Viscous flow between two sinusoidally deforming curved concentric tubes: Advances in endoscopy

Viscous flow between two sinusoidally deforming curved concentric tubes is mathematically investigated for the first time. Exact solutions are computed to analyse the flow between these two tubes and graphical outcomes are included for a thorough analysis of the solutions. The present article has prime applications in endoscopy as a novel peristaltic endoscope is introduced first time for a curved sinusoidal tube. This curved nature of outer sinusoidal tube with a flexible peristaltic endoscope placed inside it covers the topic of practical applications like endoscopy of human organs having curved shapes and the maintenance of complex machineries that involve complex curve structures. The usage of a flexible peristaltic endoscope inside a curved sinusoidal tube makes the process of catheterization more comfortable

Novel idea about the peristaltic flow of heated Newtonian fluid in elliptic duct having ciliated walls

This novel investigation unfolds the mathematical model of peristaltic flow in an elliptic duct having ciliated walls. The current assessment is carried out by considering a heated Newtonian viscous fluid in this ciliated elliptic duct. A detailed heat transfer study combined with various physical aspects of peristalsis is provided. We have incorporated the appropriate and useful transformations that simplify this mathematical problem into its non-dimensional form with relevant non-dimensional boundary conditions over the surface of ciliated elliptic duct. Finally, the exact mathematical results are computed for this interesting problem. A thorough graphical assessment is also included for a complete understanding of mathematical results. The axially symmetric flow behaviour is noted for both velocity and temperature profiles in this elliptic duct having ciliated walls

WR1065 mitigates AZT-ddI-induced mutagenesis and inhibits viral replication

The success of nucleoside reverse transcriptase inhibitors (NRTIs) in treating HIV-1 infection and reducing mother-to-child transmission of the virus during pregnancy is accompanied by evidence that NRTIs cause long-term health risks for cancer and mitochondrial disease. Thus, agents that mitigate toxicities of the current combination drug therapies are needed. Previous work had shown that the NRTI-drug pair zidovudine (AZT)–didanosine (ddI) was highly cytotoxic and mutagenic; thus, we conducted preliminary studies to investigate the ability of the active moiety of amifostine, WR1065, to protect against the deleterious effects of this NRTI-drug pair. In TK6 cells exposed to 100 μM AZT-ddI (equimolar) for 3 days with or without 150 μM WR1065, WR1065 enhanced long-term cell survival and significantly reduced AZT-ddI-induced mutations. Follow-up studies were conducted to determine if coexposure to AZT and WR1065 abrogated the antiretroviral efficacy of AZT. In human T-cell blasts infected with HIV-1 in culture, inhibition of p24 protein production was observed in cells treated with 10 μM AZT in the absence or presence of 5–1,000 μM WR1065. Surprisingly, WR1065 alone exhibited dose-related inhibition of HIV-1 p24 protein production. WR1065 also had antiviral efficacy against three species of adenovirus and influenza A and B. Intracellular levels of unbound WR1065 were measured following in vitro/in vivo drug exposure. These pilot study results indicate that WR1065, at low intracellular levels, has cytoprotective and antimutagenic activities against the most mutagenic pair of NRTIs and has broad spectrum anti-viral effects. These findings suggest that the activities have a possible common mode of action that merits further investigation