Gluon Field Strength Correlation Functions within a Constrained Instanton Model

We suggest a constrained instanton (CI) solution in the physical QCD vacuum which is described by large-scale vacuum field fluctuations. This solution decays exponentially at large distances. It is stable only if the interaction of the instanton with the background vacuum field is small and additional constraints are introduced. The CI solution is explicitly constructed in the ansatz form, and the two-point vacuum correlator of gluon field strengths is calculated in the framework of the effective instanton vacuum model. At small distances the results are qualitatively similar to the single instanton (SI) case, in particular, the form factor $D_{1}$ is small, which is in agreement with the lattice calculations.Comment: 25 pages (RevTex), 7 ps figures; some references added, one figure replace

Multilevel Analysis of Oscillation Motions in Active Regions of the Sun

We present a new method that combines the results of an oscillation study made in optical and radio observations. The optical spectral measurements in photospheric and chromospheric lines of the line-of-sight velocity were carried out at the Sayan Solar Observatory. The radio maps of the Sun were obtained with the Nobeyama Radioheliograph at 1.76 cm. Radio sources associated with the sunspots were analyzed to study the oscillation processes in the chromosphere-corona transition region in the layer with magnetic field B=2000 G. A high level of instability of the oscillations in the optical and radio data was found. We used a wavelet analysis for the spectra. The best similarities of the spectra of oscillations obtained by the two methods were detected in the three-minute oscillations inside the sunspot umbra for the dates when the active regions were situated near the center of the solar disk. A comparison of the wavelet spectra for optical and radio observations showed a time delay of about 50 seconds of the radio results with respect to optical ones. This implies a MHD wave traveling upward inside the umbral magnetic tube of the sunspot. Besides three-minute and five-minute ones, oscillations with longer periods (8 and 15 minutes) were detected in optical and radio records.Comment: 17 pages, 9 figures, accepted to Solar Physics (18 Jan 2011). The final publication is available at http://www.springerlink.co

A36 The TP53 mutations in the Russian patients with de novo DLBCL

BackgroundTP53 dysfunction is implicated in lymphomagenesis and disease progression. Information about the frequency and spectrum of TP53 mutations in the Russian pathients with diffuse large B-cell lymphoma (DLBCL) in the current version of the IARC TP53 Mutation Database R17 is not represented. The goal of this work was to study the frequency, spectrum and functional significance of TP53 mutations in Russian patients with DLBCL.Material and methodsAt the present time the pilot group of 14 patients were included in the study. Diagnosis was assessed according to the criteria of the WHO classification system. Genomic DNA was isolated from formalin-fixed, paraffin embedded tissue blocks. Direct sequence analysis of gene TP53 was performed according to the IARC protocol, 2010 update.ResultsIn two patients were identified single nucleotide substitutions that are not described in the current version of the PubMed database. All of mutations occurred in the DNA-binding domain of p53. The nonsense mutation Arg196Ter was detected in one patient. Previously it was shown that formation of this premature stop codon might activate the nonsense-mediated RNA decay pathway. The second patient had two missense mutations – Leu130Phe and Arg156Cys. The first of them leads to p53 inactivation according to the analysis of the functional importance of amino acid substitutions using service PolyPhen-2.ConclusionWe detected TP53 mutation in 14% cases. The mutational rate in our study is in good agreement with other studies where the frequency of the TP53 mutations in patients with DLBCL ranged mostly from 13% to 23%

How much laser power can propagate through fusion plasma?

Propagation of intense laser beams is crucial for inertial confinement fusion, which requires precise beam control to achieve the compression and heating necessary to ignite the fusion reaction. The National Ignition Facility (NIF), where fusion will be attempted, is now under construction. Control of intense beam propagation may be ruined by laser beam self-focusing. We have identified the maximum laser beam power that can propagate through fusion plasma without significant self-focusing and have found excellent agreement with recent experimental data, and suggest a way to increase that maximum by appropriate choice of plasma composition with implication for NIF designs. Our theory also leads to the prediction of anti-correlation between beam spray and backscatter and suggests the indirect control of backscatter through manipulation of plasma ionization state or acoustic damping.Comment: 15 pages, 4 figures, submitted to Plasma Physics and Controlled Fusio