The structure of molecular clumps around high-mass young stellar objects

We have used the IRAM 30-m and FCRAO 14-m telescopes to observe the molecular clumps associated with 12 ultracompact (UC) HII regions in the J=6-5, 8-7 and 13-12 rotational transitions of methyl-acetylene (CH3C2H). Under the assumption of LTE and optically thin emission, we have derived temperature estimates ranging from 30 to 56 K. We estimate that the clumps have diameters of 0.2-1.6 pc, H_2 densities of 10^5-10^6 {cm^{-3}}, and masses of 10^2-2 10^4 M_\odot. We compare these values with those obtained by other authors from different molecular tracers and find that the H_2 density and the temperature inside the clumps vary respectively like n_{H_2} ~ R^{-2.6} and T ~ R^{-0.5}, with R distance from the centre. We also find that the virial masses of the clumps are ~3 times less than those derived from the CH3C2H column densities: we show that a plausible explanation is that magnetic fields play an important role to stabilise the clumps, which are on the verge of gravitational collapse. Finally, we show that the CH3C2H line width increases for decreasing distance from the clump centre: this effect is consistent with infall in the inner regions of the clumps. We conclude that the clumps around UC HII regions are likely to be transient (~10^(5) yr) entities, remnants of isothermal spheres currently undergoing gravitational collapse: the high mass accretion rates (~10^{-2} M_\odot yr^{-1}) lead to massive star formation at the centre of such clumps.Comment: 15 pages, 11 figures, A & A in pres

Nestin expression associates with poor prognosis and triple negative phenotype in locally advanced (T4) breast cancer

Nestin, an intermediate filament protein, has traditionally been noted for its importance as a neural stem cell marker. However, in recent years, expression of nestin has shown to be associated with general proliferation of progenitor cell populations within neoplasms. There is no reported study addressing nestin expression in T4 breast cancer patients. Thus, the aim of the present study was to investigate, through immunohistochemistry, the expression and distribution of nestin in T4 breast cancer, in order to determine its association with clinical and pathological parameters as well as with patients' outcome. Nestin was detectable in tumoral cells and in endothelial cells of blood microvessels, and it is significantly expressed in triple-negative and in inflammatory breast cancer (IBC) subgroups of T4 breast tumours. The Kaplan-Meier analysis showed that the presence of nestin in tumoral cells significantly predicted poor prognosis at 5-years survival (P=0.02) and with borderline significance at 10-years of survival (P=0.05) in T4 breast cancer patients. On the basis of these observations, we speculate that nestin expression may characterize tumours with an aggressive clinical behavior, suggesting that the presence of nestin in tumoral cells and vessels may be considered an important factor that leads to a poor prognosis. Further studies are awaited to define the biological role of nestin in the etiology of these subgroups of breast cancers