36 research outputs found

    Phase I trial of CYT997, a novel cytotoxic and vascular-disrupting agent

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    BACKGROUND: CYT997 is a novel microtubule inhibitor and vascular-disrupting agent with marked preclinical anti-tumour activity. METHODS: This phase I dose-escalation study assessed the safety, tolerability, pharmacokinetics and pharmacodynamics of CYT997 administered by continuous intravenous infusion over 24 h every 3 weeks to patients with advanced solid tumours

    North, south: changing directions in cardiovascular epidemiology (Editorial)

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