Optimising the Timing of Health Resort Treatment in Patients with Arterial Hypertension and Increased Meteosensitivity: a Prospective Study

INTRODUCTION. Arterial hypertension (AH) is a socially significant disease. A significant proportion of patients with AH are weather-sensitive, which significantly aggravates the course of the underlying disease. AIM. To develop programs for restoring the functional state and adaptive capabilities of patients with arterial hypertension and increased weather sensitivity in order to optimize the duration of their spa treatment. MATERIALS AND METHODS. An observational prospective clinical comparative study of 129 patients aged 62 [56; 68] years was conducted for 12 days. The patients were divided into 3 groups. All patients received general sodium chloride baths, gas-air carbon dioxide baths, parafango applications, hyperbaric oxygenation, therapeutic exercises, cognitive-behavioral therapy, and continuous hypotensive drug therapy. Additionally, the first group of patients received dosed aerotherapy together with therapeutic exercises, and the second group received paradoxical breathing exercises using the Strelnikova method. Before and after the course of treatment, anthropometry, peripheral hemodynamics, heart rate variability, and the psychophysiological state of the patients were assessed. RESULTS AND DISCUSSION. After completion of treatment, statistically significant differences were obtained in all groups of patients in terms of a decrease in systolic blood pressure (SBP) and an increase in the Well-Being scale scores of the SAN test (according to the Wilcoxon test, p 0.05). In the first group of patients, after treatment, a statistically significant decrease in elevated pulse pressure, heart rate (HR), integral and frequency indices of heart rate variability (RMSSD, SDNN, LW, IN, PARS) was observed (according to the Wilcoxon test, p 0.05). Statistically significant differences were revealed between the first and third groups in the level of reduction of initially elevated systolic (U = 54.0, p = 0.02) and pulse BP (U = 55.5, p = 0.023), HR (U = 56.0, p = 0.037), RMSSD, SDNN, LW, IN, PARS (U = 13.0, p = 0.048; U = 34.2, p = 0.033; U = 13.0, p = 0.048; U = 0.0, p = 0.02; U = 48.0, p = 0.033, respectively), and the Well-Being scale of the SAN questionnaire (U = 50.0, p = 0.043). CONCLUSION. The study has shown the effectiveness of non-drug treatment programme for AH with increased meteosensitivity, including procedures of aerotherapy and exercise therapy, allowing to optimize the terms of health-resort treatment

The International Linear Collider:Report to Snowmass 2021

The International Linear Collider (ILC) is on the table now as a new global energy-frontier accelerator laboratory taking data in the 2030s. The ILC addresses key questions for our current understanding of particle physics. It is based on a proven accelerator technology. Its experiments will challenge the Standard Model of particle physics and will provide a new window to look beyond it. This document brings the story of the ILC up to date, emphasizing its strong physics motivation, its readiness for construction, and the opportunity it presents to the US and the global particle physics community

Natural Therapeutic Resources of the Russian Federation: Updated Legislation and Medical Aspects of their Application

The article outlines the provisions of the modern regulatory framework that regulates the work of health spa (sanatorium) organizations and the use of natural healing resources for therapeutic purposes. The legislative innovations, the main tasks and problems of the development of the spa and resort industry from a medical point of view are described. The historical background of the development of the spa and resort medical industry in the context of natural resources is presented. It describes the development of health resort business in Russia from the emergence of the first sanatorium to the present day

Innovative Methods of the Interdisciplinary Approach to Medical Rehabilitation in Children with Bronchial Asthma

The childhood incidence of bronchial asthma is the most common chronic pathology in children. Due to the influence of many factors,as well as due to the widespread prevalence, the problem is becoming particularly relevant today. In recent years, a frequently usedconcept of medical rehabilitation is the so-called “multidisciplinary approach”, which also consists in the implementation of a personalizedapproach. Aim. To develop a comprehensive targeted program for the medical rehabilitation of children with bronchial asthma, to study the effectivenessof a comprehensive targeted program selected taking into account the individual characteristics of the child. Material and methods. There was developed an individual targeted program of medical rehabilitation was developed, in accordancewith the procedures and standards of medical care, taking into account indications and contraindications, taking into account a multidisciplinaryapproach, and rehabilitation methods, namely, such as: climatotherapy, physiotherapy, speleotherapy, aromatherapy,inhalation therapy, oxygen therapy, hypoxytherapy, mechanotherapy, psychocorrection, massage, physical therapy, phytotherapy.The patients were divided into three groups by randomization, without reference to the treatment method or any other factor. Allthree groups of patients received a basic program of medical rehabilitation, which included magnetotherapy, dry carbon dioxidebaths,speleotherapy and physical therapy. Results. Positive indicators of clinical and laboratory results and subjective data as a resultof rehabilitation were obtained in all patients from all 3 groups. In children with bronchial asthma of mixed genesis, as a result of complextreatment, a significant improvement was noted. These results allow us to speak about the significant effectiveness of individuallyselected targeted medical rehabilitation programs in patients with bronchial asthma. Conclusion. As a result of the analytical work carried out according to the results of the study, it can be concluded that the use of anindividual rehabilitation complex of procedures and therapeutic techniques in children’s patients with bronchial asthma is effective.The implementation of these methods in a complex improves the condition and well-being of patients according to a subjective feeling,and also allows us to reliably speak about the improvement of the condition according to clinical and diagnostic indicators. It ispossible to recommend the introduction of the use of these programs in the medical rehabilitation of this group of patients. Drawingup targeted programs for use in children’s patients with a history of bronchial asthma is an important link in medical rehabilitation,as it allows each patient to conduct an individually selected targeted rehabilitation program in the conditions of the department ofmedical rehabilitation for patients with somatic diseases.</jats:p

