveness through reintegration, mental health, physical health, and economic status. We collected quantitative data at enrollment, 6 weeks, 3 months, and 6 months. We conducted in-depth interviews with six participants. Quantitative data are presented descriptively, and qualitative data analyzed thematically. RESULTS: Participants had a median age of 34.5 years (25.5-38.0), 50% were married/partnered, 42% were separated, 50$ had completed less than primary education, and 67% were unemployed. Mean number of sessions received was 12 for health education (range 5-15), 8 for counseling (range 8-9), and 6 for physiotherapy (range 4-8). Feasibility was demonstrated by study acceptance among all those eligible (100%); comfort with study measures, data collection frequency and approach; and procedural fidelity. Acceptability was high; all participants reported being very satisfied with the intervention and each of the components. Participant narratives echoed quantitative findings and contributed nuanced perspectives to understanding approach and content. CONCLUSIONS: Our results suggest that the intervention and associated research were both feasible and acceptable, and suggested certain modifications to the intervention protocol to reduce participant burden. Further research to determine the effectiveness of the intervention above and beyond surgery alone with regard to the health and well-being of women with fistulas is warranted

Mechanopathology of Biofilm-like Mycobacterium Tuberculosis Cords

Mycobacterium tuberculosis (Mtb) cultured axenically without detergent forms biofilm-like cords, a clinical identifier of virulence. In lung-on-chip (LoC) and mouse models, cords in alveolar cells contribute to suppression of innate immune signaling via nuclear compression. Thereafter, extracellular cords cause contact-dependent phagocyte death but grow intercellularly between epithelial cells. The absence of these mechanopathological mechanisms explains the greater proportion of alveolar lesions with increased immune infiltration and dissemination defects in cording-deficient Mtb infections. Compression of Mtb lipid monolayers induces a phase transition that enables mechanical energy storage. Agent-based simulations demonstrate that the increased energy storage capacity is sufficient for the formation of cords that maintain structural integrity despite mechanical perturbation. Bacteria in cords remain translationally active despite antibiotic exposure and regrow rapidly upon cessation of treatment. This study provides a conceptual framework for the biophysics and function in tuberculosis infection and therapy of cord architectures independent of mechanisms ascribed to single bacteria

Oral Resveratrol Therapy Inhibits Cancer-Induced Skeletal Muscle and Cardiac Atrophy In Vivo

The mechanism by which cancer mediates muscle atrophy has been delineated in the past 3 decades, and includes a prominent role of tumor-derived cytokines, such as IL-6, TNFα and IL-1. These cytokines interact with their cognate receptors on muscle to activate the downstream transcription factor NF-κB and induce sarcomere proteolysis. Experimentally, inhibiting NF-κB signaling largely prevents cancer-induced muscle wasting, indicating its prominent role in muscle atrophy. Resveratrol, a natural phytoalexin found in the skin of grapes, has recently been shown to inhibit NF-κB in cancer cells, which led us to hypothesize that it might have a protective role in cancer cachexia. Therefore, we investigated if daily oral resveratrol could protect against skeletal muscle loss and cardiac atrophy in an established mouse model. We demonstrate resveratrol inhibits skeletal muscle and cardiac atrophy induced by C26 adenocarcinoma tumors through its inhibition of NF-κB (p65) activity in the skeletal muscle and heart. These studies demonstrate for the first time the utility of oral resveratrol therapy to provide clinical benefit in cancer-induced atrophy through the inhibition of NF-κB in muscle. These findings may have application in the treatment of diseases with parallel pathophysiologies such as muscular dystrophy and heart failure