Sn-PILC: A novel Efficient and Recyclable Catalyst for One-pot Three Component Povarov’s Inverse-electron-demand Hetero Diels-Alder Reaction for a Facile Synthesis of Tetrahydropyranoquinoline Derivatives under Neat Conditions

The Povarov’s inverse-electron-demand hetero Diels–Alder one-pot three components reaction of aromatic aldehyde, aromatic amine with DHF has been developed using Sn-PILC as a catalyst under a neat condition which may helpful to society to get pharmacologically more active compounds. In the present study a novel series of tetrahydroquinoline 4(a-f) were synthesized and characterized by IR, 1HNMR, 13CNMR, Mass spectral analysis and elemental analysis. The synthetic details and characterization results are discussed. DOI: http://dx.doi.org/10.17807/orbital.v8i3.80

Biosynthesis Of Silver Nanoparticle Using Aqueous Extract Of Hibiscus Rosasinensis Leaves

The present study is for the green formation of silver nanoparticles by Hibiscus rosasinensis  leaves extract. After successful formation of silver nanoparticles, Confirmation of Ag nanoparticles has carried out by using various characterizations techniques viz. structural by FT-IR, X-Ray Diffraction (XRD), morphological by Scanning Electron Microscopy (SEM), Atomic Force Microscopy (AFM) and elemental by Energy Dispersive X-ray Spectroscopy (EDX). The silver nanoparticles are also characterized for antibacterial activity. Staphylococi aures, Strepotococci pyogens, Salmonella typhy

ANTIOXIDANT-VITAMIN C: LUNG FUNCTION; LUNG CANCER

ABSTRACTNon-enzymatic vitamin C (ascorbic acid) plays an important role in the medicinal field and acts as antioxidants use in fruits and vegetable such aslemon, orange, grapes, carrots, tomatoes, grapefruit, beans, broccoli, and mangos. It helps to prevent and stop of various diseases such as lung cancer,asthma, and wheezing and finding an antibronchospastic effect. Other factors such as diet have also been implicated in the development of lungcancer. Despite the extensive research conducted in this area, the relationship between diet and lung cancer is still not clear. Diets high in fat andlow in vegetables and fruits may increase the risk of lung cancer and other fact eating of tobacco and smoking of cigarette. Lung tissue damage dueto high levels of free radicals in cigarette smoke causes direct (tissue oxidation) and indirect (release of oxidizing agents and enzymes). Vitamin C isnecessary for phagocytosis. It plays a significant role in daily life, dietary system like eating food, vegetable and smoking of cigarette. It helps to preventor stop the damage the lung tissue/or cause lung cancer. The present review studied that application of vitamin C act as antioxidant in lung cancer likediseases such as lung-cancer and role in lung function.Keywords: Review, Non-enzymatic antioxidant (vitamin C), Lung function, Lung diseases

ANALYTICAL METHOD DEVELOPMENT AND VALIDATION FOR KNOWN AND UNKNOWN IMPURITIES PROFILING FOR CARVEDILOL PHARMACEUTICAL DOSAGE FORM (TABLETS)

Objective: The aim of the research work to develop a simple, sensitive, rugged, robust and specific novel gradient stability indicating reverse phase HPLC method for quantitative determination of known and unknown impurities profiling of Carvedilol pharmaceutical dosage forms (Tablets). Methods: Chromatographic separation has been achieved on an Inertsil ODS 3V column (150 mm x 4.6 mm, 5μm) with mobile phase consisting Mobile phase-A (Water, Acetonitrile and Trifluroacetic acid in the ratio of 80:20:0.1 v/v/v respectively and pH adjusted to 2.0 with dilute potassium hydroxide solution) and Mobile phase-B (Water and acetonitrile in the ratio of 100:900 v/v respectively) delivered at flow rate of 1.0 ml min-1 and the detection wavelength 240 nm. The column compartment temperature maintained at 40 °C. Results: Resolution between Carvedilol and its impurities has been achieved greater than 1.5. The developed method was validated as per ICH guidelines. Analytical method found Precise, Linear, accurate, specific, rugged and robust. Conclusion: Developed and validated novel analytical method can be used to for impurity profile analysis of Carvedilol Pharmaceutical dosage form (Tablets)

GAS CHROMATOGRAPHY - MASS SPECTROMETRY ANALYSIS, INDUCTIVELY COUPLED PLASMA MASS SPECTROMETRY INVESTIGATION, AND ANTIMICROBIAL SCREENING OF CAESALPINIA BONDUCELLA (L.) ROXB SEED KERNEL

Objective: The objective of this study was to determine heavy metals using inductively coupled plasma mass spectrometry (ICP-MS) and phytochemical constituents of methanol extract of Caesalpinia bonducella seed kernel using gas chromatography - mass spectrometry (GC-MS). Methods: In GC-MS investigation, 95% methanol extract of C. bonducella seed kernel was performed on JEOL GC MATE ΙΙ, column HP 5 MS, and Quadruple, double-focusing mass analyzer. Determination of heavy metals from C. bonducella powder was performed using Thermo scientific I CAP Q instrument, for plant powder digestion Anton Paar Microwave model: Multiwave 300 was used. Antimicrobial activity was evaluated using microdilutions broth method. Results: GC-MS analysis of methanol extract of C. bonducella seed kernel has shown 11 different phytoconstituents. ICP-MS analysis has shown the concentration of ten heavy metals in C. bonducella seed kernel as follows: Cr 1.5 ppm, Fe 72.72 ppm, Co 0.33 ppm, Ni 0.03 ppm, Cu 10.73 ppm, Zn 18.44 ppm, As 0.03 ppm, Cd 0.02 ppm, and Pb 0.58 ppm. Conclusion: Result showed that the plant is safe to use from toxic heavy metals such as As, Cd, and Pb. It is suitable to check frequently the heavy metal content in the plant used in traditional medicines before given to patients

