The Ethics of Irony in Kierkegaard

The Ethics of Irony in Kierkegaar

Childcare, choice and social class: Caring for young children in the UK

This paper draws on the results of two qualitative research projects examining parental engagements with the childcare market in the UK. Both projects are located in the same two London localities. One project focuses on professional middle class parents, and the other on working class families, and we discuss the key importance of social class in shaping parents' differential engagement with the childcare market, and their understandings of the role childcare plays in their children's lives. We identify and discuss the different "circuits" of care (Ball et al 1995) available to and used by families living physically close to each other, but in social class terms living in different worlds. We also consider parents' relationships with carers, and their social networks. We conclude that in order to fully understand childcare policies and practices and families' experiences of care, an analysis which encompasses social class and the workings of the childcare market is needed

The baryon fraction of LambdaCDM haloes

We investigate the baryon fraction in dark matter haloes formed in non-radiative gas-dynamical simulations of the LambdaCDM cosmogony. By combining a realisation of the Millennium Simulation (Springel et al.) with a simulation of a smaller volume focussing on dwarf haloes, our study spans five decades in halo mass, from 10^10 Msun/h to 10^15 Msun/h. We find that the baryon fraction within the halo virial radius is typically 90% of the cosmic mean, with an rms scatter of 6%, independently of redshift and of halo mass down to the smallest resolved haloes. Our results show that, contrary to the proposal of Mo et al. (2005), pre-virialisation gravitational heating is unable to prevent the collapse of gas within galactic and proto-galactic haloes, and confirm the need for non-gravitational feedback in order to reduce the efficiency of gas cooling and star formation in dwarf galaxy haloes. Simulations including a simple photoheating model (where a gas temperature floor of T_{floor} = 2x10^4 K is imposed from z=11) confirm earlier suggestions that photoheating can only prevent the collapse of baryons in systems with virial temperatures T_{200} < ~2.2 T_{floor} ~ 4.4x10^4 K (corresponding to a virial mass of M_{200} ~ 10^10 Msun/h and a circular velocity of V_{200} ~ 35 km/s). Photoheating may thus help regulate the formation of dwarf spheroidals and other galaxies at the extreme faint-end of the luminosity function, but it cannot, on its own, reconcile the abundance of sub-L* galaxies with the vast number of dwarf haloes expected in the LambdaCDM cosmogony. The lack of evolution or mass dependence seen in the baryon fraction augurs well for X-ray cluster studies that assume a universal and non-evolving baryon fraction to place constraints on cosmological parameters.Comment: 9 pages, 5 figures (Figs 1. and 2 reduced in quality), 1 table, submitted to MNRAS. Version with high-resolution figures can be obtained from http://star-www.dur.ac.uk/~rcrain/baryonfractions

The digital mirror Langmuir probe: Field programmable gate array implementation of real-time Langmuir probe biasing

High bandwidth, high spatial resolution measurements of electron temperature, density, and plasma potential are valuable for resolving turbulence in the boundary plasma of tokamaks. While conventional Langmuir probes can provide such measurements, either their temporal or spatial resolution is limited: the former by the sweep rate necessary for obtaining I-V characteristics and the latter by the need to use multiple electrodes, as is the case in triple and double probe configurations. The Mirror Langmuir Probe (MLP) bias technique overcomes these limitations by rapidly switching the voltage on a single electrode cycling between three bias states, each dynamically optimized for the local plasma conditions. The MLP system on Alcator C-Mod used analog circuitry to perform this function, measuring Te, VF, and Isat at 1.1 MSPS. Recently, a new prototype digital MLP controller has been implemented on a Red Pitaya Field Programmable Gate Array (FPGA) board which reproduces the functionality of the original controller and performs all data acquisition. There is also the potential to provide the plasma parameters externally for use with feedback control systems. The use of FPGA technology means the system is readily customizable at a fraction of the development time and implementation cost. A second Red Pitaya was used to test the MLP by simulating the current response of a physical probe using C-Mod experimental measurements. This project is available as a git repository to facilitate extensibility (e.g., real-time control outputs and more voltage states) and scalability through collaboration

Heart failure following blood cancer therapy in pediatric and adult populations

Aim: The link between chemotherapy treatment and cardiotoxicity is well established, particularly for adults with blood cancers. However, it is less clear for children. This analysis aimed to compare the trajectory and mortality of children and adults who received chemotherapy for blood cancers and were subsequently hospitalised for heart failure. Methods: Linked data from the Queensland Cancer Registry, Death Registry and Hospital Administration records for initial chemotherapy and later heart failure were reviewed (1996-2009). Of all identified blood cancer patients (N=23,434); 8,339 received chemotherapy, including 817 children (aged ≤18 years at time of cancer diagnosis) and 7,522 adults. Time-varying Cox proportional hazards regression models were used to compare the characteristics and survival between the two groups. Results: Of those who were subsequently hospitalised for heart failure, 70% of children and 46% of adults had the index admission within 12 months of their cancer diagnosis. Of these, 53% of the pediatric heart failure population and 71% of the adult heart failure population died within the study period. Following adjustment for age, sex and chemotherapy admissions, children with heart failure had an increased mortality risk compared to their non-heart failure counterparts, a difference which was much greater than that between the adult groups. Conclusion: The impact of heart failure on children previously treated for blood cancer is more severe than for adults, with earlier morbidity and greater mortality. Improved strategies are needed for the prevention and management of cardiotoxicity in this population