Medical Rehabilitation and Health Resort Treatment at the Resort “Sernovodsk-Kavkazsky”

INTRODUCTION. Medical rehabilitation and health resort treatment are important parts of the health care system of the Chechen Republic, which are actively developing with high potential and competitiveness. Studies on the treatment of patients with chronic non-communicable diseases show the effectiveness of natural therapeutic resources and other innovative non-medication methods. AIM. To analyze and identify the most promising for the development of the Resort “Sernovodsk-Kavkazsky” directions of treatment of patients with chronic non-infectious diseases. MATERIALS AND METHODS. Data from information-analytical systems of the sanatorium-resort industry of the Russian Federation and the data of our own research were used for the analysis. RESULTS. The analysis and the main results confirming the effectiveness of treatment of patients with chronic non-infectious diseases with the use of natural healing resources and other innovative non-medication methods realized in the Resort “Sernovodsk-Kavkazsky” are presented. The most promising ways of development of health resort treatment and medical rehabilitation are determined. CONCLUSION. The increasing activity of unfavorable environmental factors, which negatively affect the functional state of the organism and the level of health of the population as a whole, require from the health care system continuous improvement, including in the sanatorium and resort industry

Medical Staff at Sanatorium-Resort Organizations: Working Conditions and Health Risk Factors

Medical staff working conditions are characterized by a range of adverse workplace factors investigated primarily at hospital organizations. However, sanitary audit of working conditions and health risk factors for medical workers in the sanatorium-resort industry is also a task that needs attention. Aim. To analyze the results of the working conditions special assessment and identify the main work-related factors affecting health state of medical staff at sanatorium-resort organizations. Material and methods. Scientific search and analysis of publications on the safety of working conditions and health protection of medical workers. Systematization of research materials, statistical and comparative analysis of the results of working conditions special assessment carried out at branches of the Medical Research Center and data provided in publications. Results. Medical staff are exposed to a wide range of hazards. Work-related factors that do not meet established hygiene standards cause the greatest concern among medical workers. These are microclimate, lighting and working equipment (47.0%, 37.8% and 24.0%, respectively). A number of devices inspected in the physiotherapy room exceeded hygienic standards for alternating electric and magnetic field intensity. Analysis of air pollution in the physiotherapy department working area showed that some of the harmful chemicals exceeded permissible exposure limits. The results of the special assessment of working conditions performed at branches of the Medical Research Center showed that a high percentage of medical workers was exposed to harmful biological factors and high severity of the labor process. Conclusion. Physical and chemical factors are the greatest workplace hazards for healthcare workers at health resorts. However, a special assessment of working conditions showed that the biological factor was the most significant one across all professional groups.</jats:p

Соmplex Medical Rehabilitation for Cancer-related Lower Limbs Lymphedema: a Prospective Comparative Randomized Study of 60 Patients

