Long-term Survival After Endovascular and Open Repair of Ruptured Abdominal Aortic Aneurysms

Pla general interior de l'estació de Roquetes Andana central de 8m. d'ample, 100m de llargada i a 50m profunditat, amb bancs de pedra de color blanc en el centre

Heterotic domain wall solutions and SU(3) structure manifolds

We examine compactifications of heterotic string theory on manifolds with SU(3) structure. In particular, we study N = 1/2 domain wall solutions which correspond to the perturbative vacua of the 4D, N =1 supersymmetric theories associated to these compactifications. We extend work which has appeared previously in the literature in two important regards. Firstly, we include two additional fluxes which have been, heretofore, omitted in the general analysis of this situation. This allows for solutions with more general torsion classes than have previously been found. Secondly, we provide explicit solutions for the fluxes as a function of the torsion classes. These solutions are particularly useful in deciding whether equations such as the Bianchi identities can be solved, in addition to the Killing spinor equations themselves. Our work can be used to straightforwardly decide whether any given SU(3) structure on a six-dimensional manifold is associated with a solution to heterotic string theory. To illustrate how to use these results, we discuss a number of examples taken from the literature.Comment: 34 pages, minor corrections in second versio

Pelvic trauma : WSES classification and guidelines

Complex pelvic injuries are among the most dangerous and deadly trauma related lesions. Different classification systems exist, some are based on the mechanism of injury, some on anatomic patterns and some are focusing on the resulting instability requiring operative fixation. The optimal treatment strategy, however, should keep into consideration the hemodynamic status, the anatomic impairment of pelvic ring function and the associated injuries. The management of pelvic trauma patients aims definitively to restore the homeostasis and the normal physiopathology associated to the mechanical stability of the pelvic ring. Thus the management of pelvic trauma must be multidisciplinary and should be ultimately based on the physiology of the patient and the anatomy of the injury. This paper presents the World Society of Emergency Surgery (WSES) classification of pelvic trauma and the management Guidelines.Peer reviewe

Abstracts from the 8th International Conference on cGMP Generators, Effectors and Therapeutic Implications

This work was supported by a restricted research grant of Bayer AG

Genome-wide identification and phenotypic characterization of seizure-associated copy number variations in 741,075 individuals

Copy number variants (CNV) are established risk factors for neurodevelopmental disorders with seizures or epilepsy. With the hypothesis that seizure disorders share genetic risk factors, we pooled CNV data from 10,590 individuals with seizure disorders, 16,109 individuals with clinically validated epilepsy, and 492,324 population controls and identified 25 genome-wide significant loci, 22 of which are novel for seizure disorders, such as deletions at 1p36.33, 1q44, 2p21-p16.3, 3q29, 8p23.3-p23.2, 9p24.3, 10q26.3, 15q11.2, 15q12-q13.1, 16p12.2, 17q21.31, duplications at 2q13, 9q34.3, 16p13.3, 17q12, 19p13.3, 20q13.33, and reciprocal CNVs at 16p11.2, and 22q11.21. Using genetic data from additional 248,751 individuals with 23 neuropsychiatric phenotypes, we explored the pleiotropy of these 25 loci. Finally, in a subset of individuals with epilepsy and detailed clinical data available, we performed phenome-wide association analyses between individual CNVs and clinical annotations categorized through the Human Phenotype Ontology (HPO). For six CNVs, we identified 19 significant associations with specific HPO terms and generated, for all CNVs, phenotype signatures across 17 clinical categories relevant for epileptologists. This is the most comprehensive investigation of CNVs in epilepsy and related seizure disorders, with potential implications for clinical practice

Retrospective evaluation of whole exome and genome mutation calls in 746 cancer samples

Funder: NCI U24CA211006Abstract: The Cancer Genome Atlas (TCGA) and International Cancer Genome Consortium (ICGC) curated consensus somatic mutation calls using whole exome sequencing (WES) and whole genome sequencing (WGS), respectively. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, which aggregated whole genome sequencing data from 2,658 cancers across 38 tumour types, we compare WES and WGS side-by-side from 746 TCGA samples, finding that ~80% of mutations overlap in covered exonic regions. We estimate that low variant allele fraction (VAF < 15%) and clonal heterogeneity contribute up to 68% of private WGS mutations and 71% of private WES mutations. We observe that ~30% of private WGS mutations trace to mutations identified by a single variant caller in WES consensus efforts. WGS captures both ~50% more variation in exonic regions and un-observed mutations in loci with variable GC-content. Together, our analysis highlights technological divergences between two reproducible somatic variant detection efforts

Gefäß(endo)protheseninfektionen: Erfahrungen und Lehren aus 8 Jahren prospektiver Begleitung der VASGRA-Kohorte am Universitätsspital Zürich

Gefäß(endo)protheseninfektionen (GEPI) nach offener Chirurgie oder nach interventioneller Behandlung sind gefürchtete Komplikationen mit weitreichenden Konsequenzen für die betroffenen Patienten. Die Morbiditäts- und Mortalitätsraten des heute immer noch weitgehend gültigen Goldstandards, nämlich die radikale Prothesenentfernung mit in-situ oder extraanatomischer Rekonstruktion, teilweise kombiniert mit plastisch-chirurgischer Deckung, sind generell hoch. 2013 initiierten wir am Universitätsspital Zürich (USZ) deshalb die prospektive Vascular-Graft-(VASGRA)-Kohortenstudie mit dem Ziel, generell vorhandene Unsicherheiten und Unklarheiten bezüglich GEPI zu erforschen und einen allgemeingültigen Managementpfad für GEPI Szilagyi Grad 3 bzw. Samson Grad 3–5 zu entwickeln. Der neue Ansatz bestand darin, extra- und intrakavitäre GEPI mit einem möglichst minimal-invasiven, die Prothese erhaltenden oder teilerhaltenden Konzept unter lokaler NPWT multidisziplinär zu behandeln und zu erforschen. Zum gegenwärtigen Zeitpunkt haben wir umfassende Informationen zu 180 prospektiven Patienten mit GEPI in der Datenbank. Die Indexoperationen bei diesen Patienten mit nachgewiesenem GEPI waren Operationen der thorakalen Aorta (55), Operationen der abdominalen Aorta und/oder Iliakalarterien (92) und infrainguinale Gefäßoperationen (33). Die zensurierte 2‑Jahresmortalität der intrakavitären GEPI beträgt 25 %, diejenige der extrakavitären GEPI ist, nicht signifikant, leicht darunter. Die durch einen GEPI direkt bedingte Langzeit-Mortalität in der VASGRA-Kohortenstudie beträgt 8 %. Zur niedrigen Kurz- und Langzeitmortalität beigetragen haben unserer Ansicht nach das von Beginn weg gelebte multidisziplinäre Gesamtkonzept und neu gewonnene Erkenntnisse der Bildgebung und mikrobiologischen Diagnostik