3,459 research outputs found
Dydrogesterone and norethisterone regulate expression of lipoprotein lipase and hormones-sensitive lipase in human subcutaneous abdominal adipocytes
Aim: In premenopausal women, hyper-androgenicity is associated with central obesity and an increased cardiovascular risk. We investigated the effects of dydrogesterone (DYD)(a non-androgenic progestogen) and norethisterone (NET)(an androgenic progestogen) on lipoprotein lipase (LPL), hormone-sensitive lipase (HSL) and glycerol release in adipocytes isolated from subcutaneous abdominal adipose tissue. Methods: Adipose tissue was obtained from 12 non-diabetic women, mean age 51 years (range 37-78) and mean BMI 25.4kg/m2 (range 20.3-26.4). Adipocytes were treated with increasing doses of DYD and NET for 48 hours prior to protein extraction. Effects on lipogenesis and lipolysis were assessed using western blotting to determine the expression of key enzymes, LPL (56kDa) and HSL (84kDa) respectively. Measurement of glycerol release into the medium provided an assessment of lipolytic activity. Results: Expression of LPL was increased by DYD and NET (mean protein expression relative to control ± SEM); with greatest effect at 10-8M for DYD: 2.32±0.51(p0.05). Conclusions: DYD and NET significantly increased LPL expression relative to control whilst significantly reducing HSL expression. At the concentrations studied, similar effects were observed with the androgenic NET and the non-androgenic DYD despite differing effects on the lipid profile when taken
in combination with estrogen. Further work in this area may improve knowledge about the effects of different progestogens on body fat distribution and enable progestogen use to be tailored to the individual to achieve maximal benefits
Vibrational measurement for commissioning SRF Accelerator Test Facility at Fermilab
The commissioning of two cryomodule components is underway at Fermilab's
Superconducting Radio Frequency (SRF) Accelerator Test Facility. The research
at this facility supports the next generation high intensity linear
accelerators such as the International Linear Collider (ILC), a new high
intensity injector (Project X) and other future machines. These components,
Cryomodule #1 (CM1) and Capture Cavity II (CC2), which contain 1.3 GHz cavities
are connected in series in the beamline and through cryogenic plumbing. Studies
regarding characterization of ground motion, technical and cultural noise
continue. Mechanical transfer functions between the foundation and critical
beamline components have been measured and overall system displacement
characterized. Baseline motion measurements given initial operation of
cryogenic, vacuum systems and other utilities are considered.Comment: 3 pp. Particle Accelerator, 24th Conference (PAC'11) 2011. 28 Mar - 1
Apr 2011. New York, US
The Stellar Content of Obscured Galactic Giant H II Regions IV.: NGC3576
We present deep, high angular resolution near-infrared images of the obscured
Galactic Giant H II region NGC3576. Our images reach objects to ~3M_sun. We
collected high signal-to-noise K-band spectra of eight of the brightest
objects, some of which are affected by excess emission and some which follow a
normal interstellar reddening law. None of them displayed photospheric features
typical of massive OB type stars. This indicates that they are still enshrouded
in their natal cocoons. The K-band brightest source (NGC3576 #48) shows CO 2.3
micron bandhead emission, and three others have the same CO feature in
absorption. Three sources display spatially unresolved H_2 emission, suggesting
dense shocked regions close to the stars. We conclude that the remarkable
object NGC3576 #48 is an early-B/late-O star surrounded by a thick
circumstellar disk. A number of other relatively bright cluster members also
display excess emission in the K-band, indicative of reprocessing disks around
massive stars (YSOs). Such emission appears common in other Galactic Giant H II
regions we have surveyed. The IMF slope of the cluster, Gamma = -1.51, is
consistent with Salpeter's distribution and similar to what has been observed
in the Magellanic Cloud clusters and in the periphery of our Galaxy.Comment: 14 pages, 11 figures, accepted for publication in A
NGC 3576 and NGC 3603: Two Luminous Southern HII Regions Observed at High Resolution with the Australia Telescope Compact Array
NGC 3576 (G291.28-0.71; l=291.3o, b=-0.7o) and NGC 3603 (G291.58-0.43;
l=291.6o, b=-0.5o) are optically visible, luminous HII regions located at
distances of 3.0 kpc and 6.1 kpc, respectively. We present 3.4 cm Australian
Telescope Compact Array (ATCA) observations of these two sources in the
continuum and the H90a, He90a, C90a and H113b recombination lines with an
angular resolution of 7" and a velocity resolution of 2.6 km/s. All four
recombination lines are detected in the integrated profiles of the two sources.
Broad radio recombination lines are detected in both NGC 3576 (DV_{FWHM}>= 50
km/s) and NGC 3603 (DV_{FWHM}>=70 km/s). In NGC 3576 a prominent N-S velocity
gradient (~30 km/s/pc) is observed, and a clear temperature gradient (6000 K to
8000 K) is found from east to west, consistent with a known IR color gradient
in the source. In NGC 3603, the H90a, He90a and the H113b lines are detected
from 13 individual sources. The Y^+ (He/H) ratios in the two sources range from
0.08+/-0.04 to 0.26+/-0.10. We compare the morphology and kinematics of the
ionized gas at 3.4 cm with the distribution of stars, 10 micron emission and
H_2O, OH, and CH_3OH maser emission. These comparisons suggest that both NGC
3576 and NGC 3603 have undergone sequential star formation.Comment: 24 pages, 12 Postscript figure
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