The M Dwarf Problem in the Galaxy

We present evidence that there is an M dwarf problem similar to the previously identified G dwarf and K dwarf problems: the number of low-metallicity M dwarfs is not sufficient to match simple closed-box models of local Galactic chemical evolution. We estimated the metallicity of 4141 M dwarf stars with spectra from the Sloan Digital Sky Survey (SDSS) using a molecular band strength versus metallicity calibration developed using high resolution spectra of nearby M dwarfs. Using a sample of M dwarfs with measured magnitudes, parallaxes, and metallicities, we derived a relation that describes the absolute magnitude variation as a function of metallicity. When we examined the metallicity distribution of SDSS stars, after correcting for the different volumes sampled by the magnitude-limited survey, we found that there is an M dwarf problem, with the number of M dwarfs at [Fe/H] ~ -0.5 less than 1% the number at [Fe/H] = 0, where a simple model of Galactic chemical evolution predicts a more gradual drop in star numbers with decreasing metallicity.Comment: To be published in Monthly Notices of the RAS by the Royal Astronomical Society and Blackwell Publishing. 7 pages, 3 figure

The Physical Origins of The Morphology-Density Relation: Evidence for Gas Stripping from the SDSS

We provide a physical interpretation and explanation of the morphology-density relation for galaxies, drawing on stellar masses, star formation rates, axis ratios and group halo masses from the Sloan Digital Sky Survey. We first re-cast the classical morphology-density relation in more quantitative terms, using low star formation rate (quiescence) as a proxy for early-type morphology and dark matter halo mass from a group catalog as a proxy for environmental density: for galaxies of a given stellar mass the quiescent fraction is found to increase with increasing dark matter halo mass. Our novel result is that - at a given stellar mass - quiescent galaxies are significantly flatter in dense environments, implying a higher fraction of disk galaxies. Supposing that the denser environments differ simply by a higher incidence of quiescent disk galaxies that are structurally similar to star-forming disk galaxies of similar mass, explains simultaneously and quantitatively these quiescence -nvironment and shape-environment relations. Our findings add considerable weight to the slow removal of gas as the main physical driver of the morphology-density relation, at the expense of other explanations.Comment: published in ApJ: http://adsabs.harvard.edu/abs/2010ApJ...714.1779

Statistical independence of the colocalized association signals for type 1 diabetes and RPS26 gene expression on chromosome 12q13

Following the recent success of genome-wide association studies in uncovering disease-associated genetic variants, the next challenge is to understand how these variants affect downstream pathways. The most proximal trait to a disease-associated variant, most commonly a single nucleotide polymorphism (SNP), is differential gene expression due to the cis effect of SNP alleles on transcription, translation, and/or splicing gene expression quantitative trait loci (eQTL). Several genome-wide SNP–gene expression association studies have already provided convincing evidence of widespread association of eQTLs. As a consequence, some eQTL associations are found in the same genomic region as a disease variant, either as a coincidence or a causal relationship. Cis-regulation of RPS26 gene expression and a type 1 diabetes (T1D) susceptibility locus have been colocalized to the 12q13 genomic region. A recent study has also suggested RPS26 as the most likely susceptibility gene for T1D in this genomic region. However, it is still not clear whether this colocalization is the result of chance alone or if RPS26 expression is directly correlated with T1D susceptibility, and therefore, potentially causal. Here, we derive and apply a statistical test of this hypothesis. We conclude that RPS26 expression is unlikely to be the molecular trait responsible for T1D susceptibility at this locus, at least not in a direct, linear connection

A multilevel neo-institutional analysis of infection prevention and control in English hospitals: coerced safety culture change?

Despite committed policy, regulative and professional efforts on healthcare safety, little is known about how such macro-interventions permeate organisations and shape culture over time. Informed by neo-institutional theory, we examined how inter-organisational influences shaped safety practices and inter-subjective meanings following efforts for coerced culture change. We traced macro-influences from 2000 to 2015 in infection prevention and control (IPC). Safety perceptions and meanings were inductively analysed from 130 in-depth qualitative interviews with senior- and middle-level managers from 30 English hospitals. A total of 869 institutional interventions were identified; 69% had a regulative component. In this context of forced implementation of safety practices, staff experienced inherent tensions concerning the scope of safety, their ability to be open and prioritisation of external mandates over local need. These tensions stemmed from conflicts among three co-existing institutional logics prevalent in the NHS. In response to requests for change, staff flexibly drew from a repertoire of cognitive, material and symbolic resources within and outside their organisations. They crafted 'strategies of action', guided by a situated assessment of first-hand practice experiences complementing collective evaluations of interventions such as 'pragmatic', 'sensible' and also 'legitimate'. Macro-institutional forces exerted influence either directly on individuals or indirectly by enriching the organisational cultural repertoire

Pion interaction with the trinucleon up to the eta production threshold

Pion elastic, charge exchange scattering and induced eta production on the trinucleon systems are investigated in a coupled-channels approach in momentum space with Fadeev wave functions. The channel $\pi N \rightarrow \eta N$ is included using an isobar model with S-, P-, and D-wave resonances. While the coherent reactions like $^3$He($\pi,\pi)^3$He can be reasonably well reproduced up to $T_{\pi}$=500 MeV, large discrepancies appear for the incoherent processes, $^3$He($\pi^-,\pi^0)^3$H and $^3$He($\pi^-,\eta)^3$H at backward angles and energies above $\Delta$-resonance. In the forward direction the $(\pi,\eta)$ calculations underestimate the experimental measurements very close to threshold but agreement with the data improves with increasing pion energy. Predictions are made for the asymmetries of the various reactions on polarized $^3$He.Comment: 40 pages, 12 figures (available from the authors), Mainz preprint MKPH-T-92-1