Bipolar disorder and neurophysiologic mechanisms

Recent studies have suggested that some variants of bipolar disorder (BD) may be due to hyperconnectivity between orbitofrontal (OFC) and temporal pole (TP) structures in the dominant hemisphere. Some initial MRI studies noticed that there were corpus callosum abnormalities within specific regional areas and it was hypothesized that developmentally this could result in functional or effective connectivity changes within the orbitofrontal-basal ganglia-thalamocortical circuits. Recent diffusion tensor imaging (DTI) white matter fiber tractography studies may well be superior to region of interest (ROI) DTI in understanding BD. A “ventral semantic stream” has been discovered connecting the TP and OFC through the uncinate and inferior longitudinal fasciculi and the elusive TP is known to be involved in theory of mind and complex narrative understanding tasks. The OFC is involved in abstract valuation in goal and sub-goal structures and the TP may be critical in binding semantic memory with person–emotion linkages associated with narrative. BD patients have relative attenuation of performance on visuoconstructional praxis consistent with an atypical localization of cognitive functions. Multiple lines of evidence suggest that some BD alleles are being selected for which could explain the enhanced creativity in higher-ability probands. Associations between ROI’s that are not normally connected could explain the higher incidence of artistic aptitude, writing ability, and scientific achievements among some mood disorder subjects

Interference between a large number of independent Bose-Einstein condensates

We study theoretically the interference patterns produced by the overlap of an array of Bose-Einstein condensates that have no phase coherence among them. We show that density-density correlations at different quasimomenta, which play an important role in two-condensate interference, become negligible for large $N$, where $N$ is the number of overlapping condensates. In order to understand the physics of this phenomenon, it is sufficient to consider the periodicity of the lattice and the statistical probability distribution of a random-walk problem. The average visibility of such interference patterns decreases as $N^{-1/2}$ for large $N$.Comment: 9 pages, 2 figure

Developing guidelines for the human-wildlife interactions in conservation translocations

Workshop: Conservation translocation is a widely used management intervention to restore locally extinct or augment severely depleted species. Human dimension issues that influence the achievement of these aims are encountered at five different stages of the project life cycle: 1) Planning, 2) Initiation, 3) Implementation, 4) Ending, and 5) Post-exit stage. Overlooking such dimension may jeopardise the success of the project. Understanding and addressing human-wildlife interaction issues improve community involvement, peers’ acceptance and the support from various interest groups. In this workshop we propose to discuss participants’ experiences in human dimensions related to each of the 5 stages of a project’s life cycle.  Discussions aims to expand on findings from the IUCN/SSC CTSG HWIWG 2022 Guidelines to Facilitate Human-Wildlife Interactions in Conservation Translocations, to identify best practice and key issues for each stage to inform planning and promote wildlife conservation, collaboration amongst groups and coexistence

Community Service to the Elderly A Service-Learning Model: Guidelines for Replication

At the University of Pittsburgh, Generations Together, an Intergenerational Studies Program develops programs that bring young and old together in ways that benefit both generations. The University Challenge for Excellence Program (DCEP) works with entering students who are often first generation, mostly African-American, and who may be in need of special assistance during their first year. UCEP seeks ways to raise their self esteem, give them a sense of purpose, connect them to the University, and ultimately to retain them at Pitt through graduation. In 1994, these two university programs joined together with the Housing Authority of the City of Pittsburgh (HACP) to develop a program that addresses the needs of UCEP students and older adults in Pittsburgh. The result of this collaboration is an intergenerational community service project which was funded by the U. S. Department of Education\u27s Fund for the Improvement of Post-Secondary Education (FIPSE)

First exit times and residence times for discrete random walks on finite lattices

In this paper, we derive explicit formulas for the surface averaged first exit time of a discrete random walk on a finite lattice. We consider a wide class of random walks and lattices, including random walks in a non-trivial potential landscape. We also compute quantities of interest for modelling surface reactions and other dynamic processes, such as the residence time in a subvolume, the joint residence time of several particles and the number of hits on a reflecting surface.Comment: 19 pages, 2 figure

Visual Puzzles, Figure Weights, and Cancellation: Some Preliminary Hypotheses on the Functional and Neural Substrates of These Three New WAIS-IV Subtests

In this study, five consecutive patients with focal strokes and/or cortical excisions were examined with the Wechsler Adult Intelligence Scale and Wechsler Memory Scale—Fourth Editions along with a comprehensive battery of other neuropsychological tasks. All five of the lesions were large and typically involved frontal, temporal, and/or parietal lobes and were lateralized to one hemisphere. The clinical case method was used to determine the cognitive neuropsychological correlates of mental rotation (Visual Puzzles), Piagetian balance beam (Figure Weights), and visual search (Cancellation) tasks. The pattern of results on Visual Puzzles and Figure Weights suggested that both subtests involve predominately right frontoparietal networks involved in visual working memory. It appeared that Visual Puzzles could also critically rely on the integrity of the left temporoparietal junction. The left temporoparietal junction could be involved in temporal ordering and integration of local elements into a nonverbal gestalt. In contrast, the Figure Weights task appears to critically involve the right temporoparietal junction involved in numerical magnitude estimation. Cancellation was sensitive to left frontotemporal lesions and not right posterior parietal lesions typical of other visual search tasks. In addition, the Cancellation subtest was sensitive to verbal search strategies and perhaps object-based attention demands, thereby constituting a unique task in comparison with previous visual search tasks