Studies on metal chelates

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A literature review on implementation of Lean Manufacturing Techniques

Abstract: In competitive environment lean manufacturing is necessary in every industry. Lean production is a standard manufacturing mode of the 21 st century. Lean manufacturing have various synonyms like lean management, lean production, It is very use full techniques for reduce the flow of non value added time. Lean manufacturing is a philosophy to reduce the time between customer order and products are ready for the delivery by eliminating waste. Waste (muda) is a serious problem in to the industry it is creates a non value added services and poor quality of the product. Waste are seven type occurs in industry 1) transport,2) inventory,3)motion,4) waiting,5) over production,6) over processing,7) defect. It is eliminate with the help of lean manufacturing. It is an integrated system that gives production of goods/services with minimum buffering costs. This paper gives the literature survey on various type of industry to apply the lean manufacturing, like apply in to automobile industry, and pharmaceutical company, cotton seed oil industry, health care hospital. And also refers other 5 papers gives the information about lean manufacturing and discussion. And introducing about lean .what is lean manufacturing, why it is needed, and method of lean manufacturing that reduces waste. And also to introduces about different lean tools

Beyond the Epidermal-Melanin-Unit: The Human Scalp Anagen Hair Bulb Is Home to Multiple Melanocyte Subpopulations of Variable Melanogenic Capacity

The visual appearance of humans is derived significantly from our skin and hair color. While melanin from epidermal melanocytes protects our skin from the damaging effects of ultraviolet radiation, the biological value of pigmentation in the hair follicle, particularly on the scalp, is less clear. In this study, we explore the heterogeneity of pigment cells in the human scalp anagen hair follicle bulb, a site conventionally viewed to be focused solely on pigment production for transfer to the hair shaft. Using c-KIT/CD117 microbeads, we isolated bulbar c-KIT-positive and c-KIT-negative melanocytes. While both subpopulations expressed MITF, only the c-KIT-positive fraction expressed SOX10. We further localized bulbar melanocyte subpopulations (expressing c-KIT, SOX10, MITF, and DCT) that exhibited distinct/variable expression of downstream differentiation-associated melanosome markers (e.g., gp100 and Melan-A). The localization of a second ‘immature’ SOX10 negative melanocyte population, which was c-KIT/MITF double-positive, was identified outside of the melanogenic zone in the most peripheral/proximal matrix. This study describes an approach to purifying human scalp anagen hair bulb melanocytes, allowing us to identify unexpected levels of melanocyte heterogeneity. The function of the more immature melanocytes in this part of the hair follicle remains to be elucidated. Could they be in-transit migratory cells ultimately destined to synthesize melanin, or could they contribute to the hair follicle in non-melanogenic ways

State-of-the-art in fast liquid chromatography-mass spectrometry for bio-analytical applications

There is an increasing need of new bio-analytical methodologies with enough sensitivity, robustness and resolution to cope with the analysis of a large number of analytes in complex matrices in short analysis time. For this purpose, all steps included in any bio-analytical method (sampling, extraction, clean-up, chromatographic analysis and detection) must be taken into account to achieve good and reliable results with cost-effective methodologies. The purpose of this review is to describe the state-of-the-art of the most employed technologies in the period 2009–2012 to achieve fast analysis with liquid chromatography coupled to mass spectrometry (LC–MS) methodologies for bio-analytical applications. Current trends in fast liquid chromatography involve the use of several column technologies and this review will focus on the two most frequently applied: sub-2 μm particle size packed columns to achieve ultra high pressure liquid chromatography (UHPLC) separations and porous-shell particle packed columns to attain high efficiency separations with reduced column back-pressures. Additionally, recent automated sample extraction and clean-up methodologies to reduce sample manipulation, variability and total analysis time in bio-analytical applications such as on-line solid phase extraction coupled to HPLC or UHPLC methods, or the use of other approaches such as molecularly imprinted polymers, restricted access materials, and turbulent flow chromatography will also be addressed. The use of mass spectrometry and high or even ultra-high resolution mass spectrometry to reduce sample manipulation and to solve ion suppression or ion enhancement and matrix effects will also be presented. The advantages and drawbacks of all these methodologies for fast and sensitive analysis of biological samples are going to be discussed by means of relevant applications