Corner and finger formation in Hele--Shaw flow with kinetic undercooling regularisation

We examine the effect of a kinetic undercooling condition on the evolution of a free boundary in Hele--Shaw flow, in both bubble and channel geometries. We present analytical and numerical evidence that the bubble boundary is unstable and may develop one or more corners in finite time, for both expansion and contraction cases. This loss of regularity is interesting because it occurs regardless of whether the less viscous fluid is displacing the more viscous fluid, or vice versa. We show that small contracting bubbles are described to leading order by a well-studied geometric flow rule. Exact solutions to this asymptotic problem continue past the corner formation until the bubble contracts to a point as a slit in the limit. Lastly, we consider the evolving boundary with kinetic undercooling in a Saffman--Taylor channel geometry. The boundary may either form corners in finite time, or evolve to a single long finger travelling at constant speed, depending on the strength of kinetic undercooling. We demonstrate these two different behaviours numerically. For the travelling finger, we present results of a numerical solution method similar to that used to demonstrate the selection of discrete fingers by surface tension. With kinetic undercooling, a continuum of corner-free travelling fingers exists for any finger width above a critical value, which goes to zero as the kinetic undercooling vanishes. We have not been able to compute the discrete family of analytic solutions, predicted by previous asymptotic analysis, because the numerical scheme cannot distinguish between solutions characterised by analytic fingers and those which are corner-free but non-analytic

Numerical investigation of controlling interfacial instabilities in non-standard Hele-Shaw configurations

Viscous fingering experiments in Hele-Shaw cells lead to striking pattern formations which have been the subject of intense focus among the physics and applied mathematics community for many years. In recent times, much attention has been devoted to devising strategies for controlling such patterns and reducing the growth of the interfacial fingers. We continue this research by reporting on numerical simulations, based on the level set method, of a generalised Hele-Shaw model for which the geometry of the Hele-Shaw cell is altered. First, we investigate how imposing constant and time-dependent injection rates in a Hele-Shaw cell that is either standard, tapered or rotating can be used to reduce the development of viscous fingering when an inviscid fluid is injected into a viscous fluid over a finite time period. We perform a series of numerical experiments comparing the effectiveness of each strategy to determine how these non-standard Hele-Shaw configurations influence the morphological features of the inviscid-viscous fluid interface. Tapering plates in either converging or diverging directions leads to reduced metrics of viscous fingering at the final time when compared to the standard parallel configuration, especially with carefully chosen injection rates; for the rotating plate case, the effect is even more dramatic, with sufficiently large rotation rates completely stabilising the interface. Next, we illustrate how the number of non-splitting fingers can be controlled by injecting the inviscid fluid at a time-dependent rate while increasing the gap between the plates. Simulations compare well with previous experimental results for various injection rates and geometric configurations. Further, we demonstrate how the fully nonlinear dynamics of the problem affect the number of fingers that emerge and how well this number agrees with predictions from linear stability analysis

A novel model for one-dimensional morphoelasticity. Part I - Theoretical foundations

While classical continuum theories of elasticity and viscoelasticity have long been used to describe the mechanical behaviour of solid biological tissues, they are of limited use for the description of biological tissues that undergo continuous remodelling. The structural changes to a soft tissue associated with growth and remodelling require a mathematical theory of ‘morphoelasticity’ that is more akin to plasticity than elasticity. However, previously-derived mathematical models for plasticity are difficult to apply and interpret in the context of growth and remodelling: many important concepts from the theory of plasticity do not have simple analogues in biomechanics.\ud \ud In this work, we describe a novel mathematical model that combines the simplicity and interpretability of classical viscoelastic models with the versatility of plasticity theory. While our focus here is on one-dimensional problems, our model builds on earlier work based on the multiplicative decomposition of the deformation gradient and can be adapted to develop a three-dimensional theory. The foundation of this work is the concept of ‘effective strain’, a measure of the difference between the current state and a hypothetical state where the tissue is mechanically relaxed. We develop one-dimensional equations for the evolution of effective strain, and discuss a number of potential applications of this theory. One significant application is the description of a contracting fibroblast-populated collagen lattice, which we further investigate in Part II

A novel model for one-dimensional morphoelasticity. Part II - Application to the contraction of fibroblast-populated collagen lattices

Fibroblast-populated collagen lattices are commonly used in experiments to study the interplay between fibroblasts and their pliable environment. Depending on the method by which\ud they are set, these lattices can contract significantly, in some cases contracting to as little as 10% of their initial lateral (or vertical) extent. When the reorganisation of such lattices by fibroblasts is interrupted, it has been observed that the gels re-expand slightly but do not return to their original size. In order to describe these phenomena, we apply our theory of one-dimensional morphoelasticity derived in Part I to obtain a system of coupled ordinary differential equations, which we use to describe the behaviour of a fibroblast-populated collagen lattice that is tethered by a spring of known stiffness. We obtain approximate solutions that describe the behaviour of the system at short times as well as those that are valid for long times. We also obtain an exact description of the behaviour of the system in the case where the lattice reorganisation is interrupted. In addition, we perform a perturbation analysis in the limit of large spring stiffness to obtain inner and outer asymptotic expansions for the solution, and examine the relation between force and traction stress in this limit. Finally, we compare predicted numerical values for the initial stiffness and viscosity of the gel with corresponding values for previously obtained sets of experimental data and also compare the qualitative behaviour with that of our model in each case. We find that our model captures many features of the observed behaviour of fibroblast-populated collagen lattices

