266 research outputs found
Comorbidities, exposure to medications, and the risk of community-acquired clostridium difficile infection: A systematic review and meta-analysis
Background. Clostridium difficile infection (CDI) has been extensively escribedin healthcare settings; however, risk factor sassociated with community-acquired (CA) CDI remain uncertain. This study aimed to synthesize the current evidence for an association between commonly prescribed medications and comorbidities with CA-CDI. methods. A systematic search was conducted in 5 electronic databases for epidemiologicstudi esthatexamined the associtation between the presence of comorbidities and exposure to medications with the risk of CA-CDI. Pooled odds ratios were estimated using 3 meta-analytic methods. Subgroup analyses by location of studies and by life stages were conducted. results. Twelve publications (n=56,776 patients) met inclusion criteria. Antimicrobial (odds ratio, 6.18; 95% CI, 3.80-10.04) and corticosteroid (1.81; 1.15-2.84) exposure were associated with increased risk of CA-CDI. Among the comorbidities, inflammatory bowel disease (odds ratio, 3.72; 95% CI, 1.52-9.12), renal failure (2.64; 1.23-5.68), hematologic cancer (1.75; 1.02-5.68), and diabetes mellitus (1.15; 1.05-1.27) were associated with CA-CDI. By location, antimicrobial exposure was associated with a higher risk of CA-CDI in the United States, whereas proton-pump inhibitor exposure was associated with a higher risk in Europe. By life stages, the risk of CA-CDI associated with antimicrobial exposure greatly increased in adults older than 65 years. conclusions. Antimicrobial exposure was the strongest risk factor associated with CA-CDI. Further studies are required to investigate the risk of CA-CDI associated with medications commonly prescribed in the community. Patients with diarrhea who have inflammatory bowel disease, renal failure, hematologic cancer, or diabetes are appropriate populations for interventional studies of screening
A Precious Bequest: Contemporary Research with the WPA-CCC Collections from Moundville, Alabama *
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/72459/1/j.1749-6632.1981.tb28184.x.pd
Advancing groundwater vulnerability assessment in the Yukon and Northwest Territories
This research was undertaken, thanks, in part, to support from the Global Water Futures Program funded by the Canada First Research Excellence Fund (CFREF).Reliance on groundwater for drinking water supplies varies across the Yukon and Northwest Territories (NWT), with usage of up to 97% in Yukon and 5% in NWT. Groundwater vulnerability assessments, which review water quality concerns such as the susceptibility for aquifers or wells to become contaminated in a specified area, have been developed in southern regions and their applicability within cold regions is uncertain. The approach of the present study was to learn from Indigenous Elders and community members about local water concerns in several communities, to develop tools for assessing groundwater vulnerability, and to recommend strategies for assessing northern groundwater vulnerability. Challenges such as climate change and permafrost thaw were reviewed, as well as contaminated sites records across the Yukon and NWT. A web app was developed for visualizing theoretical well capture zones for aquifers with simplified geometry that are bounded by surface water features. A fully integrated surface water – groundwater model was also developed for one community to assess well vulnerability to increasing summer peaks flows in the Yukon River. Two-dimensional modelling of permafrost thaw has been conducted to explore the dynamics of solute transport in supra- and subpermafrost aquifer regions, which could assist with understanding releases from waste disposal sites such as landfills that historically relied on permafrost for waste containment. Recommendations include valuing both Indigenous and Western knowledge perspectives, starting with the development of “groundwater intuition” and easily implemented methods and developing ways to test hypotheses, and integrating hydrogeologic information with geochemistry.CFREF Global Water Futures, New Tools for Northern Groundwater Vulnerability Assessment || CFREF Global Water Futures, Core Modelling Tea
Extension to order of the high-temperature expansions for the spin-1/2 Ising model on the simple-cubic and the body-centered-cubic lattices
Using a renormalized linked-cluster-expansion method, we have extended to
order the high-temperature series for the susceptibility
and the second-moment correlation length of the spin-1/2 Ising models on
the sc and the bcc lattices. A study of these expansions yields updated direct
estimates of universal parameters, such as exponents and amplitude ratios,
which characterize the critical behavior of and . Our best
estimates for the inverse critical temperatures are
and . For the
susceptibility exponent we get and for the correlation
length exponent we get .
The ratio of the critical amplitudes of above and below the critical
temperature is estimated to be . The analogous ratio for
is estimated to be . For the correction-to-scaling
amplitude ratio we obtain .Comment: Misprints corrected, 8 pages, latex, no figure
Transport properties of strongly correlated metals:a dynamical mean-field approach
The temperature dependence of the transport properties of the metallic phase
of a frustrated Hubbard model on the hypercubic lattice at half-filling are
calculated. Dynamical mean-field theory, which maps the Hubbard model onto a
single impurity Anderson model that is solved self-consistently, and becomes
exact in the limit of large dimensionality, is used. As the temperature
increases there is a smooth crossover from coherent Fermi liquid excitations at
low temperatures to incoherent excitations at high temperatures. This crossover
leads to a non-monotonic temperature dependence for the resistance,
thermopower, and Hall coefficient, unlike in conventional metals. The
resistance smoothly increases from a quadratic temperature dependence at low
temperatures to large values which can exceed the Mott-Ioffe-Regel value, hbar
a/e^2 (where "a" is a lattice constant) associated with mean-free paths less
than a lattice constant. Further signatures of the thermal destruction of
quasiparticle excitations are a peak in the thermopower and the absence of a
Drude peak in the optical conductivity. The results presented here are relevant
to a wide range of strongly correlated metals, including transition metal
oxides, strontium ruthenates, and organic metals.Comment: 19 pages, 9 eps figure
An Observational Overview of Solar Flares
We present an overview of solar flares and associated phenomena, drawing upon
a wide range of observational data primarily from the RHESSI era. Following an
introductory discussion and overview of the status of observational
capabilities, the article is split into topical sections which deal with
different areas of flare phenomena (footpoints and ribbons, coronal sources,
relationship to coronal mass ejections) and their interconnections. We also
discuss flare soft X-ray spectroscopy and the energetics of the process. The
emphasis is to describe the observations from multiple points of view, while
bearing in mind the models that link them to each other and to theory. The
present theoretical and observational understanding of solar flares is far from
complete, so we conclude with a brief discussion of models, and a list of
missing but important observations.Comment: This is an article for a monograph on the physics of solar flares,
inspired by RHESSI observations. The individual articles are to appear in
Space Science Reviews (2011
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