Cotton taxes, 1867

https://egrove.olemiss.edu/aldrichcorr_d/1134/thumbnail.jp

Receipt, Property tax, 25 January 1859

https://egrove.olemiss.edu/aldrichcorr_c/1185/thumbnail.jp

Cotton taxes, 1867

https://egrove.olemiss.edu/aldrichcorr_d/1135/thumbnail.jp

Schmidt hammer and terrestrial laser scanning (TLS) used to detect single‐event displacements on the Pleasant Valley fault (Nevada, USA)

Changes in surface roughness on carbonate fault scarps often reflect varying durations of subaerial weathering. On the Pleasant Valley fault in central Nevada, the documentation of a surface rupture in 1915, a long recurrence interval of faulting, slow weathering rate, and a relatively high (2–3 m) single‐event displacement make the discrimination of the historical and penultimate slip patches unambiguous. Following from a 2018 study, we used a Schmidt hammer and terrestrial laser scanning (TLS) to further test whether these weathering patterns delineate exposed slip patches on a fault scarp. Results show that Schmidt hammer rebound value ranges (termed ΔR – the difference between minimum and maximum R‐values in repeat impacts at a point), increase by ~8–10 points across the historical–penultimate event transition zone in two separate scarp transects. TLS‐derived surface roughness also indicates a clear difference between the most recent and penultimate events. The average single‐event displacement (SED) estimated using the Schmidt hammer and TLS is 2.85 m at two transect sites and is roughly equivalent to the visually estimated 3 m. While this fault is an ideal case where we know some of the slip history, the results demonstrate that these techniques show promise for discriminating slip patches on larger carbonate fault scarps with longer paleoearthquake histories, and could be used alongside 36Cl cosmogenic exposure‐age dating to improve paleoseismic records on normal faults. © 2019 John Wiley & Sons, Ltd.The Schmidt hammer and terrestrial laser scanning (TLS) can detect hardness and mm‐ to cm‐scale surface roughness changes on bedrock fault scarps. Here, we demonstrate that these changes occur between the ‘slip patches’ of a 1915 and pre‐1915 event on the Pleasant Valley fault, yielding single event displacements of ~2‐3 m. These techniques can now be combined to estimate SEDs on larger fault scarps with longer records of paleoearthquakes.Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/154454/1/esp4748.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/154454/2/esp4748_am.pd

Delineating the role of βIV-Tubulins in pancreatic cancer: βIVb-tubulin inhibition sensitizes pancreatic cancer cells to vinca alkaloids

Pancreatic cancer (PC) is a lethal disease which is characterized by chemoresistance. Components of the cell cytoskeleton are therapeutic targets in cancer. βIV-tubulin is one such component that has two isotypes—βIVa and βIVb. βIVa and βIVb isotypes only differ in two amino acids at their C-terminus. Studies have implicated βIVa-tubulin or βIVb-tubulin expression with chemoresistance in prostate, breast, ovarian and lung cancer. However, no studies have examined the role of βIV-tubulin in PC or attempted to identify isotype specific roles in regulating cancer cell growth and chemosensitivity. We aimed to determine the role of βIVa- or βIVb-tubulin on PC growth and chemosensitivity. PC cells (MiaPaCa-2, HPAF-II, AsPC1) were treated with siRNA (control, βIVa-tubulin or βIVb-tubulin). The ability of PC cells to form colonies in the presence or absence of chemotherapy was measured by clonogenic assays. Inhibition of βIVa-tubulin in PC cells had no effect chemosensitivity. In contrast, inhibition of βIVb-tubulin in PC cells sensitized to vinca alkaloids (Vincristine, Vinorelbine and Vinblastine), which was accompanied by increased apoptosis and enhanced cell cycle arrest. We show for the first time that βIVb-tubulin, but not βIVa-tubulin, plays a role in regulating vinca alkaloid chemosensitivity in PC cells. The results from this study suggest βIVb-tubulin may be a novel therapeutic target and predictor of vinca alkaloid sensitivity for PC and warrants further investigation

