Cerif for Datasets Final Report

The C4D project (CERIF for Datasets) was funded under the Managing Research Data programme from JISC. This report summarises the project’s activities and achievements during its duration. The partners in the project are the University of Sunderland (lead), the University of Glasgow, the University of St Andrews, EPSRC, NERC and EuroCRIS. This final report reflects input received from all partners

Shaping Metrics for HEI Cultural Engagement - Knowledge Transfer

An application was submitted to the Arts and Humanities Research Council (AHRC) for support for a project that would identify and define activities deemed relevant to Knowledge Transfer (KT) - Cultural Engagement (CE), and propose appropriate means to evaluate them. It was acknowledged from the outset that efforts at agreeing “metrics” for the impact of such activities had been attempted before, albeit with limited success. (One such notable example has been lately provided by the Higher Education and Business Community Interaction Survey (HEBCIS) which has collected some data on social, community, and cultural engagement for some years; however, the robustness and consistency of the data for these purposes have often been questioned.

Yorkshire fairs and markets to the end of the eighteenth century.

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The optical field angle distortion calibration feasibility study for the Hubble Space Telescope fine guidance sensors

The results of an analytical study to investigate the feasibility of calibrating the Hubble Space Telescope's (HST's) fine guidance sensors (FGSs) within HST mission accuracy limits are presented. The study has two purposes: (1) to determine the mathematical feasibility of the optical field angle distortion (OFAD) calibration algorithm and (2) to confirm that the OFAD, plate scale, and FGS-to-FGS alignment calibration algorithms produced a calibration of the FGSs that satisfied mission requirements. The study concluded that the mathematical specification of the OFAD algorithm is adequate and permits a determination of the FGS calibration parameters (accurate to better than 0.003 arc-second) sufficient to meet the mission requirements. The algorithms implemented, the characteristics of the simulated data and procedures for data analysis, and the study's results are discussed. In addition, several useful techniques for improving the stability and accuracy of the OFAD solution are outlined

Darnella

None of these poems have been previously publishe

Cerif for Datasets Final Report

The C4D project (CERIF for Datasets) was funded under the Managing Research Data programme from JISC. This report summarises the project’s activities and achievements during its duration. The partners in the project are the University of Sunderland (lead), the University of Glasgow, the University of St Andrews, EPSRC, NERC and EuroCRIS. This final report reflects input received from all partners

Shaping Metrics for HEI Cultural Engagement - Knowledge Transfer

An application was submitted to the Arts and Humanities Research Council (AHRC) for support for a project that would identify and define activities deemed relevant to Knowledge Transfer (KT) - Cultural Engagement (CE), and propose appropriate means to evaluate them. It was acknowledged from the outset that efforts at agreeing “metrics” for the impact of such activities had been attempted before, albeit with limited success. (One such notable example has been lately provided by the Higher Education and Business Community Interaction Survey (HEBCIS) which has collected some data on social, community, and cultural engagement for some years; however, the robustness and consistency of the data for these purposes have often been questioned.

Cognitive impairment in schizophrenia: aetiology, pathophysiology, and treatment

Cognitive deficits are a core feature of schizophrenia, account for much of the impaired functioning associated with the disorder and are not responsive to existing treatments. In this review, we first describe the clinical presentation and natural history of these deficits. We then consider aetiological factors, highlighting how a range of similar genetic and environmental factors are associated with both cognitive function and schizophrenia. We then review the pathophysiological mechanisms thought to underlie cognitive symptoms, including the role of dopamine, cholinergic signalling and the balance between GABAergic interneurons and glutamatergic pyramidal cells. Finally, we review the clinical management of cognitive impairments and candidate novel treatments

Genomic risk for post-traumatic stress disorder in families densely affected with alcohol use disorders

Recent genome-wide association studies (GWAS) have identified genetic markers of post-traumatic stress disorder (PTSD) in civilian and military populations. However, studies have yet to examine the genetics of PTSD while factoring in risk for alcohol dependence, which commonly co-occur. We examined genome-wide associations for DSM-IV PTSD among 4,978 trauma-exposed participants (31% with alcohol dependence, 50% female, 30% African ancestry) from the Collaborative Study on the Genetics of Alcoholism (COGA). We also examined associations of polygenic risk scores (PRS) derived from the Psychiatric Genomics Consortium (PGC)-PTSD Freeze 2 (N = 3533) and Million Veterans Program GWAS of PTSD (N = 5200) with PTSD and substance dependence in COGA, and moderating effects of sex and alcohol dependence. 7.3% of COGA participants met criteria for PTSD, with higher rates in females (10.1%) and those with alcohol dependence (12.3%). No independent loci met genome-wide significance in the PTSD meta-analysis of European (EA) and African ancestry (AA) participants. The PGC-PTSD PRS was associated with increased risk for PTSD (B = 0.126, p \u3c 0.001), alcohol dependence (B = 0.231, p \u3c 0.001), and cocaine dependence (B = 0.086, p \u3c 0.01) in EA individuals. A significant interaction was observed, such that EA individuals with alcohol dependence and higher polygenic risk for PTSD were more likely to have PTSD (B = 0.090, p \u3c 0.01) than those without alcohol dependence. These results further support the importance of examining substance dependence, specifically alcohol dependence, and PTSD together when investigating genetic influence on these disorders