The rhythm of retinoids in the brain

Funded by Biological Sciences Research Council. Grant Numbers: BB/G014272/1, BB/K001043/1Peer reviewedPublisher PD

Speciation in Golden-Plovers, Pluvialis dominica and P. fulva: Evidence from the Breeding Grounds

Two forms of golden-plover have long been considered subspecies, Pluvialisdominica dominica and P. d. fulva. Prior studies have shown differences between forms in breeding distributions, wintering distributions, plumage, morphology, molt, and maturation schedules. We report clear and consistent differences in breeding vocalizations and nesting habitat, and strict assortative mating in areas of sympatry in western Alaska. These results indicate a greater degree of differentiation between the forms than was previously appreciated. They are appropriately treated as separate species and should be referred to under the names Pluvialis dominica, for the American Golden-Plover, and Pluvialis fulva, for the Pacific Golden-Plover

The meninges is a source of retinoic acid for the late-developing hindbrain

One general function for retinoic acid (RA) is pattern organization in the CNS. This regulatory factor has an essential role in spinal cord motor neuron and early posterior hindbrain development. In the anterior CNS, however, there is only a limited number of foci of RA synthesis, and less attention has been placed on regions such as the anterior hindbrain where RA synthesizing enzymes are absent. This study shows that a rich source of RA lies around the hindbrain from the RA synthetic enzyme retinaldehyde dehydrogenase-2 (RALDH2) present in the surrounding meninges and mesenchyme by embryonic day 13. RALDH2 is not distributed uniformly throughout the meninges but is restricted to territories over the developing hindbrain, suggesting that RA signaling may be localized to those regions. Further regulation of RA signaling is provided by the presence of a RA sink in the form of the CYP26B1 RA catabolic enzyme expressed in deeper regions of the brain. As a guide to the neural anatomy of hindbrain RA signaling, we used a mouse transgenic for a lacZ reporter gene driven by a RA response element (RAREhsplacZ) to identify regions of RA signaling. This reporter mouse provides evidence that RA signaling in the hindbrain after embryonic day 13 occurs in the regions of the cerebellum and precerebellar system adjacent to sources of RA, including the inferior olive and the pontine nuclei

Differential retinoic acid signaling in the hippocampus of aged rats with and without memory impairment

Funding Information: This work was entirely supported by the Intramural Research Program of the National Institutes of Health, National institute on Aging.Peer reviewedPublisher PD

Fenretinide Treatment Prevents Diet-Induced Obesity in Association With Major Alterations in Retinoid Homeostatic Gene Expression in Adipose, Liver and Hypothalamus

Peer reviewedPublisher PD

Perturbation of Retinoid Homeostasis Increases Malformation Risk in Embryos Exposed to Pregestational Diabetes

Funding. This work was supported by funding from Hong Kong Research Grants Council General Research Fund project reference 441606 and 474109 to A.S.W.S., Y.C.L., C.C.W., P.J.M. and A.J.C..Peer reviewedPostprin

Математичне програмування

Викладено основи математичного програмування - науки, що займається оптимізаційними методами, які слугують кількісним обґрунтуванням оптимальних управлінських рішень в економіці. Розглянуто основні поняття і методологічні принципи математичного програмування, математичні методи оптимізації (лінійне, дробово-лінійне, цілочислове, нелінійне, динамічне програмування). Матеріал викладено на порівняно елементарному рівні, доступно- му студентам, які знайомі з курсом математики для економістів. Методи, що розглядаються в посібнику, ілюструються великою кількістю прикладів. Посібник має на меті навчити студентів застосовувати математику та обчислювальну техніку для обґрунтування оптимальних економічних рішен

Expression of the retinoic acid catabolic enzyme CYP26B1 in the human brain to maintain signaling homeostasis

Date of Acceptance: 27/08/2015 Funding was provided by the Wellcome Trust grant WT081633MA-NCE and Biological Sciences Research Council Grant BB/K001043/1. Prof Fragoso is the recipient of a Post Doctoral Science without Borders grant from the Brazilian National Council for Scientific and Technological Development (CNPq, 237450/2012-7).Peer reviewedPublisher PD

Bcl-xL regulates mitochondrial energetics by stabilizing the inner membrane potential

To promote cell survival, the antiapoptotic factor Bcl-xL both inhibits Bax-induced mitochondrial outer membrane permeabilization and stabilizes mitochondrial inner membrane ion flux and thus overall mitochondrial energetic capacity