Wave and Tidal Controls on Embayment Circulation and Headland Bypassing for an Exposed, Macrotidal Site

Headland bypassing is the transport of sediment around rocky headlands by wave and tidal action, associated with high-energy conditions and embayment circulation (e.g., mega-rips). Bypassing may be a key component in the sediment budget of many coastal cells, the quantification of which is required to predict the coastal response to extreme events and future coastal change. Waves, currents, and water levels were measured off the headland of a sandy, exposed, and macrotidal beach in 18-m and 26-m depths for 2 months. The observations were used to validate a Delft3D morphodynamic model, which was subsequently run for a wide range of scenarios. Three modes of bypassing were determined: (i) tidally-dominated control during low–moderate wave conditions [flux O (0–102 m3 day−1)]; (ii) combined tidal- and embayment circulation controls during moderate–high waves [O (103 m3 day−1)]; and (iii) multi-embayment circulation control during extreme waves [O (104 m3 day−1)]. A site-specific bypass parameter is introduced, which accurately (R2 = 0.95) matches the modelled bypass rates. A 5-year hindcast predicts bypassing is an order of magnitude less than observed cross-shore fluxes during extreme events, suggesting that bypassing at this site is insignificant at annual timescales. This work serves a starting point to generalise the prediction of headland bypassing

Clean-Fuel e-VTOL Air Mobility Vehicles for Unmanned and Manned Operations

Imagine for a moment, having your very own safe, affordable, clean-fuel, point-to-any point vehicle for travel in the 21st-century 3-dimensional airspace system. Your ultra-reliable e-VTOL allows commuters to leave behind the constraints of hub-and-spoke airports, and the congestion of interstates, turnpikes and freeways. Facilitating Inter- and Intra-urban travel, such as downtown-to-airport, or metropolis-to-metropolis, or home-to-work. Perfect for dense urban environments worldwide. And all while offering the clean power of hydrogen for zero-emission travel. This vision for efficient, clean, delay-free mobility has been talked about for decades, but always waived aside as some kind of futurist vision. This future requires tackling hard problems in propulsion, airspace management, regulatory satisfaction and (not the least) technologies that seemed out of reach. Well, the future is upon us. What’s at stake? Serious impact on climate change. Affordable transportation. Widely available medical-flights. Timely disaster relief and recovery. Autonomous transport and delivery. On-Demand air taxis. Efficient emergency response. Ubiquitous border security. Economical bulk commodity deliveries. Simplified off-shore deliveries. Sustainable fleet support. NASA, FAA and industry have been laying the foundations for decades, starting with the NASA AGATE and SATS programs of the 1990’s to 2000’s, and the industrial initiatives in On-Demand Mobility such as DayJet, SATSair, LinearAir and many others. Now, some 20 years later, we’re poised to build and deliver e-VTOL, powered by clean, reliable hydrogen fuel cells, operated with more reliable simplified vehicle operations, and in more automated airspace capabilities. This paper summarizes the core strategy, progress and challenges in the certification program for a hydrogen fuel-cell powered e-VTOL having redundant power sources, redundant motors, redundant auto-pilots, and an airframe parachute. The authors believe the implications to operator training for safe and reliable transportation services for the public are central to strategies and industrial vision

Post-Prior discrepancies in CDW-EIS calculations for ion impact ionization fully differential cross sections

In this work we present fully differential cross sections (FDCSs) calculations using post and prior version of CDW--EIS theory for helium single ionization by 100 MeV C$^{6+}$ amu$^{-1}$ and 3.6 MeV amu$^{-1}$ Au$^{24+}$ and Au$^{53+}$ ions. We performed our calculations for different momentum transfer and ejected electron energies. The influence of internuclear potential on the ejected electron spectra is taken into account in all cases. We compare our calculations with absolute experimental measurements. It is shown that prior version calculations give better agreement with experiments in almost all studied cases.Comment: 9 pages, 7 figure