Carrying Asymptomatic Malaria In Ouéllé Locality, And Surrounding Villages, In Southeastern Gabon: An Epidemiological Analysis, In Rural Central Africa

Background: Malaria remains a major public health problem in sub-Saharan Africa, and particularly in Gabon. In an epidemiological analysis in a rural area, the present study assessed asymptomatic malaria carriage in Ouéllé, and surrounding villages, in South-eastern Gabon: an epidemiological analysis, in a rural area of central Africa. Patients and method: This prospective, cross-sectional study was conducted from June 26 to 28, 2023. The sociodemographic characteristics of the participants were obtained. A small portion of blood collected by finger prick from each participant was used for qualitative detection of malaria-causing Plasmodium infection, using a Malaria Test MeriScreenTM Pf/PAN Ag lateral flow immunochromatographic assay. Results of analysis by R software version 4.0.3, were considered significant at p≤0.05.Results: Of the 321 people registered for the present study, 97  (30.22%) (95% CI: 0.25 - 0.36) (n=97), tested positive for malaria, compared with 224 (69.78%) ((95% CI: 0.64 - 0.75) (n=224). While a univariate analysis of the prevalence of malaria carriage according to gender showed no statistically significant association between the variables p=0.56, a univariate analysis of the prevalence of malaria carriage according to age group indicated that only participants aged between 28 and 57 (OR =0.17; 95% CI: [0.04 - 0.73] p=0. 007*), and according to each locality, the analysis showed that participants from Mvengué (OR =0.17; CI 95% : [0.04 - 0.73] p=0.007*), Djoutou (OR =0.17; CI 95% : [0.04 - 0.73] p=0. 007*), and Mouyabi (OR =0.17; 95% CI: [0.04 - 0.73] p=0.007*), were statistically susceptible to malaria were significantly associated with malaria carriage in the present study.Conclusion: These results, which indicate the persistence of asymptomatic malaria in Ouéllé and surrounding villages, call on Gabon's health authorities to redouble their efforts to combat malaria throughout the country

Seroprevalence Of Syphilis Among Pregnant Women At The Omar Bongo Ondimba Regional Hospital In Makokou, North-East Of Gabon

ABSTRACTSyphilis is a major public health problem worldwide. Therefore, the present study was conducted to determine the seroprevalence and risk factors associated with this infection among pregnant women. These women were received for a prenatal consultation in 2022 at the laboratory of the Omar Bongo Ondimba Regional Hospital of Makokou (OBORHM), Northeast of Gabon.Patients and Methods: Conducted from April 11 to June 11, 2022, this retrospective, cross-sectional study was based on registers containing sociodemographic information, obstetrical data, and results of examinations for the detection of Treponema pallidum in the pregnant women in the study. Data were analyzed using R software and results were considered significant at a p value ≤ 0.05.Results: A total of 215 records were collected. Of these, 5 were positive for syphilis, indicating an overall prevalence of 2.33% (95% CI: [0.01- 0.53]). Univariate analysis of syphilis prevalence by sociodemographic and obstetric characteristics showed that being between 31 and 40 years of age (Odds Ratio = 7.01; 95% CI [1.13;43.44], p=0.000), and being single (Odds Ratio = 10.0; 95% CI [1.1;91.31] p=0.013), were significantly associated with syphilis prevalence.Conclusion: The results of the present study indicated the existence of syphilis among pregnant women, which can be transmitted to the child in Makokou. They may raise awareness among the population. Emphasis should be placed on systematic screening during prenatal visits of pregnant women.in Gabon.Keywords: Prevalence; Syphilis; Pregnant women; Makokou; Gabo

Caractérisation fonctionnelle de la protéine Rab5A de Plasmodium (rôle dans la régulation de l'endocytose de l'hémoglobine)

PARIS-BIUSJ-Physique recherche (751052113) / SudocSudocFranceF