INTRODUCTION. The management of patients with secondary lymphedema of the lower extremities associated with radical treatment of pelvic cancer (Cancer Related Lymphedema) is extremely problematic due to persistent impairment of the draining function of regional lymph nodes due to intraoperative dissection and subsequent radiation therapy. AIM. To compare the effectiveness of complex medical rehabilitation using the kinesio taping method and innovative non-stretchable compression bandages in patients with secondary lymphedema of the lower extremities associated with radical treatment of pelvic cancer. MATERIAL AND METHODS. The study involved 60 patients with stages I-III Cancer Related Lymphedema (according to the classification of Savchenko T.V., Pokrovsky A.V., 2004) who underwent radical treatment for various forms of pelvic cancer (gynecological cancer in women and prostate cancer in men), randomized into 2 groups (30 people each). A comprehensive rehabilitation was carried out in the main group (n=30), including sequential manual lymphatic drainage, skin care, kinesio taping, therapeutic gymnastics in the gym; Adjustable Non-stretchable Compression Bandages (circaid juxtafit, Germany). Meanwhile, a Complex Decongestive Therapy was performed in the comparison group (n=30), which is considered as the gold standard of conservative treatment of lymphedema of the lower extremities, including manual lymphatic drainage, skin care, Multi-layered limb banding using Inelastic compression Bandages. In order to evaluate the anti-edematous effect the dynamics of the circumferences of the lower extremities, waist circumference and hip circumference, the Ankle Range of Motion were examined using goniometry, bio-impedancemetry. Laser Doppler Flowmetry was used to evaluate microcirculatory parameters. RESULTS AND DISCUSSION. There was a decrease in swelling and thickening of the skin in the thigh, a decrease the external genitalia edema in patients with Cancer Related Lymphedema in both groups after a course of rehabilitation. There was a regression of swelling of the feet and lower legs in patients of both groups (p<0.05) after treatment, which was confirmed by a decrease in the circumferences of the lower limbs. There was an increase in the Ankle Range of Motion (dorsiflexion) from 17.50±1.26° to 19.25±1.52° (p<0.05) in the main group and from 17.90±1.44° to 18.59±1.10° (p<0.05) in the comparison group. According to the bio-impedancemetry data, there was a decrease in the extracellular fluid content both in the main group and the comparison group by 2.64% and 2.83%, (p<0.05) respectively. There was also a comparable decrease in the total fluid content by 2.67% in the main group and 1.90% (p<0.05) in the comparison group. There were a decrease in body weight by 2.49% and 1.52% (p<0.001), a decrease in fat mass by 2.62% and 4.01% (p<0.05) in both groups respectively after the course of treatment. According to the Laser Doppler Flowmetry data, there were an improvement in the indicators of myogenic tone of arterioles and secretory activity of the endothelium, as well as elimination of venular congestion in patients of both groups (p<0.05). CONCLUSION. Regression of edema in Cancer Related Lymphedema can be achieved as a result of the use of manual lymphatic drainage which stimulates the outflow of lymph through lymphatic watersheds into adjacent lymphatic territories with intact regional lymph nodes, which was achieved in both groups. The lymphatic drainage effect of manual lymphatic drainage was supported by the daily compression profile of bandages (Multi-layered Inelastic Bandages and Adjustable Non-stretchable Compression Bandages) in patients of both groups. Our study showed that the use of kinesio tapes leveled the difference in compression of approximately 10-15 mmHg between the bandages used (50 mmHg/~60 mmHg)

Соmplex Medical Rehabilitation for Cancer-related Lower Limbs Lymphedema: a Prospective Comparative Randomized Study of 60 Patients

INTRODUCTION. The management of patients with secondary lymphedema of the lower extremities associated with radical treatment of pelvic cancer (Cancer Related Lymphedema) is extremely problematic due to persistent impairment of the draining function of regional lymph nodes due to intraoperative dissection and subsequent radiation therapy. AIM. To compare the effectiveness of complex medical rehabilitation using the kinesio taping method and innovative non-stretchable compression bandages in patients with secondary lymphedema of the lower extremities associated with radical treatment of pelvic cancer. MATERIAL AND METHODS. The study involved 60 patients with stages I-III Cancer Related Lymphedema (according to the classification of Savchenko T.V., Pokrovsky A.V., 2004) who underwent radical treatment for various forms of pelvic cancer (gynecological cancer in women and prostate cancer in men), randomized into 2 groups (30 people each). A comprehensive rehabilitation was carried out in the main group (n=30), including sequential manual lymphatic drainage, skin care, kinesio taping, therapeutic gymnastics in the gym; Adjustable Non-stretchable Compression Bandages (circaid juxtafit, Germany). Meanwhile, a Complex Decongestive Therapy was performed in the comparison group (n=30), which is considered as the gold standard of conservative treatment of lymphedema of the lower extremities, including manual lymphatic drainage, skin care, Multi-layered limb banding using Inelastic compression Bandages. In order to evaluate the anti-edematous effect the dynamics of the circumferences of the lower extremities, waist circumference and hip circumference, the Ankle Range of Motion were examined using goniometry, bio-impedancemetry. Laser Doppler Flowmetry was used to evaluate microcirculatory parameters. RESULTS AND DISCUSSION. There was a decrease in swelling and thickening of the skin in the thigh, a decrease the external genitalia edema in patients with Cancer Related Lymphedema in both groups after a course of rehabilitation. There was a regression of swelling of the feet and lower legs in patients of both groups (p&lt;0.05) after treatment, which was confirmed by a decrease in the circumferences of the lower limbs. There was an increase in the Ankle Range of Motion (dorsiflexion) from 17.50±1.26° to 19.25±1.52° (p&lt;0.05) in the main group and from 17.90±1.44° to 18.59±1.10° (p&lt;0.05) in the comparison group. According to the bio-impedancemetry data, there was a decrease in the extracellular fluid content both in the main group and the comparison group by 2.64% and 2.83%, (p&lt;0.05) respectively. There was also a comparable decrease in the total fluid content by 2.67% in the main group and 1.90% (p&lt;0.05) in the comparison group. There were a decrease in body weight by 2.49% and 1.52% (p&lt;0.001), a decrease in fat mass by 2.62% and 4.01% (p&lt;0.05) in both groups respectively after the course of treatment. According to the Laser Doppler Flowmetry data, there were an improvement in the indicators of myogenic tone of arterioles and secretory activity of the endothelium, as well as elimination of venular congestion in patients of both groups (p&lt;0.05). CONCLUSION. Regression of edema in Cancer Related Lymphedema can be achieved as a result of the use of manual lymphatic drainage which stimulates the outflow of lymph through lymphatic watersheds into adjacent lymphatic territories with intact regional lymph nodes, which was achieved in both groups. The lymphatic drainage effect of manual lymphatic drainage was supported by the daily compression profile of bandages (Multi-layered Inelastic Bandages and Adjustable Non-stretchable Compression Bandages) in patients of both groups. Our study showed that the use of kinesio tapes leveled the difference in compression of approximately 10-15 mmHg between the bandages used (50 mmHg/~60 mmHg).</jats:p

