269 research outputs found

    Rehabilitation interventions to modify physical frailty in adults before lung transplantation: A systematic review protocol

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    Introduction: Lung transplantation is the gold standard treatment for end-stage lung disease for a small group of patients meeting strict acceptance criteria after optimal medical management has failed. Physical frailty is prevalent in lung transplant candidates and has been linked to worse outcomes both on the waiting list and postoperatively. Exercise has been proven to be beneficial in optimising exercise capacity and quality of life in lung transplant candidates but its impact on physical frailty is unknown. This review aims to assess the effectiveness of exercise interventions in modifying physical frailty for adults awaiting lung transplantation. Methods and Analysis: This protocol was prospectively registered on the PROSPERO database. We will search four databases plus trials registries to identify primary studies of adult candidates for lung transplantation undertaking exercise interventions and assessing outcomes pertaining to physical frailty. Studies must include at least ten participants. Article screening will be performed by two researchers independently at each stage. Extraction will be performed by one reviewer and checked by a second. The risk of bias in studies will be assessed by two independent reviewers using tools appropriate for the research design of each study; where appropriate we will use Cochrane risk of bias 2 or ROBINS-I. At each stage of the review process discrepancies will be resolved through consensus or consultation with a third reviewer. Meta-analyses of frailty outcomes, will be performed if possible and appropriate as will pre-specified subgroup and sensitivity analyses. Where we are unable to perform meta-analysis we will conduct narrative synthesis following SWiM guidance. The review will be reported using the PRISMA Checklist.Ethics and Dissemination: No ethical issues are predicted due to the nature of this study. Dissemination will occur via conference abstracts, professional networks, peer reviewed journals and patient support groups. Registration Details: PROSPERO registration number CRD42022363730

    Emergence of a spin microemulsion in spin-orbit coupled Bose-Einstein condensates

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    We report the first observation of a ``spin microemulsion''-- a phase with undulating spin domains resembling classical bicontinuous oil-water-surfactant emulsions -- in two-dimensional systems of spinor Bose-Einstein condensates with isotropic Rashba spin-orbit coupling. Using field-theoretic numerical simulations, we investigated the melting of a low-temperature stripe phase with supersolid character and find that the stripes lose their superfluidity at elevated temperature and undergo a Kosterlitz--Thouless-like transition into a spin microemulsion. Momentum distribution calculations highlight a thermally broadened occupation of the Rashba circle of low-energy states with macroscopic and isotropic occupation around the ring. We provide a finite-temperature phase diagram that positions the emulsion as an intermediate, structured isotropic phase with residual quantum character before transitioning at higher temperature into a structureless normal fluid.Comment: Main text: 6 pages, 5 figures. Supplementary Material: 5 pages, 5 figure

    Ambivalence and transnational intergenerational solidarity: the perspective of highly educated Portuguese women emigrant daughters

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    peer reviewedExisting literature has highlighted solidarity across generations as a crucial mechanism for transfers and maintaining cohesion within families. However, researching solidarity across generations among transnational families is still an underexplored area, especially from the viewpoint of highly skilled female migrants. This study explored the way highly educated Portuguese adult daughters, living transnationally, perceive the existing solidarity ties with their parents, in times of transition, such as during the process of migration. By using a cluster analysis approach to explore the statistical associations between ambivalence and intergenerational solidarity dimensions, this study provides insight into the migrant solidarity types incorporating the role of ambivalence in forging a typology of transnational intergenerational relationships. The sample comprised 248 daughters who volunteered to provide information in an online survey. Participants gave their full consent to partake in this study, and this study was approved by the ethical committee of the authors’ institution. Measures of intergenerational solidarity dimensions, perceived ambivalence, sociocultural adaptation, acculturation, and social well-being in the destination country were included in the survey. Model-based cluster analysis resulted in three clusters: low ambivalence with strong cohesion, autonomous with affection and low ambivalence, and ambivalent functional ties with low affection. These clusters differed significantly in terms of intergenerational solidarity dimensions, perceived ambivalence, and in several other measures addressed. Perceived high parent-daughter ambivalent ties were associated with high levels of functional contacts and financial exchange. That pattern was also associated with lower levels of affection and consensus, being most frequently found in older daughters, mostly when single, economically inactive, or unemployed. Low perceived ambivalent parent-daughter ties were the most frequently found (around 80%), with two different types of intergenerational relationships being revealed, namely the low ambivalence with strong cohesion type and the autonomous with affection and low ambivalence type. Half (50%) of the daughters that perceived low parent-daughter ambivalent ties have associated the highest intergenerational solidarity, being, in general, better adapted to the migration context and slightly younger on average. The other half, less well acculturated, living abroad for longer, in countries with stronger welfare state systems and less reliance on families as providers of care, are more associated with an autonomous relationship type with low solidarity, but high affection. These results suggest that there might be a spillover effect: those who fare well in the country of migration, have better relations with their families at home—either being very interdependent or very independent, but always with good affective quality and low ambivalence.3. Good health and well-bein

    (2S)-2-[(2S*,5R*,6R*)-5,6-Dimeth­oxy-5,6-dimethyl-1,4-dioxan-2-yl]-1-[(S)-1,1-dimethyl­ethylsulfon­yl]aziridine

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    The reaction of a sulfur ylide with a chiral non-racemic sulfinyl imine afforded the desired aziridine in excellent yield and subsequent oxidation of the sulfinyl moiety dissolved in anhydrous dichloro­methane using a 75% aqueous solution of 3-chloro­per­oxy­benzoic acid afforded the title compound, C14H27NO6S. The configuration of the newly formed stereogenic center at the point of attachment of the 1,4-dioxane ring to the aziridine ring is S. The configurations of the pre-existing sites 2-, 5-, and 6-positions of the 1,4-dioxane ring prior to reaction of sulfinyl imine with the sulfur ylide are S, R, and R, respectively. The C—N bond lengths of the aziridine are 1.478 (2) and 1.486 (2) Å

    Young children’s impressionable use of teleology: the influence of question wording and questioned topic on teleological explanations for natural phenomena

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    There is a significant body of research on children's preconceptions concerning scientific concepts and the impact this has upon their science education. One active issue concerns the extent to which young children's explanations for the existence of natural kinds rely on a teleological rationale: for example, rain is for watering the grass, or tigers’ stripes are for camouflage. It has been argued that this teleological tendency hampers children's ability to learn about causality in the natural world. This paper investigates two factors (question wording and topic) which it is argued have led to a misestimation of children's teleological tendencies within the area natural phenomena: i.e., those that are time-constrained, natural events or process such as snow, clouds or night. Sixty-six (5- to 8-years-old) children took part in a repeated-measures experiment, answering both open- and leading-questions across 10 topics of natural phenomena. The findings indicate that children's teleological reasoning may have been overestimated as open question forms significantly reduced their tendency to answer teleologically. Moreover, the concept of teleology is more nuanced than often suggested. Consequently, young children may be more able to learn about causal explanations for the existence of natural phenomena than the literature implies

    Carbohydrate-derived iminium salt organocatalysts for the asymmetric epoxidation of alkenes

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    A new family of carbohydrate-based dihydroisoquinolinium salts has been prepared and tested for potential as asymmetric catalysts for the epoxidation of unfunctionalized alkene substrates, providing up to 57% ee in the product epoxides
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