957 research outputs found
Invited commentary on Stewart and Davis " 'Big data' in mental health research-current status and emerging possibilities"
No abstract available
Hippocampal and amygdala volumes in borderline personality disorder: A meta-analysis of magnetic resonance imaging studies
Cholinergic Modulation of Locomotion and Striatal Dopamine Release Is Mediated by α6α4* Nicotinic Acetylcholine Receptors
Dopamine (DA) release in striatum is governed by firing rates of midbrain DA neurons, striatal cholinergic tone, and nicotinic ACh
receptors (nAChRs) on DA presynaptic terminals. DA neurons selectively express α6* nAChRs, which show high ACh and nicotine
sensitivity. To help identify nAChR subtypes that control DA transmission, we studied transgenic mice expressing hypersensitive α6^(L9’S*)
receptors. α6^(L9’S) mice are hyperactive, travel greater distance, exhibit increased ambulatory behaviors such as walking, turning, and
rearing, and show decreased pausing, hanging, drinking, and grooming. These effects were mediated by α6 α4* pentamers, as α6^(L9’S) mice
lacking α4 subunits displayed essentially normal behavior. In α6^(L9’S) mice, receptor numbers are normal, but loss of α4 subunits leads to
fewer and less sensitive α6* receptors. Gain-of-function nicotine-stimulated DA release from striatal synaptosomes requires α4 subunits,
implicating α6α4β2* nAChRs in α6^(L9’S) mouse behaviors. In brain slices, we applied electrochemical measurements to study
control of DA release by α6^(L9’S) nAChRs. Burst stimulation of DA fibers elicited increased DA release relative to single action potentials
selectively in α6^(L9’S), but not WT or α4KO/ α6^(L9’S), mice. Thus, increased nAChR activity, like decreased activity, leads to enhanced
extracellular DA release during phasic firing. Bursts may directly enhance DA release from α6^(L9’S) presynaptic terminals, as there was no
difference in striatal DA receptor numbers or DA transporter levels or function in vitro. These results implicate α6α4β2* nAChRs in
cholinergic control of DA transmission, and strongly suggest that these receptors are candidate drug targets for disorders involving the
DA system
Cognitive ability in early life and risk of depression in adulthood: A systematic review and meta-analysis
A new population of recently quenched elliptical galaxies in the SDSS
We use the Sloan Digital Sky Survey to investigate the properties of massive
elliptical galaxies in the local Universe (z\leq0.08) that have unusually blue
optical colors. Through careful inspection, we distinguish elliptical from
non-elliptical morphologies among a large sample of similarly blue galaxies
with high central light concentrations (c_r\geq2.6). These blue ellipticals
comprise 3.7 per cent of all c_r\geq2.6 galaxies with stellar masses between
10^10 and 10^11 h^{-2} {\rm M}_{\sun}. Using published fiber spectra
diagnostics, we identify a unique subset of 172 non-star-forming ellipticals
with distinctly blue urz colors and young (< 3 Gyr) light-weighted stellar
ages. These recently quenched ellipticals (RQEs) have a number density of
2.7-4.7\times 10^{-5}\,h^3\,{\rm Mpc}^{-3} and sufficient numbers above
2.5\times10^{10} h^{-2} {\rm M}_{\sun} to account for more than half of the
expected quiescent growth at late cosmic time assuming this phase lasts 0.5
Gyr. RQEs have properties that are consistent with a recent merger origin
(i.e., they are strong `first-generation' elliptical candidates), yet few
involved a starburst strong enough to produce an E+A signature. The preferred
environment of RQEs (90 per cent reside at the centers of < 3\times
10^{12}\,h^{-1}{\rm M}_{\sun} groups) agrees well with the `small group scale'
predicted for maximally efficient spiral merging onto their halo center and
rules out satellite-specific quenching processes. The high incidence of Seyfert
and LINER activity in RQEs and their plausible descendents may heat the
atmospheres of small host halos sufficiently to maintain quenching.Comment: 26 pages, 9 figures. Revised version; accepted for publication in
MNRA
DNA methylome-wide association study of genetic risk for depression implicates antigen processing and immune responses
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