Reconstructing the Plain Language Rule of Statutory Construction: How and Why

Reconstructing the Plain Language Rule of Statutory Constructio

Adjunctive rifampicin for Staphylococcus aureus bacteraemia (ARREST): a multicentre, randomised, double-blind, placebo-controlled trial.

BACKGROUND: Staphylococcus aureus bacteraemia is a common cause of severe community-acquired and hospital-acquired infection worldwide. We tested the hypothesis that adjunctive rifampicin would reduce bacteriologically confirmed treatment failure or disease recurrence, or death, by enhancing early S aureus killing, sterilising infected foci and blood faster, and reducing risks of dissemination and metastatic infection. METHODS: In this multicentre, randomised, double-blind, placebo-controlled trial, adults (≥18 years) with S aureus bacteraemia who had received ≤96 h of active antibiotic therapy were recruited from 29 UK hospitals. Patients were randomly assigned (1:1) via a computer-generated sequential randomisation list to receive 2 weeks of adjunctive rifampicin (600 mg or 900 mg per day according to weight, oral or intravenous) versus identical placebo, together with standard antibiotic therapy. Randomisation was stratified by centre. Patients, investigators, and those caring for the patients were masked to group allocation. The primary outcome was time to bacteriologically confirmed treatment failure or disease recurrence, or death (all-cause), from randomisation to 12 weeks, adjudicated by an independent review committee masked to the treatment. Analysis was intention to treat. This trial was registered, number ISRCTN37666216, and is closed to new participants. FINDINGS: Between Dec 10, 2012, and Oct 25, 2016, 758 eligible participants were randomly assigned: 370 to rifampicin and 388 to placebo. 485 (64%) participants had community-acquired S aureus infections, and 132 (17%) had nosocomial S aureus infections. 47 (6%) had meticillin-resistant infections. 301 (40%) participants had an initial deep infection focus. Standard antibiotics were given for 29 (IQR 18-45) days; 619 (82%) participants received flucloxacillin. By week 12, 62 (17%) of participants who received rifampicin versus 71 (18%) who received placebo experienced treatment failure or disease recurrence, or died (absolute risk difference -1·4%, 95% CI -7·0 to 4·3; hazard ratio 0·96, 0·68-1·35, p=0·81). From randomisation to 12 weeks, no evidence of differences in serious (p=0·17) or grade 3-4 (p=0·36) adverse events were observed; however, 63 (17%) participants in the rifampicin group versus 39 (10%) in the placebo group had antibiotic or trial drug-modifying adverse events (p=0·004), and 24 (6%) versus six (2%) had drug interactions (p=0·0005). INTERPRETATION: Adjunctive rifampicin provided no overall benefit over standard antibiotic therapy in adults with S aureus bacteraemia. FUNDING: UK National Institute for Health Research Health Technology Assessment

The Obergefell Marriage Equality Decision, with Its Emphasis on Human Dignity, and a Fundamental Right to Food Security

Today, the welfare rights movement has faltered. However, the Supreme Court’s recent marriage equality decision, with its emphasis on human dignity, lends hope to the notion that the Court should also acknowledge a right to food security. This Article identifies the role human dignity has served in the Court’s constitutional analysis to acknowledge and protect, for example, rights to privacy, to travel, to be heard, to self‐representation, to marry, to speak freely, and to preserve bodily integrity. According to the Court, these rights are all a part of liberty. Arguably, and as FDR said, “[i]f, as our Constitution tells us, our Federal Government was established among other things, to ‘promote general welfare,’ it is our plain duty to provide for that security upon which welfare depends.” This Article briefly examines food insecurity in the United States, showing that approximately 17 million households in this country suffer from food insecurity. This section also identifies the Court’s jurisprudence regarding welfare rights, describing cases from the early 1970s forward that have routinely favored the government. The article’s crux is the five arguments why the Court should acknowledge a constitutional right to food security, discounting those arguments commentators routinely wage against such a right. Scholars have written on human dignity as a constitutional value. This Article stands apart by linking the Court’s treatment of human dignity to a right to food security based largely on the role human dignity has played in Supreme Court jurisprudence, most recently in Obergefell v. Hodges. The Article also debunks the five main arguments commentators level against the Court protecting such a right, and, ideally, sets the stage for renewed efforts by lawyers and commentators to pursue a fundamental right to food security

Learning Design Patterns with Bayesian Grammar Induction

Design patterns have proven useful in many creative fields, providing content creators with archetypal, reusable guidelines to leverage in projects. Creating such patterns, however, is a time-consuming, manual process, typically relegated to a few experts in any given domain. In this paper, we describe an algorithmic method for learning design patterns directly from data using techniques from natural language processing and structured concept learning. Given a set of labeled, hierarchical designs as input, we induce a probabilistic formal grammar over these exemplars. Once learned, this grammar encodes a set of generative rules for the class of designs, which can be sampled to synthesize novel artifacts. We demonstrate the method on geometric models and Web pages, and discuss how the learned patterns can drive new interaction mechanisms for content creators. ACM Classification Keywords H.1.2. [Models and Principles]: User/Machine Systems