Saffman-Taylor fingers with kinetic undercooling

The mathematical model of a steadily propagating Saffman-Taylor finger in a Hele-Shaw channel has applications to two-dimensional interacting streamer discharges which are aligned in a periodic array. In the streamer context, the relevant regularisation on the interface is not provided by surface tension, but instead has been postulated to involve a mechanism equivalent to kinetic undercooling, which acts to penalise high velocities and prevent blow-up of the unregularised solution. Previous asymptotic results for the Hele-Shaw finger problem with kinetic undercooling suggest that for a given value of the kinetic undercooling parameter, there is a discrete set of possible finger shapes, each analytic at the nose and occupying a different fraction of the channel width. In the limit in which the kinetic undercooling parameter vanishes, the fraction for each family approaches 1/2, suggesting that this 'selection' of 1/2 by kinetic undercooling is qualitatively similar to the well-known analogue with surface tension. We treat the numerical problem of computing these Saffman-Taylor fingers with kinetic undercooling, which turns out to be more subtle than the analogue with surface tension, since kinetic undercooling permits finger shapes which are corner-free but not analytic. We provide numerical evidence for the selection mechanism by setting up a problem with both kinetic undercooling and surface tension, and numerically taking the limit that the surface tension vanishes.Comment: 10 pages, 6 figures, accepted for publication by Physical Review

A two-compartment mechanochemical model of the roles of\ud transforming growth factor β and tissue tension in dermal wound healing

The repair of dermal tissue is a complex process of interconnected phenomena, where cellular, chemical and mechanical aspects all play a role, both in an autocrine and in a paracrine fashion. Recent experimental results have shown that transforming growth factor−β (TGFβ) and tissue mechanics play roles in regulating cell proliferation, differentiation and the production of extracellular materials. We have developed a 1D mathematical model that considers the interaction between the cellular, chemical and mechanical phenomena, allowing the combination of TGFβ and tissue stress to inform the activation of fibroblasts to myofibroblasts. Additionally, our model incorporates the observed feature of residual stress by considering the changing zero-stress state in the formulation for effective strain. Using this model, we predict that the continued presence of TGFβ in dermal wounds will produce contractures due to the persistence of myofibroblasts; in contrast, early elimination of TGFβ significantly reduces the myofibroblast numbers resulting in an increase in wound size. Similar results were obtained by varying the rate at which fibroblasts differentiate to myofibroblasts and by changing the myofibroblast apoptotic rate. Taken together, the implication is that elevated levels of myofibroblasts is the key factor behind wounds healing with excessive contraction, suggesting that clinical strategies which aim to reduce the myofibroblast density may reduce the appearance of contractures

Differential Synchronization in Default and Task-Specific Networks of the Human Brain

On a regional scale the brain is organized into dynamic functional networks. The activity within one of these, the default network, can be dissociated from that in other task-specific networks. All brain networks are connected structurally but evidently are only transiently connected functionally. One hypothesis as to how such transient functional coupling occurs is that network formation and dissolution is mediated by increases and decreases in oscillatory synchronization between constituent brain regions. If so, then we should be able to find transient differences in intra-network synchronization between the default network and a task-specific network. In order to investigate this hypothesis we conducted two experiments in which subjects engaged in a Sustained Attention to Response Task while having brain activity recorded via high-density electroencephalography (EEG). We found that during periods when attention was focused internally (mind wandering) there was significantly more neural phase synchronization between brain regions associated with the default network, whereas during periods when subjects were focused on performing the visual task there was significantly more neural phase synchrony within a task-specific brain network that shared some of the same brain regions. These differences in network synchrony occurred in each of theta, alpha, and gamma frequency bands. A similar pattern of differential oscillatory power changes, indicating modulation of local synchronization by attention state, was also found. These results provide further evidence that the human brain is intrinsically organized into default and task-specific brain networks, and confirm that oscillatory synchronization is a potential mechanism for functional coupling within these networks

A fibrocontractive mechanochemical model of dermal wound\ud closure incorporating realistic growth factor kinetics

Fibroblasts and their activated phenotype, myofibroblasts, are the primary cell types involved in the contraction associated with dermal wound healing. Recent experimental evidence indicates that the transformation from fibroblasts to myofibroblasts involves two distinct processes: the cells are stimulated to change phenotype by the combined actions of transforming growth factor β (TGFβ) and mechanical tension. This observation indicates a need for a detailed exploration of the effect of the strong interactions between the mechanical changes and growth factors in dermal wound healing. We review the experimental findings in detail and develop a model of dermal wound healing that incorporates these phenomena. Our model includes the interactions between TGFβ and collagenase, providing a more biologically realistic form for the growth factor kinetics than those included in previous mechanochemical descriptions. A comparison is made between the model predictions and experimental data on human dermal wound healing and all the essential features are well matched

Interfacial dynamics and pinch-off singularities for axially symmetric Darcy flow

We study a model for the evolution of an axially symmetric bubble of inviscid fluid in a homogeneous porous medium otherwise saturated with a viscous fluid. The model is a moving boundary problem that is a higher-dimensional analogue of Hele-Shaw flow. Here we are concerned with the development of pinch-off singularities characterised by a blow-up of the interface curvature and the bubble subsequently breaking up into two; these singularities do not occur in the corresponding two-dimensional Hele-Shaw problem. By applying a novel numerical scheme based on the level set method, we show that solutions to our problem can undergo pinch-off in various geometries. A similarity analysis suggests that the minimum radius behaves as a power law in time with exponent $\alpha = 1/3$ just before and after pinch-off has occurred, regardless of the initial conditions; our numerical results support this prediction. Further, we apply our numerical scheme to simulate the time-dependent development and translation of axially symmetric Saffman-Taylor fingers and Taylor-Saffman bubbles in a cylindrical tube, highlighting key similarities and differences with the well-studied two-dimensional cases.Comment: 16 pages, 16 figure