Circuit provides accurate four-quadrant multiplication

Solid state circuit provides four-quadrant multiplication at frequencies ranging from dc to 100 cps using pulse-width and -height multiplication techniques. The circuit consumes little power and has an accuracy of approximately one percent

“Becoming Ioway: Using Auto-Ethnography to Understand the Fourteen Ioways’ Journey of Colonization, Spirituality and Traditions Through Tribal Dance Exhibitions

This thesis analyzes the colonization and traditional spiritual practices of the Ioway people to show that their traditions have survived the effects of colonization also known as white settlers. I focus on issues of cultural traditional exhibition dance and that complicates the question of the nation-state’s exclusively trying to dissemble the Native Ioway Tribe of Kansas and Nebraska of colonization and the effects on the Ioway people past and present. I use personal experience of being a tribal member to discuss how the tribes’ oral history allows for the preservation of Ioway cultural identity and religious traditions

Collisions of electrons and ions with hydrogen atoms Final report, 8 May 1967 - 7 May 1968

Excitation of hydrogen atoms under impact of ions and electron

Réflexion sur la transmission narrative du roman historique suivi de l’Épopée d’un Varègue

Ce mémoire en recherche-création traite du roman historique et de la transmission du savoir historique. La partie théorique vise à clarifier ce qu’est ce genre romanesque, en étudiant la différence entre celui-ci et le travail de l’historien, et à observer le mode de transmission des connaissances historiques de ce type de récit fictionnel à son lecteur. La recherche vise à analyser comment ce genre transmet les informations historiques à son lecteur, sans toutefois bénéficier de la promesse de « vérité » du récit de l’historien. Il est avancé que le récit peut suggérer la vérité plutôt que de l’affirmer et que le roman historique doit être écrit en prenant compte des connaissances supposées de son lecteur. Partant de ce postulat, on questionne, avec l’essai Lector in Fabula d’Umberto Eco, la possibilité de planifier deux niveaux de lecture au sein du récit, un visant à transmettre un récit fictionnel sur un événement historique à un lecteur dont les connaissances du sujet sont restreintes et l’autre pour un lecteur qui maitrise davantage le sujet. La notion de coopération entre le texte et le lecteur permet d’approfondir les stratégies d’écritures rendant possible la transmission du sujet historique par l’intermédiaire de la suggestion (López). Ces stratégies nécessitent la création d’un Lecteur Modèle. Un récit, incomplet sans l’aide de son lecteur, est écrit de façon à guider ce dernier. Pour ce faire, l’auteur pense à un Lecteur Modèle (Eco), muni de certaines compétences encyclopédiques, qui servira d’outil de réflexion pour mettre sur pied les stratégies requises pour orienter son lecteur. La réflexion sur le lecteur permet de poser que seule la volonté du lecteur de lire le texte comme un récit historique permet au roman de l’être et que le rôle de l’auteur est de penser à une façon d’orienter la lecture en ce sens. Cette réflexion est suivie du court roman L’Épopée d’un Varègue, qui présente les aventures d’un Suédois qui devient mercenaire au sein de l’Empire byzantin, durant le XIe siècle. Sa structure s’inspire des récits de Snorri, historien et politicien islandais du XIIIe siècle et sa narration se déploie en fonction de deux lecteurs modèles : celui qui ignore ces événements historiques racontés et celui qui, au contraire, connait le sujet. L’étude de la transmission du savoir historique est mise à contribution pour guider ces deux possibles lecteurs

Copal Bone Cement Is More Effective in Preventing Biofilm Formation than Palacos R-G

Bone cements loaded with combinations of antibiotics are assumed more effective in preventing infection than bone cements with gentamicin as a single drug. Moreover, loading with an additional antibiotic may increase interconnectivity between antibiotic particles to enhance release. We hypothesize addition of clindamycin to a gentamicin-loaded cement yields higher antibiotic release and causes larger inhibition zones against clinical isolates grown on agar and stronger biofilm inhibition. Antibiotic release after 672 hours from Copal bone cement was more extensive (65% of the clindamycin and 41% of the gentamicin incorporated) than from Palacos R-G (4% of the gentamicin incorporated). The higher antibiotic release from Copal resulted in a stronger and more prolonged inhibition of bacterial growth on agar. Bacterial colony counting and confocal laser scanning microscopy of biofilms grown on the bone cements suggest antibiotic release reduced bacterial viability, most notably close to the cement surface. The gentamicin-sensitive Staphylococcus aureus formed gentamicin-resistant small colony variants on Palacos R-G and therefore Copal more effectively decreased biofilm formation than Palacos R-G

