Fermions, T-duality and effective actions for D-branes in bosonic backgrounds

We find the effective action for any D-brane in a general bosonic background of supergravity. The results are explicit in component fields up to second order in the fermions and are obtained in a covariant manner. No interaction terms between fermions and the field $f=b+F$, characteristic of the bosonic actions, are considered. These are reserved for future work. In order to obtain the actions, we reduce directly from the M2-brane world-volume action to the D2-brane world-volume action. Then, by means of T-duality, we obtain the other Dp-brane actions. The resulting Dp-brane actions can be written in a single compact and elegant expression.Comment: 22 pages, latex, version published by JHEP plus typos corrected in eq.(44) and eq.(47

Building the cosmic distance scale: from Hipparcos to Gaia

Hipparcos, the first ever experiment of global astrometry, was launched by ESA in 1989 and its results published in 1997 (Perryman et al., Astron. Astrophys. 323, L49, 1997; Perryman & ESA (eds), The Hipparcos and Tycho catalogues, ESA SP-1200, 1997). A new reduction was later performed using an improved satellite attitude reconstruction leading to an improved accuracy for stars brighter than 9th magnitude (van Leeuwen & Fantino, Astron. Astrophys. 439, 791, 2005; van Leeuwen, Astron. Astrophys. 474, 653, 2007). The Hipparcos Catalogue provided an extended dataset of very accurate astrometric data (positions, trigonometric parallaxes and proper motions), enlarging by two orders of magnitude the quantity and quality of distance determinations and luminosity calibrations. The availability of more than 20000 stars with a trigonometric parallax known to better than 10% opened the way to a drastic revision of our 3-D knowledge of the solar neighbourhood and to a renewal of the calibration of many distance indicators and age estimations. The prospects opened by Gaia, the next ESA cornerstone, planned for launch in June 2013 (Perryman et al., Astron. Astrophys. 369, 339, 2001), are still much more dramatic: a billion objects with systematic and quasi simultaneous astrometric, spectrophotometric and spectroscopic observations, about 150 million stars with expected distances to better than 10%, all over the Galaxy. All stellar distance indicators, in very large numbers, will be directly measured, providing a direct calibration of their luminosity and making possible detailed studies of the impacts of various effects linked to chemical element abundances, age or cluster membership. With the help of simulations of the data expected from Gaia, obtained from the mission simulator developed by DPAC, we will illustrate what Gaia can provide with some selected examples.Comment: 16 pages, 16 figures, Conference "The Fundamental Cosmic Distance scale: State of the Art and the Gaia perspective, 3-6 May 2011, INAF, Osservatorio Astronomico di Capodimonte, Naples. Accepted for publication in Astrophysics & Space Scienc

Oncogenic Signaling Pathways in The Cancer Genome Atlas

Genetic alterations in signaling pathways that control cell-cycle progression, apoptosis, and cell growth are common hallmarks of cancer, but the extent, mechanisms, and co-occurrence of alterations in these pathways differ between individual tumors and tumor types. Using mutations, copy-number changes, mRNA expression, gene fusions and DNA methylation in 9,125 tumors profiled by The Cancer Genome Atlas (TCGA), we analyzed the mechanisms and patterns of somatic alterations in ten canonical pathways: cell cycle, Hippo, Myc, Notch, Nrf2, PI-3-Kinase/Akt, RTK-RAS, TGFb signaling, p53 and beta-catenin/Wnt. We charted the detailed landscape of pathway alterations in 33 cancer types, stratified into 64 subtypes, and identified patterns of co-occurrence and mutual exclusivity. Eighty-nine percent of tumors had at least one driver alteration in these one alteration potentially targetable by currently available drugs. Thirty percent of tumors had multiple targetable alterations, indicating opportunities for combination therapy

Drivers of Investment in Commercial Real Estate Sustainability: 2006–2018

We investigate the factors (“drivers”) that motivated investment in energy efficiency in commercial real estate office buildings over the 2006–2011 and 2012–2017 period, and looking forward from 2018 in the context of growing concern over carbon emissions around the world. These insights were collected from large Canadian asset managers through interviews conducted in 2017 and 2018. Key findings were that (1) organizations noted an increasing number of factors driving investment decisions over the three periods; (2) cost drivers (payback period and anticipated financial returns) were the top two drivers in 2006–2017; (3) public relations factors became significantly more important looking forward, with brand (reputational impact) as the top-ranked driver and tenant attraction tied for third place; and (4) mitigation against risks such as resilience and anticipated compliance consistently increased in importance. This study contributes to a comprehensive understanding of past, present, and near-future sustainable real estate investment priorities, changing owner behaviors, and the perceived business case for building energy efficiency investments

Holocene isostasy and relative sea-level changes on the east coast of England.

Analysis of sea-level data from the east coast of England identifies local-scale and regional scale factors to explain spatial and temporal variations in the altitude of Holocene sea-level index points. The isostatic effect of the glacial rebound process, including both the ice (glacio-isostatic) and water (hydro-isostatic) load contributions, explains regionalscale differences between eight areas: c. 20 m range at 8 cal. ka BP and by 4 cal. ka BP relative sea-level in Northumberland was above present, whereas in areas to the south relative sea level has been below present throughout the Holocene. Estimates for pre-industrial relative sea-level change range from 1.04 ± 0.12 mm a−1 in the Fenland to −1.30 ± 0.68 mm a−1 (i.e. sea-level fall) in north Northumberland, although this may overestimate the current rate of sea-level fall. Isostatic effects will produce similar relative differences in rates of sea-level change through the twenty-first century. The data agree closely with the patterns predicted by glacio- and hydro-isostatic models, but small systematic differences along the east coast await testing against new ice models. Local scale processes identified include differential isostatic effects within the Humber Estuary and the Fenland, tide range changes during the Holocene, and the effects of sediment consolidation. These processes help explain the variation in altitude between sea-level reconstructions derived from index points taken from basal peats and those from peats intercalated within thick sequences of Holocene sediments