High Intensity Pulsed Magnetic Field Application in Patients with Chronic Prostatitis Complicated by Erectile Dysfunction: а Randomized Prospective Study

INTRODUCTION. Chronic prostatitis is one of the most common urological nosologies, the third most common diagnosis in men under 50 years old. Existing scientific sources testify to the effectiveness of various physiotherapeutic interventions in patients with infectious-inflammatory diseases of the male reproductive system, complicated by erectile dysfunction. AIM. The aim of the study was the scientific substantiation of high-intensity pulsed magnetic field application in patients with chronic prostatitis complicated by erectile dysfunction. MATERIAL AND METHODS. The study included 60 patients randomized into two groups. The first group (30 people) received high-intensity pulsed magnetic field; the second group (30 people) received drug therapy. RESULTS AND DISCUSSION. It was shown that the high clinical results of high-intensity pulsed magnetic field application were based on the compensation of local blood circulation conditioned by the improvement of the prostate blood flow according to the ultrasound of the prostatic vessels as well as by the elimination of the penile blood supply deficiency due to the improvement of the arterial vessels tone and elimination of venous stasis according to laser doppler flowmetry. CONCLUSION. An innovative method has been developed to treat patients with chronic prostatitis complicated by erectile dysfunction using high-intensity pulsed magnetic field

Review of the Elemental Status in Blood Serum in Patients with Ischemic Stroke

The study of the elemental status in the modern paradigm of medical diagnostics occupies an increasingly large niche due to the possible use of trace elements as possible predictors of cerebrovascular pathologies. Moreover, the great importance of the elemental component in the main enzymatic systems of metabolism allows us to consider them also as a therapeutic target. There are many mechanisms in the pathophysiology of stroke development, each of which, in one way or another, is mediated through the interaction of regulatory proteins with trace elements as cofactors. Therefore, it is necessary to pay close attention to elemental homeostasis in the focus of ischemic pathologies. Aim. Systematization of the known pathogenetic effects of the most metabolic homeostasis important elements on the course of stroke, both contributing factors to earlier rehabilitation and minimal neurological deficit after the ischemic event itself, and factors aggravating the recovery process and leading to serious neurological consequences. This pursues not only a prognostic goal to determine the severity of ischemia or to identify risk groups with certain shifts in elemental constants, but also the therapeutic one — to replace the falling functions of the dropping metabolic agents, as happens with the elements involved in antioxidant systems. It is also necessary to develop a methodology for stopping the excess of nerve cells mediating excitotoxicity with calcium ions, which closes the vicious circle of vascular necrosis with additional destruction of the nervous tissue. Conclusion. The conclusions that we can summarize quite convincingly indicate a significant contribution of the elemental status to the pathogenesis of ischemic stroke. Dysregulation of the elemental component can force the damaging effect of ischemia on brain cells. At the same time, many elements show a surplus during an ischemic event: Li, I, Mn, Zn, As, Se, Pb, Sr, Ni, however, not all of the presented elements negatively affect the course of stroke, since an increase in the level of some metals may be compensatory in nature, and for their further applicability as diagnostic and therapeutic agents, similar analytics are required.</jats:p