On the Intracluster Medium in Cooling Flow & Non-Cooling Flow Clusters

Recent X-ray observations have highlighted clusters that lack entropy cores. At first glance, these results appear to invalidate the preheated ICM models. We show that a self-consistent preheating model, which factors in the effects of radiative cooling, is in excellent agreement with the observations. Moreover, the model naturally explains the intrinsic scatter in the L-T relation, with ``cooling flow'' and ``non-cooling flow'' systems corresponding to mildly and strongly preheated systems, respectively. We discuss why preheating ought to be favoured over merging as a mechanism for the origin of ``non-cooling flow'' clusters.Comment: 4 pages, to appear in the proceedings of the "Multiwavelength Cosmology" Conference held in Mykonos, Greece, June 2003, ed. M. Plionis (Kluwer

Explaining Political Violence Against Civilians in Northern Ireland: A Contention-Oriented Approach

In contrast to prevalent theories of terrorism, this study develops a contention-oriented approach where levels and forms of political violence against civilians depend upon: (1) the strategies of combatants; (2) the means of contention; (3) the locations of allies and opponents; (4) the collective identities of combatants; and (5) the dynamics of contention, including whether or not representatives of paramilitary organizations are included in formal peace processes. Quantitative analyses of a multi-source database of civilian deaths taking place in Northern Ireland between 1966 and 2006 offer preliminary support for this approach. The study underscores the insights provided by theories and methods used in the fields of social movements research and peace and conflict studies

Supersymmetry and gauge theory on Calabi-Yau 3-folds

We consider the dimensional reduction of supersymmetric Yang-Mills on a Calabi-Yau 3-fold. We show by construction how the resulting cohomological theory is related to the balanced field theory of the Kaehler Yang-Mills equations introduced by Donaldson and Uhlenbeck-Yau.Comment: 11 page

Striatal cholinergic interneurons generate beta and gamma oscillations in the corticostriatal circuit and produce motor deficits

Cortico-basal ganglia-thalamic (CBT) neural circuits are critical modulators of cognitive and motor function. When compromised, these circuits contribute to neurological and psychiatric disorders, such as Parkinson's disease (PD). In PD, motor deficits correlate with the emergence of exaggerated beta frequency (15-30 Hz) oscillations throughout the CBT network. However, little is known about how specific cell types within individual CBT brain regions support the generation, propagation, and interaction of oscillatory dynamics throughout the CBT circuit or how specific oscillatory dynamics are related to motor function. Here, we investigated the role of striatal cholinergic interneurons (SChIs) in generating beta and gamma oscillations in cortical-striatal circuits and in influencing movement behavior. We found that selective stimulation of SChIs via optogenetics in normal mice robustly and reversibly amplified beta and gamma oscillations that are supported by distinct mechanisms within striatal-cortical circuits. Whereas beta oscillations are supported robustly in the striatum and all layers of primary motor cortex (M1) through a muscarinic-receptor mediated mechanism, gamma oscillations are largely restricted to the striatum and the deeper layers of M1. Finally, SChI activation led to parkinsonian-like motor deficits in otherwise normal mice. These results highlight the important role of striatal cholinergic interneurons in supporting oscillations in the CBT network that are closely related to movement and parkinsonian motor symptoms.DP2 NS082126 - NINDS NIH HHS; R01 NS081716 - NINDS NIH HHS; R21 NS078660 - NINDS NIH HHShttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4896681/Published versio

The meniscus, calcification and osteoarthritis: a pathologic team.

Articular calcification correlates with osteoarthritis (OA) severity but its exact role in the disease process is unclear. In examining OA meniscal cell function, Sun and colleagues have shown recently that meniscal cells from end-stage OA subjects can generate calcium crystals and that genes involved in calcification are upregulated in OA meniscal cells. Also, this in vitro calcium deposition by OA menisci is inhibited by phosphocitrate. This study should catalyse further work examining the pathological contribution or otherwise of calcium crystals in OA. This would significantly aid the development of potential disease modifying agents in OA, which are currently unavailable

Models of the ICM with Heating and Cooling: Explaining the Global and Structural X-ray Properties of Clusters

(Abridged) Theoretical models that include only gravitationally-driven processes fail to match the observed mean X-ray properties of clusters. As a result, there has recently been increased interest in models in which either radiative cooling or entropy injection play a central role in mediating the properties of the intracluster medium. Both sets of models give reasonable fits to the mean properties of clusters, but cooling only models result in fractions of cold baryons in excess of observationally established limits and the simplest entropy injection models do not treat the "cooling core" structure present in many clusters and cannot account for entropy profiles revealed by recent X-ray observations. We consider models that marry radiative cooling with entropy injection, and confront model predictions for the global and structural properties of massive clusters with the latest X-ray data. The models successfully and simultaneously reproduce the observed L-T and L-M relations, yield detailed entropy, surface brightness, and temperature profiles in excellent agreement with observations, and predict a cooled gas fraction that is consistent with observational constraints. The model also provides a possible explanation for the significant intrinsic scatter present in the L-T and L-M relations and provides a natural way of distinguishing between clusters classically identified as "cooling flow" clusters and dynamically relaxed "non-cooling flow" clusters. The former correspond to systems that had only mild levels (< 300 keV cm^2) of entropy injection, while the latter are identified as systems that had much higher entropy injection. This is borne out by the entropy profiles derived from Chandra and XMM-Newton.Comment: 20 pages, 15 figures, accepted for publication in the Astrophysical Journa