Four parameter pulse height analyzer

Circuit design modification of converter and readout system by addition of charge amplifiers at inputs and by addition of fourth D channel- four-parameter pulse height analyze

The impact of video technology on learning: A cooking skills experiment

This study examines the role of video technology in the development of cooking skills. The study explored the views of 141 female participants on whether video technology can promote confidence in learning new cooking skills to assist in meal preparation. Prior to each focus group participants took part in a cooking experiment to assess the most effective method of learning for low-skilled cooks across four experimental conditions (recipe card only; recipe card plus video demonstration; recipe card plus video demonstration conducted in segmented stages; and recipe card plus video demonstration whereby participants freely accessed video demonstrations as and when needed). Focus group findings revealed that video technology was perceived to assist learning in the cooking process in the following ways: (1) improved comprehension of the cooking process; (2) real-time reassurance in the cooking process; (3) assisting the acquisition of new cooking skills; and (4) enhancing the enjoyment of the cooking process. These findings display the potential for video technology to promote motivation and confidence as well as enhancing cooking skills among low-skilled individuals wishing to cook from scratch using fresh ingredients

A qualitative study of community pharmacists' opinions on the provision of osteoporosis disease state management services in Malaysia

Background: Osteoporosis has significant impact on healthcare costs and quality of life. Amongst the models for collaborative disease state management services published internationally, there is sparse evidence regarding the role of community pharmacists in the provision of osteoporosis care. Hence, the aim of our study was to explore community pharmacists' opinions (including the barriers and facilitators) and scope of osteoporosis disease state management services by community pharmacists in Malaysia, informing a vision for developing these services. Methods: Semi-structured individual interviews and focus groups discussions were conducted with community pharmacists from October 2013 to July 2014. Three trained researchers interviewed the participants. Interviews were recorded and transcribed verbatim. Data were analyzed thematically using an interpretative description approach. Results: Nineteen community pharmacists with 1-23 years of experience were recruited (in depth interviews: n = 9; focus group discussions: n = 10). These participants reflected on their experience with osteoporosis-related enquiries, which included medication counseling, bone density screening and referral of at-risk patients. Key barriers were the lack of numerous factors: public awareness of osteoporosis, accurate osteoporosis screening tools for community pharmacists, pharmacists' knowledge on osteoporosis disease and medications, time to counsel patients about bone health, collaboration between pharmacists and doctors, and support from the government and professional body. The pharmacists wanted more continuing education on osteoporosis, osteoporosis awareness campaigns, a simple, unbiased osteoporosis education material, and inter-professional collaboration practices with doctors, and pharmacists' reimbursement for osteoporosis care. Conclusions: The involvement of community pharmacists in the provision of osteoporosis disease state management was minimal. Only ad-hoc counseling on osteoporosis prevention was performed by community pharmacists. Development and trial of collaborative osteoporosis disease state management services in community pharmacy could be facilitated by training, support and remuneration

Telomere uncapping by the G-quadruplex ligand RHPS4 inhibits clonogenic tumour cell growth in vitro and in vivo consistent with a cancer stem cell targeting mechanism

The pentacyclic acridinium methosulfate salt RHPS4 induces the 3′single-stranded guanine-rich telomeric overhang to fold into a G-quadruplex structure. Stabilisation of the latter is incompatible with an attachment of telomerase to the telomere and thus G-quadruplex ligands can effectively inhibit both the catalytic and capping functions of telomerase. In this study, we examined mechanisms underlying telomere uncapping by RHPS4 in uterus carcinoma cells (UXF1138L) with short telomeres and compared the susceptibility of bulk and clonogenic cancer cells to the G-quadruplex ligand. We show that treatment of UXF1138L cells with RHPS4 leads to the displacement of the telomerase catalytic subunit (hTERT) from the nucleus, induction of telomere-initiated DNA-damage signalling and chromosome fusions. We further report that RHPS4 is more potent against cancer cells that grow as colonies in soft agar than cells growing as monolayers. Human cord blood and HEK293T embryonic kidney cell colony forming units, however, were more resistant to RHPS4. RHPS4-treated UXF1138L xenografts had a decreased clonogenicity, showed loss of nuclear hTERT expression and an induction of mitotic abnormalities compared with controls. Although single-agent RHPS4 had limited in vivo efficacy, a combination of RHPS4 with the mitotic spindle poison Taxol caused tumour remissions and further enhancement of telomere dysfunction