Evaluation of Adsorption Capacity of Low Cost Adsorbent for the Removal of Congo Red Dye from Aqueous Solution

Vigna unguiculata seed husk powder has been investigated as low cost adsorbent for the removal of hazardous chemicals like Congo Red (CR) dye from aqueous solution. Various parameters such as effect of contact time, initial CR dye concentration, adsorbent dose, effect of pH, zero-point pH were studied. Batch adsorption technique was employed to optimize the process parameter. The result indicated that, the percentage adsorption of Congo Red increased with increase in contact time, dose of adsorbent and initial concentration of Congo Red and decreased with addition of salt. The adsorption of Congo Red was 78% at the optimum pH of 6. Adsorption equilibrium was found to be reached in 24 h for 5 to 25 g/50 mL Congo red concentrations. The Langmuir and Freundlich isotherm models were found to provide an excellent fitting of the adsorption data.  The adsorption of CR follows Second order rate kinetics. Thermodynamic parameter (δGo) showed that it was an exothermic process. This adsorbent was found to be effective and economically attractive. DOI: http://dx.doi.org/10.17807/orbital.v8i5.83

Adsorption of copper metal ion from aqueous solution by using low cost materials

In this study the matki (Vigna aconitifolia) seed husk was tested for removal of Cu metal ion from solution. Batch adsorption techniques were administered to measure the adsorption characteristics of the matki seed husk for Cu (II) metal ion removal from aqueous solutions. The adsorption isotherms, thermodynamic parameters, kinetics, effect of pH were examined. The results show that the utmost adsorption capacity of matki seed husk was approximately 80.39 % Cu (II) at temperature 305 K and at the initial Cu (II) metal ion concentration of 100 mg/L and at 5.1 pH. Adsorption isotherm data might be well fitted by Frendlich isotherm equation. Thermodynamic studies confirmed that the method was spontaneous and endothermic. The adsorption amounts of Cu (II) metal ion tend to extend with the rise in of pH. The relatively low cost and high capability of the matki seed husk make it potentially attractive adsorbent for the removal of Cu (II) metal ions from waste wate

High Performance Liquid Chromatography-Size Exclusion Chromatography (Hplc-Sec) As an Efficient Tool for The Quantification of Polymers

Poly (lactide-co-glycolide acid) ( PLGA) is an extraordinary well-described polymer and has excellent pharmaceutical properties like high biocompatibility and good biodegradability. Hence, it is one of the most used materials for drug delivery and biomedical systems, also being present in several US Food and Drug Administration approved carrier systems and therapeutic devices. For both applications, the quantification of polymer is important. During the development of the production process, parameters like yield or loading efficacy are essential to be determined. Although PLGA is a well-defined biomaterial, it still lacks a sensitive and convenient quantification approach for PLGA-based systems. Thus, we present a new method for fast and precise quantification of PLGA by HPLC-SEC. The method includes a shorter run time of 20 minutes with a size exclusion column of 300mm x 8.0mm diameter, tetrahydrofuran as mobile phase and diluent, the detection was carried out using the refractive index detector. The developed method has a detection limit of 0.1 ppm, enabling the quantification of low amounts of PLGA. Compared to existing approaches, like gravimetric or nuclear magnetic resonance measurements, which are tedious or expensive, the developed method is fast, ideal for routine screening and it is selective since no interference. The developed method is validated in terms of selectivity, precision, linearity, accuracy and solution stability. Due to the high sensitivity and rapidity of the method, it is suitable for both, laboratory and industrial use  &nbsp

Potentiometric study of atenolol as hypertension drug with Co(II), Ni(II), Cu(II) and Zn(II) transition metal ions in aqueous solution

AbstractBinary and ternary complexes of Co(II), Ni(II), Cu(II) and Zn(II) with atenolol as hypertension drug and glycine have been determined pH metrically at room temperature and 0.01 M ionic strength (NaClO4) in aqueous solution. The formation of various possible species has been evaluated by computer program and discussed in terms of various relative stability parameters

Adsorption Studies of Crystal Violet From Aqueous Solution Using Low Cost Material: Equilibrium and Kinetics Studies

Crystal violet (CV), one of the toxic dyes which are extensively used for dyestuffs, textile, paper and plastics industries. CV does not easily biodegrades in aqueous medium and show harmful effect on aquatic as well as human life. In the present work adsorption studies of CV onto husk powder of Red gram crop (Cajanuscajan) seed was examined in aqueous solution at 27.8ºC. The effects of initial concentration, adsorbent dose, temperature, and contact time etc were determined. Highest 81.49% adsorption efficiency recorded was for 50 mg/L solution concentration onto 2.5g of husk powder of Red gram crop seed. The applicability of Langmuir and Freundlich isotherm model was investigated, and the Langmuir adsorption isotherm model exhibited the best fit than Freundlich isotherm model with the experimental data. The adsorption follows pseudo-second-order kinetics