32 research outputs found
Die Transformation des Alterssicherungssystems: Von der Einheitsrente zum gegliederten einkommensbezogenen System
Phylogenetic analyses of symbiotic genes and characterization of functional traits of Mesorhizobium
Strategien zur Reduzierung des Muellaufkommens Recycling aus der Sicht des Industrial Designs. Abschlussbericht
SIGLEAvailable from TIB Hannover: F96B129 / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekDEGerman
Dynamic enhancer landscapes in human craniofacial development.
The genetic basis of human facial variation and craniofacial birth defects remains poorly understood. Distant-acting transcriptional enhancers control the fine-tuned spatiotemporal expression of genes during critical stages of craniofacial development. However, a lack of accurate maps of the genomic locations and cell type-resolved activities of craniofacial enhancers prevents their systematic exploration in human genetics studies. Here, we combine histone modification, chromatin accessibility, and gene expression profiling of human craniofacial development with single-cell analyses of the developing mouse face to define the regulatory landscape of facial development at tissue- and single cell-resolution. We provide temporal activity profiles for 14,000 human developmental craniofacial enhancers. We find that 56% of human craniofacial enhancers share chromatin accessibility in the mouse and we provide cell population- and embryonic stage-resolved predictions of their in vivo activity. Taken together, our data provide an expansive resource for genetic and developmental studies of human craniofacial development